CYP3A4 gene expression discloses individual differences in postoperative pain susceptibility and drug treatment response in patients with lung cancer.

This study investigates the influence of CYP3A4 gene polymorphisms on postoperative pain sensitivity and analgesic response in lung cancer patients undergoing intercostal nerve block with local anesthetics. Sixty patients (ages 31-74) undergoing thoracoscopic lung cancer surgery were enrolled and divided into two groups based on CYP3A4 gene expression level: Group I (high CYP3A4) and Group II (low CYP3A4). Postoperative pain was assessed using the Visual Analogue Scale (VAS), and patient-controlled intravenous analgesia (PCIA) pump usage, ECG ST-T segment changes, complications, hospital stay, and costs were recorded.

Status and influencing factors of nurses' burnout: A cross-sectional study during COVID-19 regular prevention and control in Jiangsu Province, China.

Background: Chinese nurses working with immense stress may have issues with burnout during COVID-19 regular prevention and control. There were a few studies investigating status of burnout and associated factors among Chinese nurses. However, the relationships remained unclear.

Clinical study of the combined use of dexmedetomidine and remifentanil in patients with coronary heart disease undergoing 3D laparoscopic surgery with EEG bispectral index monitoring.

Objective: This study sought to investigate the safety and clinical outcomes associated with the combined administration of dexmedetomidine (Dex) and remifentanil (Rem) in patients with coronary heart disease undergoing three-dimensional (3D) laparoscopic surgery, with concurrent monitoring of the electroencephalography (EEG) bispectral index.

Methods: This study is of a retrospective nature and involved a total of 60 patients with coronary heart disease who underwent 3D laparoscopic surgery at our hospital between June 2020 and September 2021. In a double-blind manner, these patients were randomly assigned to two groups: the control group (Group I), which consisted of 30 patients, and the treatment group (Group II) receiving a combination of Dex and Rem, also comprising 30 patients.

Metal-Organic-Framework-Based Nanoarrays for Oxygen Evolution Electrocatalysis.

The development of highly active and stable electrode materials for the oxygen evolution reaction (OER) is essential for the widespread application of electrochemical energy conversion systems. In recent years, various metal-organic frameworks (MOFs) with self-supporting array structures have been extensively studied because of their high porosity, abundant metal sites, and flexible and adjustable structures. This review provides an overview of the recent progress in the design, preparation, and applications of MOF-based nanoarrays for the OER, beginning with the introduction of the architectural advantages of the nanoarrays and the characteristics of MOFs.

The psychological outcomes of COVID-19 affected the pandemic-after risk perceptions of nurse clinicians: a latent profile analysis.

Background: Risk perception among nurses after the COVID-19 pandemic is a crucial factor affecting their attitudes and willingness to work in clinics. Those with poor psychological status could perceive risks sensitively as fears or threats that are discouraging. This article aimed to determine whether psychological outcomes, including post-traumatic stress disorder (PTSD), depression, anxiety, and insomnia, following the COVID-19 pandemic were differentially related to the risk perceptions of nurses working in clinics and increased perceived risk.

Quantitative study of the effects of early standardized ambulation on sleep quality in patients after hepatectomy.

Background: Sleep quality has been always an important problem for patients after hepatectomy. The main purpose of the study is to investigate the effects of early ambulation on sleep quality in patients after liver resection a quantitative study.

Methods: Patients undergoing liver tumor resection were randomly divided into two groups, and the Pittsburgh Sleep Quality Index (PSQI) was used to assess the postoperative activities and sleep quality.

Construction of cluster-based supramolecular wire and rectangle.

Reactions of [EtN][Tp*WS(CuCl)] (1) (Tp* = hydridotris(3,5-dimethylpyrazol-1-yl)borate) with 2 equiv. of AgOTf (OTf = trifluoromethanesulfonate) and 1 equiv. of several bidentate pyridine ligands including 2,5-bis(pyridine-4-yl)thiazolo[5,4-d]thiazole (L1), 2,7-di(pyridin-4-yl)-9-fluorene (L2), 2,7-di(pyridin-4-yl)-9-carbazole (L3), and 2,7-di(pyridin-4-yl)-9-fluoren-9-one (L4) afforded four W/Cu/S cluster-based supramolecular compounds [(Tp*WSCuCl)(L1)] (2), {[(Tp*WSCu)(μ-Cl)(μ-Cl)](L2)}(OTf) (3), {[(Tp*WSCu)(μ-Cl)(μ-Cl)](L3)}(OTf) (4) and {[(Tp*WSCu)(μ-Cl)(μ4-Cl)](L4)}(OTf) (5).

Heterobimetallic Cluster-Based Coordination Polymers: Assembly, Structures and Third-Order Nonlinear Optical Properties.

