Investigating the Process of Autoimmune Inner Ear Disease: Unveiling the Intricacies of Pathogenesis and Therapeutic Strategies.

Autoimmune inner ear disease (AIED) is a rare condition characterized by immune-mediated damage to the inner ear, leading to progressive sensorineural hearing loss (SNHL) and vestibular symptoms such as vertigo and tinnitus. This study investigates the pathogenesis and therapeutic strategies for AIED through the analysis of three cases with different underlying autoimmune disorders: rheumatoid arthritis, relapsing polychondritis, and IgG4-related disease. The etiology of AIED involves complex immunopathological mechanisms, including molecular mimicry and the "bystander effect," with specific autoantibodies, such as those against heat shock protein 70 (HSP70), playing a potential role in cochlear damage.

Numerical Analysis of the Cell Droplet Loading Process in Cell Printing.

Cell printing is a promising technology in tissue engineering, with which the complex three-dimensional tissue constructs can be formed by sequentially printing the cells layer by layer. Though some cell printing experiments with commercial inkjet printers show the possibility of this idea, there are some problems, such as cell damage due the mechanical impact during cell direct writing, which include two processes of cell ejection and cell landing. Cell damage observed during the bioprinting process is often simply attributed to interactions between cells and substrate.

Anisotropic Hyperelastic Strain Energy Function for Carbon Fiber Woven Fabrics.

The present paper introduces an innovative strain energy function (SEF) for incompressible anisotropic fiber-reinforced materials. This SEF is specifically designed to understand the mechanical behavior of carbon fiber-woven fabric. The considered model combines polyconvex invariants forming an integrity basisin polynomial form, which is inspired by the application of Noether's theorem.

Peripheral enthesitis assessed by whole-body MRI in axial spondyloarthritis: Distribution and diagnostic value.

Objective: To determine the distribution and diagnostic value of peripheral enthesitis detected by whole-body MRI (WBMRI) in axial spondyloarthritis (axSpA) diagnosis, and to determine the value of the peripheral enthesitis score in axSpA assessment.

Methods: Sixty axSpA patients [mean age of 33.2 (24.

Clinical Value of sTREM-1, PCT, and 1,3--D Glucan in Diagnosis of Immune-Associated Pulmonary Interstitial Disease with Fungal Infection.

Background: Fungal infection in the lungs can cause fungal infectious diseases. This disease develops rapidly and involves a wide range. Pathogenic fungi are also more serious types of pathogenic bacteria.

Prevalence of metabolic syndrome in patients with rheumatoid arthritis in eastern China-A hospital based study.

Objective: The purpose of this hospital clinic based study was to evaluate the potential risk factors associated with the prevalence of MetS in RA population.

Methods: From January 2015 to October 2018, 717 patients with RA and 717 healthy controls who were treated or performed physical examination in Tianjin First Central Hospital were enrolled in this study. The basic disease diagnoses were recorded.

Serum progranulin level is associated with disease activity following orthopedic surgery in rheumatoid arthritis patients.

Background: Few studies have focused on the ability of progranulin to predict postoperative disease activity in rheumatoid arthritis (RA) patients who have undergone surgery. This study evaluated serum progranulin levels in active RA patients and analyzed its relationship with postoperative disease activity.

Methods: One hundred thirty-two patients with active RA and 72 healthy subjects were included in this study.

Drug screening and identification of key candidate genes and pathways of rheumatoid arthritis.

Rheumatoid arthritis (RA), which normally manifests as a multi‑joint inflammatory reaction, is a common immunological disease in clinical practice. However, the pathogenesis of RA has not yet been fully elucidated. Rituximab (RTX) is an effective drug in the treatment of RA, however its therapeutic efficacy and mechanism of action require further investigation.

Analysis of kinematic behavior of pedestrians/cyclists in vehicle collisions using impulse.

In order to further reduce the injury risks to pedestrians/cyclists in vehicle collisions, it is necessary to control pedestrian/cyclist kinematics. To investigate pedestrian/cyclist kinematic behavior from initial contact with the vehicle to the ground contact, it is necessary to evaluate the force interactions between the pedestrian/cyclist body region and the car body during the crash event. Finite element analysis was conducted for models of pedestrians and cyclists being struck by a car around the center, left, and right sides of the front of the vehicle at 40 km/h.

Active vitamin D activates chondrocyte autophagy to reduce osteoarthritis via mediating the AMPK-mTOR signaling pathway.

Osteoarthritis (OA) is a common joint degenerative disease. Vitamin D (VD) is essential for bone health. We hypothesized that active VD could be used as a therapeutic treatment for OA.

Logistic regression analysis of pedestrian casualty risk in passenger vehicle collisions in China.

A large number of pedestrian fatalities were reported in China since the 1990s, however the exposure of pedestrians in public traffic has never been measured quantitatively using in-depth accident data. This study aimed to investigate the association between the impact speed and risk of pedestrian casualties in passenger vehicle collisions based on real-world accident cases in China. The cases were selected from a database of in-depth investigation of vehicle accidents in Changsha-IVAC.