Shift of N-MYC Oncogene Expression in AML Patients Carrying the FLT3-ITD Mutation.

Mutations in the gene not only lead to abnormalities in its structure and function, but also affect the expression of other genes involved in leukemogenesis. This study evaluated the expression of genes that are more characteristic of neuroblastoma but less studied in leukemia. oncogene expression was found to be more than 3-fold higher in primary AML patients carrying the mutation compared to carriers of other mutations as well as patients with normal karyotype ( = 0.

Emergence of Candida auris in Russia.

This paper reports the emergence of Candida auris infections in an intensive care unit at a hospital in Moscow. Forty-nine cases were diagnosed in 2016-2017, and the risk factors and antifungal susceptibilities are described. The 30-day all-cause mortality for 19 bloodstream infections in patients who did not receive appropriate antifungal therapy was 42.

Structural analysis of MHC alleles in an RSV tumour regression chicken using a BAC library.

The chicken major histocompatibility complex (MHC-B locus) has a strong association with resistance and susceptibility to numerous diseases. We have found a B haplotype designated WLA that associated with the regression of tumours caused by Rous sarcoma virus J strain (RSV-J). Haplotype WLA was identical to the regressive B6 haplotype when partial genotyping was performed (Poultry Science, 89, 2010, 651).

Genotypes of chicken major histocompatibility complex B locus associated with regression of Rous sarcoma virus J-strain tumors.

The chicken MHC-B locus affects the response to several strains of Rous sarcoma virus (RSV). We evaluated the association between haplotypes of the MHC-B locus and responses to the J strain of RSV by using an F(2) experimental resource family constructed with tumor-regressive (White Leghorn) and tumor-progressive (Rhode Island Red) chickens. The MHC-B haplotypes were determined by genotyping of the microsatellite marker LEI0258 and MHC-B locus class I alpha chain 2 (BF2).

[Destabilizing effect of chicken selection using the functional adrenal reserves criteria].

Chicken lines produced by divergent selection for the functional adrenal reserves showed significant between-line differences in the content of corticosterone and other hormones (thyroxin, progesterone), as well as in body weight, early maturation, and egg yield. DNA fingerprinting with the pGB725 probe revealed molecular changes in genomic DNA of the chicken lines subjected to plus and minus selection. The genetic distances between the original population and the selected chicken lines, which were estimated from the molecular hybridization patterns, reflected the history of breeding.

[Use of the pGB725 probe containing poly-TG-repeats for detecting polymorphic microsatellite loci in the genome of the chicken Gallus gallus domesticus].

Using [32P]-labeled hybridization probe of plasmid pGB725 enriched with poly-TG-pairs of nucleotides, chicken genome fingerprints were obtained. High genetic informativity of hybridization profiles and the possibility of polymorphic loci in the telomeric macrochromosomes' regions was revealed.

[The characteristics of chromosomal distribution and of the variability of the multiply repeating DNA fraction of the genome in Bos taurus L].

The uniform distribution of satellite DNA II and IV has been revealed using in situ hybridization and differential staining in centromeric regions of autosomes. The sex chromosomes have not found such nucleotide blocks. There is only minor satellite IV block inside Y chromosome short arm.

[The effect of high temperature on the frequency of nondisjunction and loss of sex chromosomes in females of Drosophila melanogaster strain I(1)ts403 with a defect in the heat shock protein system].

High temperature (37 degrees C) induces sex chromosome non-disjunction and loss in Drosophila melanogaster females l(1)ts403 with the defect in heat-shock protein system. The same temperature has no effect on the females from the T line and other earlier studied lines.