Publications by authors named "Chuyan Yuan"
Nucleic Acids Res
October 2024
Article Synopsis
- The BEN domain is a newly identified DNA-binding domain found in various species, including nine types present in humans, primarily involved in chromatin-related functions.
- The study focused on understanding the DNA recognition mechanisms of two specific BEN domain proteins, NACC1 and BANP, revealing how they interact with DNA—NACC1 binds to CATG motifs, while BANP targets unmethylated CpG motifs.
- Key findings include the crystal structures of NACC1 and BANP with their DNA substrates, showcasing that BANP requires oligomerization for effective binding to unmethylated CGCG motifs, shedding light on its role as a CpG island-binding protein and paving the way for future research on BEN domain proteins' physiological functions.
