Publications by authors named "Chuxiao Mao"
Currently, researchers are exploring the conversion of astrocytes into functional mature neurons and gradually exploring the conversion of glioma into neurons. We report that SLCDS (SB431542, LDN193189, CHIR99021, DAPT, and SKL2001) has been shown to convert human glioma cells into mature neuron-like cells. The converted cells exhibited upregulation of DCX, TuJ1, MAP2, NeuN, and GAD67, while the expressions of EGFR, PDGFR, Ki67, and vimentin were inhibited.
View Article and Find Full Text PDFArticle Synopsis
- Spinal Ependymoma (SP-EP) is the most common tumor in the spinal cord, and early diagnosis can significantly improve patient outcomes, which led to a study focused on analyzing RNA sequencing data to identify crucial genes associated with the disease and develop a prognostic tool.
- The study used data from the Gene Expression Integrated Database (GEO) to find differentially expressed genes (DEGs) between SP-EP tumors and normal controls, incorporating machine learning to pinpoint immune-related genes and using patient data from the SEER database to find predictive factors affecting survival.
- A total of 5,151 DEGs were identified, with further analysis pointing to their involvement in essential cellular functions such as cell cycle regulation, ultimately leading