[The automatization of the control over the processes determining the risk of HIV-infection spreading among servicemen].

The possibilities of the control over the processes determining the HIV-infection spreading risk are considered. In the view of that the automated system which enables to evaluate risk factors predetermining the appearance of new infection cases was proposed. These factors are systematised in a multilevel database.

[The methodological aspects in enhancing the efficacy of the epidemiological surveillance of HIV infection].

Using a systems approach, the authors examined the main principles underlying an expert-based system for epidemiological surveillance over HIV infection. The principle objective is to control the processes which precede the occurrence of new infected cases and further spread of HIV infection. Accordingly, the system should address the following: epidemiological diagnosis and prediction of HIV incidence and spread, development of optimal preventive anti-epidemiological measures, research into how the infection spread.

[Study of the combined action of an antibiotic and an immunostimulator using mathematical modeling].

A mathematical model of antibiotic and immunostimulator (IMS) combined effect on various elements of the immune system and general state of patients with infectious diseases is described. The model was constructed as a system including 6 usual differential equations of the 1st order. With the use of this model and a computer many diverse variants of infection development under conditions of treatment with IMS at the background of antibiotic therapy were modeled.

[Use of mathematical theory in experiments evaluating the protective properties of antimicrobial preparations].

Mathematical design of multifactorial experiments in investigation of protective properties of antimicrobial drugs provided acceleration of preclinical study of new antimicrobial drugs, increasing its level and decreasing its size and cost. The advantage of the experiment mathematical design in investigation and estimation of protective properties of antimicrobial drugs was shown on a model of doxycycline chemotherapy of experimental anthracic infection caused by the vaccinal strain of the causative agent in albino mice. Second order quasi-D-optimal plans for 3-, 4- and 5-factorial experiments are presented and variation ranges of the main factors affecting chemotherapeutic activity of antimicrobial drugs are recommended: daily doses of the antibiotic, the inoculum size, the time of chemotherapy initiation after inoculation and the period of the preventive treatment.

[Determination of the criteria for selecting the optimal obsidan and hypothiazide treatment regimen in hypertension based on mathematical modelling data].

Criteria for the choice of drug dosage are established. In mild changes of pulmonary hemodynamics in patients with hypertensive disease, minimum doses of hypothiazide are recommended, while treatment should be conducted with obsidan, for the main part. In considerable attendant disorders of pulmonary hemodynamics the dose of hypothiazide should be proportionally increased, while the dose of obsidan is reduced.

[Daily form of rest in the catfish Ictalurus nebulosus and the frog Rana temporaria].

By means of recording the cardiac rhythm, respiration rate and motor activity in unrestrained animals, studies have been made on the dynamics of formation of cataleptic-like immobilization in the teleost I. nebulosus. Rhythmic illumination at a rate 3/min.

[Circadian cycles of wakefulness and rest in Rana temporaria frogs].

In the diurnal activity of the frog R. temporaria, rest and awakefulness stages were investigated. Resting stage was differentiated into daily and nocturnal phases.