Complete mitochondrial genome of Agropyron cristatum reveals gene transfer and RNA editing events.

Background: As an important forage in arid and semi-arid regions, Agropyron cristatum provides livestock with exceptionally high nutritional value. Additionally, A. cristatum exhibits outstanding genetic characteristics to endure drought and disease.

Rotavirus outbreaks in China, 1982-2021: a systematic review.

Background: Rotavirus is globally recognized as an important cause of acute gastroenteritis in young children. Whereas previous studies focused more on sporadic diarrhea, the epidemiological characteristics of rotavirus outbreaks have not been systematically understood.

Methods: This systematic review was carried out according to the Preferred Reporting Items for Systematic Review and Meta-Analysis standards, WANFANG, China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases were searched from database inception to February 20, 2022.

AI: Bridging Ancient Wisdom and Modern Innovation in Traditional Chinese Medicine.

The pursuit of groundbreaking health care innovations has led to the convergence of artificial intelligence (AI) and traditional Chinese medicine (TCM), thus marking a new frontier that demonstrates the promise of combining the advantages of ancient healing practices with cutting-edge advancements in modern technology. TCM, which is a holistic medical system with >2000 years of empirical support, uses unique diagnostic methods such as inspection, auscultation and olfaction, inquiry, and palpation. AI is the simulation of human intelligence processes by machines, especially via computer systems.

GDF-15 is a potential candidate biomarker for an elevated risk of cardiotoxicity in breast cancer patients receiving neoadjuvant dual anti-HER2 therapy.

Objective: Growth differentiation factor 15 (GDF-15) is a stress-responsive cytokine that regulates myocardial injury, cardiac overloading pressure, and inflammation and is related to the risk of cardiovascular diseases and events. The current study aimed to investigate the correlation of GDF-15 levels with clinical features, biochemical indices, and especially the risk of cardiotoxicity in breast cancer patients receiving neoadjuvant dual anti-HER2 therapy.

Methods: A total of 103 HER2-positive breast cancer patients who underwent neoadjuvant dual anti-HER2 therapy (trastuzumab and pertuzumab plus chemotherapy) were included.

Impulse oscillometry in the diagnosis of cough variant asthma in children.

Background: Cough variant asthma (CVA) is one of the most common causes of chronic cough in children worldwide. The diagnosis of CVA in children remains challenging. This study aimed to assess the diagnostic utility of impulse oscillometry (IOS) pulmonary function in children with CVA.

Complete mitochondrial genome of the endangered (Prunoideae, Rosaceae) in China: characterization and phylogenetic analysis.

Introduction: (Prunoideae: Rosaceae), a relic shrub with strong resistance and multiple application values, is endangered in China. Extensive research had been devoted to gene expression, molecular markers, plastid genome analysis, and genetic background investigations of . However, the mitochondrial genome of this species has not been systematically described, owing to the complexity of the plant mitogenome.

Total saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance .

Objective: Intestinal flora homeostasis in rats with type 2 diabetes mellitus (T2DM) was evaluated to explore the effects of total saponins (TAS) on hepatic insulin resistance (IR).

Methods: Six-week-old male Sprague-Dawley rats were fed high-fat and high-sugar diet for 4 weeks and intraperitoneally injected with streptozotocin to induce T2DM, and they were then randomly divided into control, model, metformin, and TAS groups. Stool, serum, colon, and liver samples were collected after 8 weeks of drug administration for relevant analyses.

Spirometry in the diagnosis of cough variant asthma in children.

Objective: This study aimed to assess the diagnostic utility of spirometry, particularly focusing on small airway parameters, in children with cough variant asthma (CVA).

Methods: This study included children aged 5-12 years with a diagnosis of CVA. Pre- and postbronchodilation spirometry parameters, including FEV %pred, FVC%pred, FEV /FVC%pred, PEF%pred, FEF %pred, FEF %pred, FEF %pred, MMEF%pred, were recorded.

Synergistic Amplification of Ferroptosis with Liposomal Oxidation Catalyst and Gpx4 Inhibitor for Enhanced Cancer Therapy.

As a distinctly different way from apoptosis, ferroptosis can cause cell death through excessive accumulation of lipid peroxide (LPO) and show great potential for cancer therapy. However, efficient strategies for ferroptosis therapy are still facing great challenges, mainly due to insufficient endogenous H O or relatively high pH value for Fenton reaction-dependent ferroptosis, and the high redox level of tumor cells attenuates the oxidation therapy. Herein, an efficient lipid-based delivery system to load oxidation catalyst and glutathione peroxidase 4 (Gpx4) inhibitor is orchestrated, intending to amplify Fenton reaction-independent ferroptosis by bidirectional regulation of LPO accumulation.

Complete Chloroplast Genome of (Papilionoideae: Fabaceae): Comparative and Phylogenetic Analysis.

is an endemic forage grasses in China with high ecological value. In this study, the complete chloroplast genome of was sequenced using Illumina paired-end sequencing. The chloroplast genome was 123,100 bp and comprised 105 genes, including 74 protein-coding genes, 4 rRNA-coding genes, and 27 tRNA-coding genes.

Comparative and Phylogenetic Analysis of Complete Chloroplast Genomes in (Triticodae, Poaceae).

is a perennial genus that belongs to the tribe Triticeae (Poaceae) which has an adaptive capacity to ecological conditions and strong resistance to cold, drought, and salinity. Most species are fine herbs that can be used for agriculture, conservation, and landscaping. Due to confusion taxonomy within genera, the complete chloroplast (cp) genome of 13 species was sequenced, assembled, and compared with those of three other previously published species (, , and ) to clarify the issue.

