Publications by authors named "Chuying Wang"

Excessive fat accumulation and chronic inflammation are two typical characteristics of obesity. AMP-activated protein kinase (AMPK), a master regulator of energy metabolism, is involved in adipogenesis, lipogenesis, and inflammation modulation in adipose tissue (AT). Thus, effective lipid reduction and anti-inflammation through AMPK regulation play vital roles in treating obesity.

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  • The study investigates how endoplasmic reticulum (ER) stress is related to immune disorders in ischemic stroke (IS), focusing on systemic immune responses.
  • Researchers identified 32 ER stress-related genes and pinpointed three key genes (ATF6, DDIT3, ERP29) that play significant roles in this process using various analysis methods.
  • The findings suggest a strong link between these key genes and macrophage cell ER stress in IS, indicating potential pathways for improving clinical practices in treating stroke patients.
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  • All-inorganic cesium copper halide nanocrystals are gaining interest for their affordability, low toxicity, and impressive light-emitting capabilities.
  • The study focuses on how oleylammonium iodide affects the synthesis of these nanocrystals, allowing for better control over their composition and enhanced photoluminescence quantum yields.
  • The findings highlight that specific nanocrystals can emit white light with high luminous efficiency, making them suitable for future applications in light-emitting technologies.
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Materials with two or more fluorescence features under different excitation sources have great potential in optical applications, but luminous materials with three emission characteristics have been largely undeveloped. Here, we report a novel zero-dimensional (0D) organic-inorganic hybrid ((CH)N)ZrCl perovskite with multiple emissions. The zirconium-based perovskite exhibits a red emission around 620 nm, a green emission at 527 nm, and a blue emission around 500 nm.

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Background: Neuroendocrine neoplasm (NEN) is a group of rare tumors. Among which, gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is the most common group. The World Health Organization (WHO) classified these tumors into three different grades (G1, G2, and G3) based on Ki-67 and mitotic rate, and updated the classification in 2019.

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  • Basal-like breast cancers (BLBCs) are highly aggressive due to the presence of cancer stem cells (CSCs) and their association with epithelial-mesenchymal transition (EMT), which is influenced by the loss of GATA3, a gene that helps maintain luminal cell identity.
  • The study reveals that when Gata3 is deleted in mice, it leads to an increase in Fra1, a protein promoting mesenchymal traits, and a decrease in c-Fos, which helps maintain epithelial characteristics, ultimately initiating tumorigenesis and metastasis.
  • Findings also indicate that GATA3 directly regulates the expression of FRA1 and c-FOS, with low levels of GATA3 being linked to unfavorable profiles in human breast
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Recently, lead halide perovskite nanocrystals (NCs) have attracted extensive attention due to their unique optical properties. However, the toxicity of lead and the instability to moisture obstruct their further commercial development. Herein, a series of lead-free CsMnX (X = Cl, Br, and I) NCs embedded in glasses were synthesized by a high temperature solid-state chemistry method.

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The absorption and photoluminescence (PL) of CsMnBr with Mn(II) in octahedral crystal fields are extremely weak due to a d-d forbidden transition. Herein, we introduce a facile and general synthetic procedure that can prepare undoped and heterometallic doped CsMnBr NCs at room temperature. Importantly, both PL and absorption of CsMnBr NCs were significantly improved after doping a small amount of Pb (4.

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  • - Researchers are focusing on single-component phosphors that emit light in broad bands to improve color quality (CRI) and warmth (CCT) in white-light-emitting diodes (WLEDs) since such materials are currently scarce.
  • - The study introduces a simple solid-state method to create new tetrabutylammonium copper halide phosphors, which exhibit effective warm white light emission with luminescence peaks at 494 and 654 nm.
  • - The new phosphors achieve a high photoluminescence quantum yield of 93.7%, with a WLED CIE coordinate of (0.3620, 0.3731), a CRI of 89, and a low CCT of
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The synthesis of α-CsPbI perovskite quantum dots (QDs) with pure red emission around 630 nm is in high demand for display backlight application. However, the phase transition of α-CsPbI to yellow non-emitting δ-CsPbI has been proven to be a great challenge for the classic colloidal synthesis route for perovskite QDs in octadecene (ODE). Herein, we report a novel colloidal synthesis route by replacing ODE with lauryl methacrylate (LMA) as the reaction solvent to improve the solubility of precursors, resulting in small sized α-CsPbI QDs with a diameter of only 4.

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Background: Underwater endoscopic mucosal resection (UMER) is a new method of endoscopic resection to completely remove the lesion without submucosal injection. But few attempts have been carried out for rectal neuroendocrine tumors (rectal NETs).

Methods: We retrospectively investigated data on the tumor characteristics and outcomes of patients with ≤ 10 mm rectal NETs who underwent UEMR or endoscopic submucosal dissection (ESD) from January 2019 to June 2021 in our institute.

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BRCA1 deficient breast cancers are aggressive and chemoresistant due, in part, to their enrichment of cancer stem cells that can be generated from carcinoma cells by an epithelial-mesenchymal transition (EMT). We previously discovered that BRCA1 deficiency activates EMT in mammary tumorigenesis. How BRCA1 controls EMT and how to effectively target BRCA1-deficient cancers remain elusive.

