Publications by authors named "Chunyue Wang"
Purpose: Effective cancer treatment relies on the precise deployment of clinical imaging techniques to accurately treat tumors. One highly representative technology among these is multi-imaging guided phototherapy. This work introduces a new and innovative theranostic drug that combines near-infrared (NIR) irradiation-induced photodynamic therapy (PDT) and photothermal therapy (PTT) to treat malignancies.
View Article and Find Full Text PDFBackground/objectives: Depression is a prevalent worldwide mental health disorder that inflicts significant harm to individuals and society. is an edible fungus that contains a variety of nutrients, including polysaccharides. This study aims to investigate the monosaccharide composition and molecular weight of the polysaccharide (DDP-B1), followed by an exploration of its antidepressant effects in chronic unpredictable mild stress (CUMS) mice.
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- * A large cohort of 9438 MetS patients was analyzed over an average follow-up period of about 107 months, where 1929 deaths were recorded, indicating a significant correlation between elevated SHR and higher mortality rates.
- * The findings suggest a U-shaped relationship where both low and high SHR values may increase mortality risk, emphasizing the importance of monitoring SHR in managing MetS patients' health outcomes.
Background: Leaf senescence (LS), the final phase in leaf development, is an important and precisely regulated process crucial for plant well-being and the redistribution of nutrients. It is intricately controlled by various regulatory factors, including WRKY transcription factors (TFs). WRKYs are one of the most significant plant TF families, and several of them are differentially regulated and important during LS.
View Article and Find Full Text PDFIrinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial.
Signal Transduct Target Ther
September 2024
Article Synopsis
- Liposomal irinotecan (HR070803) combined with 5-fluorouracil and leucovorin shows enhanced overall survival in patients with advanced pancreatic cancer previously treated with gemcitabine-based therapies, as demonstrated in a phase 3 study.
- The trial involved 298 patients, showing a median overall survival of 7.4 months for the HR070803 group compared to 5.0 months for the placebo group, with statistically significant results.
- While there were some adverse events, such as increased liver enzyme levels and decreased white blood cell counts, the safety profile was manageable, with no treatment-related deaths in the HR070803 group, highlighting its potential as a second-line treatment option for this patient
Article Synopsis
- Triple negative breast cancer (TNBC) is a challenging type of breast cancer that requires innovative treatment approaches due to its poor prognosis.
- Researchers developed a nanoplatform called PTFTH that utilizes gene therapy, photothermal therapy, and ferroptosis combined into one solution, targeting cancer cells specifically.
- In laboratory tests, PTFTH demonstrated effective tumor treatments by increasing oxidative stress in cancer cells and showed promise for imaging techniques like ultrasound and MRI, presenting a multi-faceted approach to combatting TNBC.
Anti-inflammatory and antioxidant effects play crucial roles in the recovery of benign prostatic hyperplasia (BPH). Wenshenqianlie (WSQL) capsule, a typical traditional Chinese medicine formulation combining 14 Chinese herbs, has been reported to exert tonic effects on the kidneys and improve clinical symptoms of BPH. However, its potential antioxidative and anti-inflammatory properties and effects on the improvement of hormone levels have not been reported in depth.
View Article and Find Full Text PDFThe immunosuppressive tumor microenvironment (TME) has become a major challenge in cancer immunotherapy, with abundant tumor-associated macrophages (TAMs) playing a key role in promoting tumor immune escape by displaying an immunosuppressive (M2) phenotype. Recently, it was reported that M1 macrophage-derived nanovesicles (M1NVs) can reprogram TAMs to an anti-tumor M1 phenotype, thereby significantly alleviating the immunosuppressive TME and enhancing the anti-tumor efficacy of immunotherapy. Herein, we developed M1NVs loaded with mesoporous dopamine (MPDA) and indocyanine green (ICG), which facilitated the recruitment of M2 TAMs through synergistic photothermal and photodynamic therapy.
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- The study looked at the FIB-4 index, which helps doctors see how bad liver disease might be in people with heart issues, specifically hypertrophic cardiomyopathy (HCM).
- Researchers divided 187 HCM patients into two groups based on their FIB-4 scores to see how many had serious heart problems or died over time.
- They found that patients with higher FIB-4 scores (2.37 or more) had more heart issues and a greater chance of dying from heart problems compared to those with lower scores.
Alzheimer's disease (AD) is a common neurodegenerative disorder. Polysaccharides have been scientifically demonstrated to possess neuroprotective properties. In this study, a polysaccharide was isolated from the fruiting bodies of Hericium coralloides using hot water extraction and purified using column chromatography.
View Article and Find Full Text PDFWith the increasing occurrence of global warming, drought is becoming a major constraint for plant growth and crop yield. Plant cell walls experience continuous changes during the growth, development, and in responding to stressful conditions. The plant WRKYs play pivotal roles in regulating the secondary cell wall (SCW) biosynthesis and helping plant defend against abiotic stresses.
View Article and Find Full Text PDFThe polysaccharide, RGP2, was isolated from Russula griseocarnosa and its immunostimulatory effects were confirmed in cyclophosphamide (CTX)-induced immunosuppressed mice. Following purification via chromatography, structural analysis revealed that RGP2 had a molecular weight of 11.82 kDa and consisted of glucose (Glc), galactose (Gal), mannose, glucuronic acid and glucosamine.