Efficacy and safety of neoadjuvant pyrotinib plus docetaxel/liposomal doxorubicin/cyclophosphamide for HER2-positive breast cancer.

Objective: Pyrotinib is a novel EGFR/HER2 dual tyrosine kinase inhibitor developed in China, while its role in neoadjuvant therapy of HER2-positive (HER2) breast cancer lacks evidence. The current study aimed to explore the efficacy and safety of neoadjuvant pyrotinib plus docetaxel/liposomal doxorubicin/cyclophosphamide (TAC) for HER2 breast cancer.

Methods: A total of 27 HER2 breast cancer patients received neoadjuvant pyrotinib plus TAC for 6 cycles, then surgery was performed.

Sanghuang Tongxie Formula Ameliorates Insulin Resistance in Through Regulating PI3K/Akt Signaling.

Insulin resistance (IR) is a pivotal pathological characteristic that affects the occurrence and development of type 2 diabetes mellitus (T2DM). Thus, the effective control of IR is of great significance for diabetes prevention and treatment. Traditional Chinese medicine (TCM) represents a valuable tool handed down to the world by the Chinese nation and has a long history of use for diabetes clinical therapy.

Rapid bilateral visual loss as the initial clinical manifestation in idiopathic hypertrophic cranial pachymeningitis.

A 59-year-old patient presented with 4-day acute painless bilateral visual loss, MRI results showed dura enhancement of the frontal, anterior cranial fossa. The patient was considered to have idiopathic hypertrophic cranial pachymeningitis based on laboratory tests and MRI data. After treatment with hormones, the visual acuity obviously improved.

Nanopore sequencing approach for variation detection of a live attenuated Newcastle disease virus vaccine.

Live attenuated Newcastle disease virus (NDV) vaccines have been used widely to protect chickens against Newcastle disease. However, the vaccine issues caused by genome mutations can seriously affect poultry health. In this study, the authors demonstrate the use of nanopore sequencing technology for rapid genome determination and variation analysis from a live attenuated NDV vaccine.

A Mixture of Baicalein, Wogonin, and Oroxylin-A Inhibits EMT in the A549 Cell Line the PI3K/AKT-TWIST1-Glycolysis Pathway.

Non-small cell lung cancer (NSCLC) is a worldwide disease with a high morbidity and mortality rate, which is most derived from its metastasis. Some studies show that the epithelial-mesenchymal transition (EMT) process promotes lung cancer cell migration and invasion, leading to NSCLC metastasis. Total flavonoid aglycones extract (TFAE) isolated from was reported to inhibit tumor growth and induce apoptosis.

Characterization and Comparative Analysis of Complete Chloroplast Genomes of Three Species From the Genus (Leguminosae).

Astragalus is the largest genus in Leguminosae. Several molecular studies have investigated the potential adulterants of the species within this genus; nonetheless, the evolutionary relationships among these species remain unclear. Herein, we sequenced and annotated the complete chloroplast genomes of three species-, var.

Research on the longitudinal mechanical behaviours of subway turnouts of large slope under train braking force.

To study subway turnouts' adaptability to steep gradients, a finite element model of a metro No. 9 simple turnout was established. The main works include: (1) The train's most unfavourable loading condition was modelled.

Indoor simulation test research on cumulative longitudinal displacement of rail based on force and displacement sensors data collection.

The train sometimes needs to brake frequently on the turnout, although the braking force does not exceed the limit resistance of fastener, cumulative displacement of rail occurs because of the long-term effect of the train brakes, thus, the relationship between the cumulative displacement of rail and the number of train braking actions should be explored. Aiming at the spring bar type III fastener, a 1:1 physical indoor simulation test was carried out, and an electromagnetic relay device was used to simulate the train load, force, and displacement sensors for data collection. Then a single load no more than the maximum resistance of fastener was applied to the rail end to explore the relationship between the number of loads and the rail cumulative deformation.

αA-Crystallin inhibits optic nerve astrocyte activation induced by oxygen-glucose deprivation in vitro.

Aims: A previous study reported that intravitreal injection of αA-crystallin inhibits glial scar formation after optic nerve traumatic injury. The purpose of this study was to investigate the effect of αA-crystallin on optic nerve astrocytes induced by oxygen glucose deprivation (OGD) in vitro.

Materials And Methods: Optic nerve astrocytes from newborn Long Evans rats were cultured with αA-crystallin (10 g/l) to detect the effects of αA-crystallin on astrocytes.

Manganese-Based Nanoactivator Optimizes Cancer Immunotherapy Enhancing Innate Immunity.

Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are essential components of the innate immune sensors to cytosolic DNA and elicit type I interferon (IFN). Recent studies have revealed that manganese (Mn) can enhance cGAS and STING activation to viral infection. However, the role of Mn in antitumor immunity has not been explored.

Spleen-kidney supplementing formula alleviates insulin resistance via regulating AKT/glycogen synthase kinase 3β pathway in rats with type 2 diabetic induced by high-fat diet.

Objective: To explore the molecular mechanism underpinning the action by investigating its effect on glycogen content and AKT (also known as protein kinase B)/glycogen synthase kinase 3β (GSK- 3β) pathway in the liver of rats with type 2 diabetic induced by high-fat diet.

Methods: The rat model of type 2 diabetes was induced by high-fat diet and multiple low-dose streptozotocin injection. Diabetic rats were divided into five groups: the model control group, the Metformin group, spleen-kidney supplementing formula groups of low, medium and high doses.