Reactions of (NH ) WS with CuCN, CuCN/1,2-bis(4-pyridyl)propane (bppa) or [Cu(MeCN) ]PF /bppa under different reaction conditions afforded a set of two- or three-dimensional W/Cu/S cluster-based coordination polymers including {[Et N] [WS Cu (μ-CN) (μ-I) ]} (1), [WS Cu (μ-CN) (bppa) ] (2) and {[WS Cu (bppa) ](PF ) } (3), respectively. Compound 2 can be readily formed from reaction of 1 with bppa under solvothermal conditions. Compounds 1 and 2 feature two-dimensional networks with a "sql" topology, while 3 possesses a two-fold interpenetrated three-dimensional net with a rare "reo" topology.

Nomogram for perinatal prediction of intrapartum fever: a retrospective case-control study.

Objective: To explore the risk factors for intrapartum fever and to develop a nomogram to predict the incidence of intrapartum fever.

Methods: The general demographic characteristics and perinatal factors of 696 parturients who underwent vaginal birth at the Affiliated Hospital of Xuzhou Medical University from May 2019 to April 2020 were retrospectively analysed. Data was collected from May 2019 to October 2019 on 487 pregnant women who formed a training cohort.

The Mediating Role of Perceived Social Support Between Resilience and Anxiety 1 Year After the COVID-19 Pandemic: Disparity Between High-Risk and Low-Risk Nurses in China.

One year after the Coronavirus disease 2019 (COVID-19) outbreak, China has made substantial progress in the prevention and control of the pandemic, while the epidemic situation remains grim in China since virus may easily survive with the falling temperature in winter. The present study aimed to compare the prevalence and associated factors of anxiety between high-risk and low-risk nurses 1 year after the COVID-19 outbreak, and examine the association between resilience and anxiety and its underlying mechanisms. Connor-Davidson Resilience scale, Perceived Social Support Scale and Generalized Anxiety Disorder Scale were administrated to 701 nurses from Jiangsu Province, China, 1 year after the COVID-19 outbreak.

The pattern of hospital-community-home (HCH) nursing in tracheostomy patients with severe traumatic brain injury: Is it feasible?

Background: Tracheostomy is very common in patients with severe traumatic brain injury (TBI), long-term nursing care are needed for those patients. We aimed to evaluate the effects of hospital-community-home (HCH) nursing in those patients.

Methods: This study was a before-after study design.

The solvent-induced isomerization of silver thiolate clusters with symmetry transformation.

A novel ligand-stabilized Ag12 nanocluster was synthesized as a model cluster to investigate the solvent-induced isomerization of Ag12 clusters. Another two novel Ag12 clusters as well as their related symmetry transformations were also successfully obtained through the above solvent-induced isomerization process.

In Situ Generation of Bifunctional Fe-Doped MoS Nanocanopies for Efficient Electrocatalytic Water Splitting.

Design and synthesis of non-noble metal electrocatalysts with high activity and durability for the electrolysis of water is of great significance for energy conversion and storage. In this work, we prepared a series of Fe-doped MoS nanomaterials by simple one-pot solvothermal reactions of (NH)MoS with FeCl·6HO. An optimized working electrode of Fe-MoS-5 displayed high hydrogen evolution reaction (HER) activity with a relatively small overpotential of 173 mV to achieve a current density of 10 mA cm in 0.

A hierarchically-assembled Fe-MoS/NiS/nickel foam electrocatalyst for efficient water splitting.

The development of bifunctional non-noble metal electrocatalysts demonstrating high activity and stability for the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) is of great significance for renewable and clean energy. In this work, we report hierarchically structured integrated Fe-MoS/NiS/NF (NF = nickel foam) materials prepared by a facile in situ solvothermal method, and among them, the Fe-doped MoS was assembled into spine-like nanorods. The optimized electrocatalyst (denoted as Fe-MoS/NiS/NF-2) demonstrated excellent activity and durability for performing the HER and OER in an alkaline electrolyte (pH = 14) with low overpotentials of 130.

Early enforced mobilization after liver resection: A prospective randomized controlled trial.

Objective: This randomized controlled study investigated the feasibility of early ambulation after liver resection and the effect of the amount of activity on postoperative recovery.

Methods: A total of 120 patients who underwent liver resection were randomly divided into two groups for the comparative analysis of the following factors: amount of activity, pain control, sleeping state, perioperative gastrointestinal function recovery, incidence of complications and postoperative hospital stay.

Results: Compared with the control group, patients undergoing liver resection performing early postoperative ambulation had faster gastrointestinal function recovery (First exhaust time 2.

