Publications by authors named "Chunyan Yu"

We examine peer violence trajectories among a purposive sample of urban poor adolescents over 3 years in Kinshasa, Democratic Republic of Congo (DRC); Shanghai, China, and Bandar Lampung, Denpasar, and Semarang, Indonesia. We examine peer violence experiences over time and seek to understand the relationship between gender norm perceptions and personal agency on peer violence experiences. A longitudinal (wave 1-3) panel was used from the three study sites outlined above ( = 6,660).

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Metabolic reprogramming in tumor cells plays a crucial role in promoting cell proliferation and metastasis, and is currently recognized as a significant marker of tumor progression. Interleukin-10 receptor subunit alpha (IL-10RA), a member of the type II cytokine receptor family, is predominantly expressed on macrophages and T cells and plays a crucial role in regulating immune cell metabolism and immune response. However, its role in the energy metabolic pathways of tumor cells remains unclear.

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Anxiety disorder, a prevalent mental health issue, is one of the leading causes of disability worldwide. Damage to the blood-brain barrier (BBB) is implicated in anxiety, but its regulatory mechanisms remain unclear. Herein, we show that adrenomedullin 2 (ADM2), a novel angiogenic growth factor, alleviates autistic and anxiety-like behaviors in mice.

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Background: Bladder cancer (BC) is a malignant tumor that begins in the cells of the bladder, characterized by poor cell differentiation and strong invasion capacity, with a high incidence rate. Identifying key molecules that enhance BC cells' cisplatin sensitivity can help improve the clinical efficacy of BC treatment. Hence, this study aimed to determine the expression level of long non-coding RNA (lncRNA) ADAM Metallopeptidase with Thrombospondin Type 1 Motif 9 Antisense RNA 1 () in BC and explore its related mechanism underlying the amplification of cisplatin sensitivity.

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  • The Flipped Classroom with Team-Based Learning (FC-TBL) approach has been shown to enhance academic performance and student satisfaction in molecular biology labs compared to traditional Lecture-Based Learning (LBL).
  • A study involving 109 students assessed their performance through exams and surveys, revealing positive impacts on learning outcomes not only in the lab but also in subsequent courses.
  • The results support the adoption of FC-TBL as an effective teaching model in medical education, providing both immediate and long-term benefits for students.
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Purpose: To identify the patterns of stressors associated with the COVID-19 pandemic among adolescents living in different cultural settings and to explore how adolescents cope with such stressors, particularly by type of stressor, site, and gender.

Methods: The study was based on focus group discussion data from 9 urban poor communities in Kinshasa (Democratic Republic of Congo), Blantyre (Malawi), Shanghai (China), Semarang and Denpasar (Indonesia), New Orleans (USA), Ghent (Belgium), São Paulo (Brazil), and Santiago (Chile). Translated transcripts from the focus group discussions were uploaded into ATLAS.

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  • The paper investigates how COVID-19 impacted food insufficiency among adolescents in five urban poor areas in Africa and Asia, focusing on economic and community factors.
  • The study used data from a longitudinal survey, comparing food insufficiency before and during the pandemic, and applied various statistical methods to analyze the results.
  • Findings show a significant increase in food insufficiency during COVID-19, with variations by location, gender, and socioeconomic status, highlighting the need for targeted strategies to address economic and community disparities affecting adolescents.
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Cisplatin resistance in ovarian cancer cells is mainly apoptosis resistant. Although other types of programmed cell death are highly involved in chemoresistance, which type can overcome cisplatin resistance remains unclear. The present study observed that cisplatin-sensitive SKOV3 cells and cisplatin-resistant SKOV3/DDP cells had different levels of sensitivity to sulfasalazine (SAS).

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Background: With the advancement of society, the cultivation of medical professionals equipped with solid theoretical knowledge, a strong sense of innovation, and critical thinking has become a crucial goal in the reform of medical higher education. Over recent years, the hybrid Problem-Based Learning (hPBL) model, a blend of Problem-Based Learning (PBL) and Lecture-Based Learning (LBL), has emerged as a novel approach in the medical education reform landscape of China. The application and efficacy of the hPBL model in medical experimental courses have piqued the interest of medical educators.

