Publications by authors named "Ci-Sian Wang"
Heat-inactivated Lactobacillus casei strain GKC1 Mitigates osteoporosis development in vivo via enhanced osteogenesis.
Biochem Biophys Res Commun
January 2025
Osteoporosis, a significant bone disease predominantly affecting elderly and postmenopausal women, leads to increased bone fragility and fracture risk, presenting a major public health concern with substantial socioeconomic implications. This study investigated the therapeutic potential of Lactobacillus strains, known for their immunomodulatory properties, in an ovariectomy-induced osteoporosis mouse model. Among three tested strains Lactobacillus casei GKC1, Lactobacillus rhamnosus GKLC1, and Lactobacillus johnsonii GKJ2, GKC1 demonstrated superior efficacy in promoting osteogenesis-related gene expression, including alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP2) and runt-related transcription factor 2 (RUNX2).
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- Obesity is a major global health issue linked to various metabolic and chronic diseases, including gout.
- This study assesses the effects of a supplement called GKM3 on obesity and its related complications in high-fat-diet-induced obese rats.
- Results indicate that GKM3 supplementation reversed weight gain, fat accumulation, and other adverse effects caused by a high-fat diet, suggesting its potential as an antiobesity and uric acid-lowering treatment.