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- - The study explores the relationship between the triglyceride-glucose (TyG) index, a measure of insulin resistance, and myocardial ischemia in patients with ischemia and no obstructive coronary artery disease (INOCA), finding that a higher TyG index correlates with an increased occurrence of abnormal myocardial perfusion imaging (MPI).
- - Out of 332 INOCA patients, 34% demonstrated abnormal MPI, and those in the highest TyG index group exhibited the highest rates of ischemia and major adverse cardiac events (MACE) during a follow-up period of approximately 35 months.
- - The findings suggest that the TyG index could serve as a predictor for poor outcomes in INOCA patients, with higher
Article Synopsis
- Urban water distribution networks (WDNs) have problems like leaks and pipe bursts, making it important to monitor them effectively.
- Recently, researchers are using new technology called the Internet of Things (IoT) and wireless sensors to keep track of these networks.
- The study suggests a new way to decide where to place sensors by looking at both how the water flows and how the network is connected, and tests show it works better than some old methods.
Background: Congenital dysfibrinogenemia (CD) is a rare hereditary coagulation disorder resulting from mutations in fibrinogen genes. CD primarily presents with bleeding symptoms, but it can also lead to thrombotic events, including ischemic stroke.
Case Presentation: This report describes the case of a 52-year-old Chinese man who was admitted to the hospital twice due to recurrent cerebral infarction, characterized by sudden speech impairment and weakness in the right upper extremity.
Article Synopsis
- In eukaryotic cells, microtubules are important for how cells change and make decisions about their functions.
- End-binding (EB) proteins help control microtubule activity and are key for cell division and separating chromosomes.
- Researchers found that a protein called EB1, along with others, helps to organize cell parts needed for this process, and changes in EB1 can affect how well cells divide accurately.
Article Synopsis
- Accurate chromosome segregation during cell division relies on structures called kinetochores that help pull chromosomes apart using tiny filaments called microtubules.* -
- A group of proteins called CCAN, which includes CENP-W and CENP-T, is important for connecting the DNA at the center of the chromosomes to these microtubules.* -
- When a protein called Aurora B adds a chemical tag to CENP-W, it makes CENP-W and CENP-T work better together, helping ensure that chromosomes are properly lined up and separated during cell division.*
Article Synopsis
- BEP2 is a special sugar found in mushrooms that helps improve learning and memory in mice by reducing harmful brain proteins and inflammation.
- In studies, BEP2 changed the types of bacteria in the mice's guts, making some families grow more while reducing others.
- It also influenced several important substances in the body, helping to control inflammation and support brain health.
Article Synopsis
- Scientists are studying how different parts of the brain develop during pregnancy to understand their special roles.
- They found that certain cells called radial glia, around 8 weeks of pregnancy, are important for this development and help create different types of brain cells.
- The research shows that interactions between types of brain cells can affect how neurons grow and specialize in different areas of the brain.
Background: The edible fungus (ADe) is commonly employed in traditional medicine for intestinal disorders; however, its inhibitory effect on colitis-associated colorectal cancer (CAC) and the underlying mechanisms remain unexplored. (2) Methods: The inhibitory effect of ADe on CAC was investigated using a mouse model induced by azoxymethane/dextran sulfate sodium.
Results: ADe effectively suppressed the growth and number of intestinal tumors in mice.
Background: Apoptosis resistance of hepatocellular carcinoma (HCC) often leads to treatment failure. Nonetheless, overcoming the resistance of HCC to apoptosis by inducing necroptosis of tumor cells to bypass the apoptotic pathway may be a promising treatment strategy. Sonodynamic therapy (SDT) has broad prospects in disease treatment because of its noninvasive characteristic and spatiotemporal control.
View Article and Find Full Text PDFPurpose: Sonodynamic therapy (SDT) is a promising and significant measure for the treatment of tumors. However, the internal situation of hepatocellular carcinoma (HCC) is complex, separate SDT treatment is difficult to play a good therapeutic effect. Here, we used SDT combined with MG-132 to mediate apoptosis and autophagy of HCC cells to achieve the purpose of treatment of cancer.
View Article and Find Full Text PDFBackground: Despite the clinical efficacy of immunotherapy in treating malignant tumors, its effectiveness is often hampered by the immunosuppressive nature of the tumor microenvironment (TME). In this study, we propose the design of a nanoscale ultrasound contrast agent capable of triggering macrophage polarization and immunogenic cell death (ICD) for the treatment of hepatocellular carcinoma (HCC) through sonodynamic treatment (SDT) and immunotherapy.
Methods: The re-educator (designated as ICG@C3F8-R848 NBs) is composed of the Toll-like receptor agonist resiquimod (R848) and the sonosensitizer Indocyanine green (ICG), utilizing nanobubbles (NBs) as carriers.
Article Synopsis
- Shugoshin-1 (Sgo1) helps keep chromosomes together during cell division, which is important for making sure each new cell gets the right number of chromosomes.
- Sgo1's position at the centromere (the middle part of a chromosome) depends on a special modification of another protein called histone H2A.
- The study found that a protein called CENP-A is necessary for Sgo1 to be at the centromere, and if certain parts of Sgo1 are changed, it can mess up the whole chromosome separation process.