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  • Chronic obstructive pulmonary disease (COPD) increases the risk of lung cancer, specifically lung squamous cell carcinoma (LSCC), and may make the immune system weaker against tumors.
  • In this study, scientists looked closely at tumor samples from patients with LSCC and COPD to understand how their immune cells and tumors behave differently.
  • They found that certain immune cells in these tumors help tumors grow and escape the immune system, which could lead to worse survival, suggesting new ways to treat these cancers.
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  • Cold shock proteins (CSPs) are important in the growth and stress response of many organisms, but their role in sweet cherries is not well understood.
  • This study aimed to identify CSP genes in sweet cherry and analyze how two specific genes, PavCSP1 and PavCSP3, respond to low temperatures and salt stress.
  • The results showed that PavCSP1 and PavCSP3 are activated under these stress conditions and that yeast cells overexpressing these genes had enhanced growth when exposed to similar stressful environments.
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  • - The study investigates how different levels of basilar artery (BA) tortuosity impact blood flow in the posterior circulation of the brain, analyzing data from 138 subjects with varying tortuosity scores.
  • - Findings indicate that hypertension and vertebral artery dominance are significant risk factors for increased BA tortuosity, with a notable negative correlation between BA tortuosity and cerebral blood flow in several brain regions.
  • - The results suggest that BA tortuosity could serve as a useful biomarker for assessing posterior circulation and the severity of ischemia in that area.
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Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the world's population and has become a leading cause of chronic liver disease. In recent years, an increasing amount of data suggests that MASLD is associated with aging. As the population ages, age-related MASLD will become a major global health problem.

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The effects of adipocyte‑rich microenvironment (ARM) on chemoresistance have garnered increasing interest. Ovarian cancer (OVCA) is a representative adipocyte‑rich associated cancer. In the present study, epithelial OVCA (EOC) was used to investigate the influence of ARM on chemoresistance with the aim of identifying novel targets and developing novel strategies to reduce chemoresistance.

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Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer. Anti-PD-1/PD-L1 treatment for advanced TNBC is still limited to PD-L1-positive patients. Ataxia telangiectasia mutated (ATM) is a switch molecule for homologous recombination and repair.

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As a protein of the orphan nuclear receptor Nr4a family, Nr4a3 has no identified natural ligands. However, its biological activity can be mediated by inducing conformational changes through interactions with specific certain small molecules and receptors. Nr4a3 is activated as an early stress factor under various pathological conditions and plays a regulatory role in various tissues and cells, participating in processes such as cell differentiation, apoptosis, metabolism, and homeostasis.

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Sucrose invertase activity is positively related to osmotic and salt stress resistance in peanut. Sucrose invertases (INVs) have important functions in plant growth and response to environmental stresses. However, their biological roles in peanut are still not fully revealed.

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Microcystis blooms have a marked effect on microbial taxonomical diversity in eutrophic lakes, but their influence on the composition of microbial functional genes is still unclear. In this study, the free-living microbial functional genes (FMFG) composition was investigated in the period before Microcystis blooms (March) and during Microcystis blooms (July) using a comprehensive functional gene array (GeoChip 5.0).

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The MADS-box family, a substantial group of plant transcription factors, crucially regulates plant growth and development. Although the functions of AGL12-like subgroups have been elucidated in , rice, and walnut, their roles in grapes remain unexplored. In this study, we isolated , a member of the grape MADS-box group, and investigated its impact on plant growth and biomass production.

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Hemostatic materials are of great significance for rapid control of bleeding, especially in military trauma and traffic accidents. Chitosan (CS) hemostatic sponges have been widely concerned and studied due to their excellent biocompatibility. However, the hemostatic performance of pure chitosan sponges is poor due to the shortcoming of strong rigidity.

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  • Researchers have identified many novel RNA modifications in plants, particularly N6-methyladenosine (m6A), which play vital roles in both normal and abnormal physiological processes.
  • These RNA modifications can change the structure of RNA, affecting its ability to bind with proteins and leading to various physiological outcomes.
  • To support this research, the Plant RNA Modification Database (PRMD) was created, offering a comprehensive and user-friendly platform with tools for analysis and data visualization, accessible for free to researchers.
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Intermedin (IMD) is a member of the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily, and it is expressed extensively throughout the body. The typical receptors for IMD are complexes composed of calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein (RAMP), which leads to a biased activation towards Gα. As a diagnostic and prognostic biomarker, IMD regulates the initiation and metastasis of multiple tumors.

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  • Youth with disabilities in China have the right to sexual and reproductive health (SRH) information, but their knowledge and access to this information is often inadequate.
  • A survey of 473 unmarried youth aged 15-24 revealed that their knowledge scores related to sexual health varied significantly, with poorer knowledge observed in those with hearing and physical disabilities, particularly in rural areas.
  • The study identified school teachers as the main source of SRH information, while barriers included a lack of knowledge about where to find accurate information and feelings of embarrassment in seeking help.
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Rivers are considered as an important source of methane (CH) to the atmosphere, but our understanding for the methanogenic pathway in rivers and its linkage with CH emission is very limited. Here, we investigated the diffusive flux of CH and its stable carbon isotope signature (δC-CH) along the river-estuary continuum of the Yangtze River. The diffusive CH flux was estimated to 27.

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