Publications by authors named "Chunyan Zhao"

The study aimed to assess the impacts of ionic liquids (ILs) as innovative alternatives to traditional organic solvents on aquatic environments and human health. Five machine learning methods, including multiple linear regression (MLR), partial least squares regression (PLS), random forest regression (RF), support vector regression (SVR), and extreme gradient boosting (XGBoost), were used to construct the prediction models of the toxicity of ILs to D. magna, D.

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The solitary fibrous tumor of the pleura (SFTP) is a rare intrathoracic neoplasm that commonly originates from the subpleural mesenchymal cells of the visceral pleura and accounts for less than 5% of all pleural tumors. We reported a case of a 54-year-old man with a two-week history of hypoglycemia, a six-month history of productive cough and fatigue, and chronic right chest pain. Radiological techniques revealed a giant intra-thoracic mass with hypervascularization, and pathological staining was carried out to make a definitive diagnosis of SFTP.

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Theabrownin (TB), the primary pigment in Pu-erh tea, has shown potential in alleviating metabolic syndrome (MS), though its precise mechanisms remain unclear. This study investigated the effects of Pu-erh tea water extract (WE) and TB on high-fat diet (HFD)-induced MS in rats, focusing on miRNA regulation and gut microbiota composition. Both WE and TB significantly improved markers of MS, including dyslipidemia, insulin resistance, and inflammation.

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  • - The study aimed to evaluate how effective nanopore sequencing technology is for diagnosing tuberculous meningitis (TBM) using cerebrospinal fluid samples from patients.
  • - Compared to traditional methods like acid-fast staining and culture, nanopore sequencing had a sensitivity of 43.30% and an area under the ROC curve of 0.661, indicating better performance overall.
  • - When nanopore sequencing was used alongside imaging techniques, it achieved the best diagnostic results with increased sensitivity, specificity, and predictive values, showing its potential as a reliable tool for TBM diagnosis.
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Gut microbial dysbiosis, especially bacteriome, has been implicated in Alzheimer's disease (AD). However, nonbacterial members of the gut microbiome in AD, such as the mycobiome, archaeome, and virome, are unexplored. Here, we perform higher-resolution shotgun metagenomic sequencing on fecal samples collected longitudinally from a mouse model of AD to investigate longitudinal and multi-kingdom gut microbiome profiling.

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  • Ultraviolet absorbents (UVs) are chemicals used in products like sunscreens and cosmetics, but they have been found in the environment and may negatively affect human health.
  • The study analyzed the levels of nine different UVs in 87 sunscreen and isolation cosmetic products, revealing high concentrations of UV-P and UV-531, as well as significant skin absorption of UV-328.
  • Additionally, the research explored how UVs interact with skin transport proteins and highlighted concerning levels of UVs absorbed through the skin, suggesting a need for further investigation.
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Plant organs achieve their specific size and shape through the coordination of cell division and cell expansion, processes that are profoundly influenced by environmental cues. Cytokinesis during cell division depends on the position of the cytokinetic wall, but how this process responses to environment fluctuations remains underexplored. Here, we investigated a regulatory module involving C2H2-type zinc finger protein (C2H2-ZFP) in leaf morphology during drought stress.

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Blending two or more materials to create better high-moisture meat analogues has been actively studied in the food science and technology field. Walnut protein is a high-quality plant-based protein resource, yet its full potential remains underexploited. Thus, this study focused on exploring the quality characteristics and fibrous structure formation mechanism of walnut protein (WP) and wheat gluten (WG) meat analogues during high-moisture extrusion cooking process.

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Chinese leaves, rich in verbascosides, were extracted using ultrasound-assisted extraction (UAE) and wall-breaking extraction (WBE) with deep eutectic solvents (Optimal UAE: 55 min, 200 mL/g liquid-solid ratio, 20% moisture, yielding 206.23 ± 0.58 mg GAE/g total phenolic content (TPC) and 1.

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The chicken embryo chorioallantoic membrane (CAM) model has played a crucial role in various aspects of cancer research. The purpose of this study is to help researchers clarify the research direction and prospects of the CAM model. A bibliometric analysis was conducted on the top 100 most cited articles on use of the CAM model in tumour research, retrieved from the Web of Science Core Collection database.

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A 61-year-old woman with diffuse large B-cell lymphoma received a fluorine-18-deoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG PET/CT) for staging. Because of the obvious uptake of [¹⁸F]FDG in the spinal cord and brain, a positron emission tomography/magnetic resonance imaging (PET/MRI) was performed after the positron emission tomography/computed tomography (PET/CT). The images showed diffuse [¹⁸F]FDG uptake of the spinal cord and increased T2 signal intensity on MRI, which was suspected to be lymphoma involvement.

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Background: Theabrownin (TB) is a dark brown pigment from Pu-erh tea or other dark teas. It is formed by further oxidization of theaflavins and thearubigins, in combination with proteins, polysaccharides, and caffeine etc. TB is a characteristic ingredient and bioactive substance of Pu-erh tea.

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This study aimed to identify the key volatile compounds in two types of processed arabica coffee husk tea, elucidate their olfactory characteristics, and investigate their antioxidant and anti-inflammatory activities. Sensory evaluation indicated differences between the two groups. A total of 64 and 99 compounds were identified in the C and FC groups, respectively, with 5 identified as key aroma compounds (ROAV≥1).

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Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths. With the development of screening, patient selection and treatment strategies, patients' survival outcomes and living quality significantly improved. However, some patients still have local recurrence or residual tumors after receiving definitive therapies.