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Manganese-doped perovskite nanocrystals (NCs) have been synthesized by a novel two-step hot-injection strategy with an unprecedented Mn doping efficiency of 48.5%, bright orange emission under ultraviolet light and X-ray excitation and a photoluminescence quantum yield of 84.4%, making them excellent luminescent materials.

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Functional loss of is associated with poorly differentiated and metastatic breast cancers that are enriched with cancer stem cells (CSCs). CSCs can be generated from carcinoma cells through an epithelial-mesenchymal transition (EMT) program. We and others have previously demonstrated that BRCA1 suppresses EMT and regulates the expression of multiple EMT-related transcription factors.

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Recently, two-dimensional (2D) metal halide perovskite materials with wide application in perovskite-based solar cells have attracted significant attention. Among them, 2D mixed lead-tin perovskites have not been systematically explored. Herein, we synthesize a 2D phenethylammonium (PEA) tin-lead bromide perovskite, PEASn Pb Br, a simple solution-phase approach without toxic reagents and high temperatures.

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Background: Basal-like breast cancers (BLBCs) are a leading cause of cancer death due to their capacity to metastasize and lack of effective therapies. More than half of BLBCs have a dysfunctional BRCA1. Although most BRCA1-deficient cancers respond to DNA-damaging agents, resistance and tumor recurrence remain a challenge to survival outcomes for BLBC patients.

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  • * The study found that the dual-target MDM2/MDMX inhibitor significantly reversed DOX resistance in resistant breast cancer cells and enhanced the effects of DOX by promoting cell death and stopping cell growth.
  • * Mechanisms behind the effectiveness included changes in protein expression linked to reduced drug resistance, activated by the TAK1-p38 MAPK signaling pathway, indicating that this dual-target inhibitor could be a new approach for treating resistant breast cancer.
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High rates of de novo lipid synthesis have been discovered in certain kinds of tumours, including gallbladder cancer (GBC). Unlike several other tumours, GBC is highly insensitive to standard adjuvant therapy, which makes its treatment even more challenging. Although several potential targets and signalling pathways underlying GBC chemoresistance have been revealed, the precise mechanisms are still elusive.

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Purpose: This study examined the tumor expression of programmed cell death ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) in patients with GEP-NEN. This study aims to reveal the relationship of their expression with clinicopathological characteristics and prognosis.

Methods: PD1 and PD-L1 expression in tumors from 120 GEP-MEN patients was evaluated using immunohistochemistry.

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Impaired mitochondrial function and activation of NLRP3 inflammasome cascade has a significant role in the pathogenesis of myocardial ischemia-reperfusion (IR) injury. The current study investigated whether eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or their corresponding CYP epoxygenase metabolites 17,18-epoxyeicosatetraenoic acid (17,18-EEQ) and 19,20-epoxydocosapentaenoic acid (19,20-EDP) protect against IR injury. Isolated mouse hearts were perfused in the Langendorff mode with vehicle, DHA, 19,20-EDP, EPA, or 17,18-EEQ and subjected to 30 min of ischemia and followed by 40 min of reperfusion.

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Background: Estrogen promotes breast cancer development and progression mainly through estrogen receptor (ER). However, blockage of estrogen production or action prevents development of and suppresses progression of ER-negative breast cancers. How estrogen promotes ER-negative breast cancer development and progression is poorly understood.

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In this study, we reported the one-step synthesis of chitosan-Fe(OH) beads without the use of acid solvent, which could be used as effective adsorbents for anionic dyes removal. The preparation process was easy and green. The as-prepared beads were characterized for structural and morphological analysis in detail using several techniques, such as Scanning Electron Microscope, Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, X-ray photoelectron spectroscopy and Thermogravimetric analysis.

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This communication describes a facile hot-injection method for the synthesis of novel micrometer-size formamidinium lead bromide perovskite (FAPbBr3) nanosheets of monolayer thickness (around 2.4 nm). Due to the strong quantum confinement effect, the as-synthesized large-sized perovskite nanosheets displayed an unprecedented extremely blue-shifted first sharp excitonic absorption peak at 435 nm and an emission peak at 437 nm, as compared to that of bulk FAPbBr3 crystals at 551 nm.

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The present study assessed the role of metastasis-associated protein 1 (MTA1) in epithelial to mesenchymal transition (EMT) and metastasis in non-small-cell lung cancer (NSCLC) cells using a normal lung epithelium cell line, three NSCLC cell lines, a mouse NSCLC model, and 56 clinical NSCLC samples. We observed that MTA1 overexpression decreased cellular adhesion, promoted migration and invasion, and changed cytoskeletal polarity. MTA1 knockdown had the opposite effects.

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Recently, electrically conductive biomaterial scaffolds have shown great potential in tissue regeneration. Herein, we reported an electrically conductive polyaniline (PANI) coated poly(ε-caprolactone) (PCL) electrospun micron-fiber scaffold for the enhanced attachment and proliferation of human umbilical vein endothelial cells (HUVECs) under electrical stimulation conditions. After the O plasma treatment toward PCL electrospun fiber, PANI could be polymerized onto their surfaces successfully.

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