KRAS Mutation in Pediatric Intracranial Germ Cell Tumors.

Background: Intracranial germ cell tumors (IGCTs) are rare, highly curable neoplasms. KRAS is a gene in the KIT/RAS signaling pathway, and KRAS mutations have been reported in patients diagnosed with IGCTs.

Objectives: To describe the clinicopathologic and molecular features of KRAS mutation and the treatment outcome of children diagnosed with IGCTs.

Risk factors for autism spectrum disorder in the Thai population.

Unlabelled: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder commonly prevalent in children worldwide including Thailand. However, there are very few studies thus far addressing risk factors for ASD in Thai children. This case-control study aims to investigate whether various risk factors especially socioeconomic status, advanced parental age (age >35 years), perinatal factors, maternal autoimmune diseases, and family history of neuropsychiatric illnesses were associated with the risk of having an offspring with ASD.