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Although caffeine generally offers benefits to human health, its impact on bone metabolism remains unclear. This study aimed to systematically evaluate the long-term effects of caffeine administration on osteoclasts, osteoblasts, and ovariectomy-induced postmenopausal osteoporosis (OP). Our findings revealed that 3.

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  • The study aimed to assess how effective third-generation nanopore sequencing is for diagnosing pulmonary tuberculosis (TB) in patients with diabetes mellitus suspected of having the disease.
  • Researchers collected samples from patients and compared nanopore sequencing results to traditional diagnostic methods like acid-fast bacilli smear and Xpert MTB/RIF.
  • Findings showed that nanopore sequencing significantly enhanced diagnostic accuracy and sensitivity, especially when used in combination with Xpert testing, indicating it could be a better option for TB detection in diabetic patients.
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  • - The study aimed to examine the types, characteristics, and impact of chronic non-communicable diseases (NCDs) while analyzing how sociodemographic factors relate to these diseases through a cross-sectional study of nearly 197,000 medical records from Dongfang in 2021.
  • - Key findings showed that cardiovascular diseases and chronic respiratory diseases were prevalent, with men and older individuals at a higher risk for specific diseases, while unemployed and low-income individuals had varied risks depending on the disease type.
  • - Results indicate that age and gender influence the relationship between job status and the likelihood of experiencing major chronic diseases, highlighting the need for tailored public health strategies.
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Telomere is a protective structure located at the end of chromosomes of eukaryotes, involved in maintaining the integrity and stability of the genome. Telomeres play an essential role in cancer progression; accordingly, targeting telomere dynamics emerges as an effective approach for the development of cancer therapeutics. Targeting telomere dynamics may work through multifaceted molecular mechanisms; those include the activation of anti-telomerase immune responses, shortening of telomere lengths, induction of telomere dysfunction and constitution of telomerase-responsive drug release systems.

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Community nurses play a key role in providing continuous home care for patients with chronic diseases. However, a perfect system of responsibilities and requirements has not yet been formed, and nurses cannot provide high-quality nursing services for home-based patients. We attempted to construct an index of the scope of practice for community nurses providing home-based transitional care for patients with chronic diseases and to guide nurses in playing an active role in transitional care work.

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A computational framework based on placental gene networks was proposed in this work to improve the accuracy of the placental exposure risk assessment of environmental compounds. The framework quantitatively characterizes the ability of compounds to cross the placental barrier by systematically considering the interaction and pathway-level information on multiple placental transporters. As a result, probability scores were generated for 307 compounds crossing the placental barrier based on this framework.

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  • PXY, a receptor kinase in plants, is essential for proper cell division in vascular tissue, particularly under drought conditions.
  • This study focused on two specific PXY genes in hybrid poplar and found they are primarily expressed in the stem's vascular system and linked to drought responses.
  • Overexpressing these PXY genes resulted in increased cambium cell layers and improved drought tolerance, suggesting they help maintain plant growth and resilience in adverse conditions.
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The senescence of fruit is a complex physiological process, with various cell types within the pericarp, making it highly challenging to elucidate their individual roles in fruit senescence. In this study, a single-cell expression atlas of the pericarp of pitaya (Hylocereus undatus) is constructed, revealing exocarp and mesocarp cells undergoing the most significant changes during the fruit senescence process. Pseudotime analysis establishes cellular differentiation and gene expression trajectories during senescence.

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The mutualistic network of plant-pollinator also involves interspecific pollination caused by pollinator sharing. Plant-pollinator networks are commonly based on flower visit observations, which may not adequately represent the actual pollen transfer between co-flowering plant species. Here, we compared the network structure of plant-pollinator interactions based on flower visits (FV) and pollen loads (PL) on the bodies of pollinators and tested how the degree of pollinator sharing in the two networks affected heterospecific pollen transfer (HPT) between plant species in a subalpine meadow.

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  • - The biotransformation of patchouli alcohol resulted in 31 products, including 21 previously unidentified compounds, with their structures identified through advanced spectroscopic techniques.
  • - Key structural features of the new compounds included a Δ double bond in some, a three-membered ring in one, and an epoxy group in another, categorized as patchoulol-type norsesquiterpenoids.
  • - Notably, several biotransformation products exhibited significant anti-influenza virus activity, with effective concentrations (EC) ranging from 2.11 to 20.87 μM.
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Objective: At present, the structure of knowledge in the field of childhood thyroid cancer is not clear enough, and scholars lack a sufficient understanding of the developing trends in this field, which has led to a shortage of forward-looking outputs. The purpose of this research is to help scholars construct a complete knowledge framework and identify current challenges, opportunities, and development trends.

Methods: We searched the literature in the Web of Science Core Collection database on August 7, 2023 and extracted key information from the top 100 most cited articles, such as the countries, institutions, authors, themes, and keywords.

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Synopsis of recent research by authors named "Chunyan Zhao"

  • - Chunyan Zhao's recent research spans multiple domains, including the assessment of UV absorbents in sunscreens and the investigation of cell division regulation in plants under drought stress, highlighting the diverse applications of environmental and health sciences.
  • - In the field of food science, Zhao explored the structural and quality characteristics of meat analogues derived from walnut protein and wheat gluten during high-moisture extrusion, suggesting potential for improving plant-based protein products.
  • - Zhao's studies also delve into medicinal applications, demonstrating the therapeutic effects of theabrownin from Pu-erh tea on gut health and assessing extraction methods for phenolic compounds to maximize antioxidant properties, indicating strong ties between food compounds and health benefits.