Kinetic step-growth polymerization: A dissipative particle dynamics simulation study.

Kinetic step-growth polymerization is studied by dissipative particle dynamics coupled with our previously developed reaction algorithm on a coarse-grained level. The simulation result proves that this step-growth polymerization obeys the second-order reaction kinetics. We apply this algorithm to study the step-growth polymerization using the subunits with different flexibilities or within confinement.

[Pb(Tab)2(4,4'-bipy)](PF6)2: two-step ambient temperature quantitative solid-state synthesis, structure and dielectric properties.

Ambient temperature solid-state reaction of Pb(OAc)2 with TabHPF6 afforded an intermediate product [Pb(Tab)2]2(PF6)4, which further reacted with 4,4'-bipy in the solid state to generate a unique 2D cationic coordination polymer [Pb(Tab)2(4,4'-bipy)](PF6)2 in quantitative yield. Both complexes possess a low dielectric constant and low dielectric loss in the high electric field frequency range.

[PyH][{TpMo(μ(3)-S)4Cu3}4(μ(12)-I)]: a unique tetracubane cluster derived from the S-S bond cleavage and the iodide template effects and its enhanced NLO performances.

Reactions of [Et4N][TpMoS(S4)] with three equiv. of CuI in MeCN or in pyridine gave rise to one dicubane and one tetracubane anionic clusters, [Et4N]2[{TpMo(μ3-S)3Cu3I}2(μ-I){Cu(μ-I)2(μ4-I)2}] and [PyH][{TpMo(μ3-S)4Cu3}4(μ12-I)], and their third-order nonlinear optical (NLO) responses were greatly enhanced relative to that of the precursor.

Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-β receptor-mediated ERK and p38 pathways.

Hepatic fibrosis represents a frequent event following chronic insult to trigger wound healing reactions with accumulation of extracellular matrix (ECM) in the liver. Activation of hepatic stellate cells (HSCs) is the pivotal event during liver fibrogenesis. Compelling evidence indicates that oxidative stress is concomitant with liver fibrosis irrespective of the underlying etiology.

[Effects of acupuncture intervention on hepatic platelet-derived growth factor signaling pathway in CCl4-induced hepatic fibrosis rats].

Objective: To observe the effect of acupuncture stimulation of "Taichong" (LR 3), "Qimen" (LR 14), etc. on hepatic platelet-derived growth factor (PDGF) signal pathway activity at the protein and mRNA levels in hepatic fibrosis rats.

Methods: Forty-six SD rats were randomly divided into control (10 rats), model (12 rats), acupuncture (12 rats) and non-acupoint (12 rats) groups.

Synthesis and bioevaluation of diphyllin glycosides as novel anticancer agents.

A series of diphyllin glycosides were synthesized from diphyllin by phase transfer catalysis glycosylation, deprotection, and etherification, and the structures were established by (1) H NMR, (13) C NMR, and HRMS. These glycosides were evaluated for their in vitro cytotoxicity against HCT-116, A549, and A549T cancer cell lines by MTT assay, and most of them were cytotoxic at submicromolar concentrations. They were also effective against the paclitaxel-resistant cell line A549T.

[Inhibitory effect of acupuncture on hepatic extracellular matrix production in carbon tetrachloride-induced liver fibrosis rats].

Objective: To investigate the protective effect of acupuncture intervention on liver in carbon tetrachloride induced hepatic fibrosis rats and to reveal its impact on extracellular matrix production in the liver tissue.

Methods: A total of 46 SD rats were randomly divided into control group (n = 10), model group (n = 12), sham group (n = 12) and acupuncture group (n = 12). Hepatic fibrosis model was established by intraperitoneal injection of 50% olive oil containing CCl (1 mL/kg), 3 times in the 1st week and twice per week from the 2nd to the 6th week.

Acupuncture combined with curcumin attenuates carbon tetrachloride-induced hepatic fibrosis in rats.

Background: Increasingly, studies demonstrate the effectiveness of acupuncture therapy against liver fibrosis. Curcumin is a natural product with antifibrotic effects, but has poor pharmacokinetic profiles. This study aimed to evaluate whether acupuncture combined with curcumin could more potently attenuate liver fibrosis in chemical intoxicated rats.

Synthesis and cytotoxicity evaluation of novel podophyllotoxin derivatives.

Seven benzylamino derivatives of podophyllotoxin 8a-8g were synthesized and their chemical structures were confirmed by IR, ¹H-NMR, (13)C-NMR and ESI-MS spectral analyses. Their abilities to inhibit the growth of cancer cells A549, HCT-116 and HepG2, were investigated by MTT assay. Compound 8b possessed the highest cytotoxicity on cancer cell lines with average IC(50) values of 3.