Publications by authors named "Chunyan Lu"

Article Synopsis
  • Abnormalities in tracheal smooth muscle can lead to conditions like tracheal stenosis and tracheomalacia, but the underlying processes are not well understood.
  • The study identifies the T-type calcium channel CACNA1H as a key regulator of tracheal smooth muscle development and contraction through genetic screening in mice.
  • Reduced levels of CACNA1H are linked to congenital tracheostenosis in humans, suggesting new potential targets for treatment.
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We aimed to elucidate the relationship between and through whole-genome-based analysis. The genome-derived 16S rRNA gene sequences of KCTC 39738 and KCTC 39739 shared a 100% similarity. Phylogenetic trees based on 16S rRNA gene and whole-genome sequences revealed that KCTC 39738 and KCTC 39739 formed a robust clade, indicating a close relationship between them.

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Plant phenology, the timing of recurrent biological events, shows key and complex response to climate warming, with consequences for ecosystem functions and services. A key challenge for predicting plant phenology under future climates is to determine whether the phenological changes will persist with more intensive and long-term warming. Here, we conducted a meta-analysis of 103 experimental warming studies around the globe to investigate the responses of four phenophases - leaf-out, first flowering, last flowering, and leaf coloring.

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A novel rod-shaped bacterium, designated as strain SYSU D60015 that formed yellowish colonies was isolated from a sandy soil collected from the Kumtag Desert in Xinjiang, China. Cells were Gram-stain-negative, oxidase-positive, catalase-negative and motile with a single polar flagellum. Growth optimum occurred between 28 and 37 °C, pH 7.

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Two Gram-stain-negative, aerobic, milk-white coloured, non-motile, short rod-shaped bacteria, designated as strains SYSU D60010 and SYSU D60012, were isolated from sand samples collected from the Taklimakan Desert of Xinjiang Province in China. Both strains were positive for oxidase, catalase and nitrate reduction, but negative for amylase, HS production, hydrolysis of gelatin and cellulase. Strains SYSU D60010 and SYSU D60012 grew well at 28 °C, at pH 7 and had the same NaCl tolerance range of 0-1 % (w/v).

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Two Gram-stain-positive, aerobic, oxidase- and catalase-negative, non-motile, and short rod-shaped actinomycetes, named SYSU T00b441 and SYSU T00b490, were isolated from tidal flat sediment located in Guangdong province, PR China. The 16S rRNA gene sequence similarity, average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between SYSU T00b441 and SYSU T00b490 were 99.3, 99.

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Article Synopsis
  • The study investigates the prevalence and risk factors of osteoporotic fractures (OPF) in Chinese individuals aged 60 and older, revealing a significant OPF prevalence of 24.7% among this population.
  • The research identifies key risk factors such as advanced age, vision loss, and chronic kidney disease, while also noting that 96.8% of OPFs were vertebral fractures, specifically in the T11, T12, and L1 regions.
  • The findings highlight the urgent need for effective diagnosis and treatment strategies for OPF in the elderly, as it poses a serious threat to bone health in this demographic.
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Introduction: This study aimed to investigate the renal safety of Zoledronic Acid (ZOL) in patients with osteoporosis (OP).

Methods: A total of 1379 patients (baseline estimated glomerular filtration rate, eGFR ≥ 60 mL/min/1.73 m) with primary OP who received ZOL from January 2008 to October 2020 at our hospital were retrospectively analyzed.

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A pink-pigmented bacterium, designated as strain SYSU D00476, was isolated from sandy soil collected from the Kumtag Desert in China. Colonies were opaque, smooth and of a slight convexity with a clearly defined border. Cells were rod-shaped, Gram-stain-negative, catalase- and oxidase-positive.

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A Gram-stain-negative, aerobic, short rod-shaped, yellow bacterium, designated SYSU DXS3180, was isolated from forest soil of Danxia Mountain in PR China. Growth occurred at 15-37 °C (optimum, 28-30 °C), pH 6.0-10.

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Objective: To explore the safety and efficacy of ultrasound-guided microwave ablation (MWA) for tertiary hyperparathyroidism (THPT) in patients with renal transplantation (RT).

Methods: In total, fifteen patients with THPT after renal transplantation who underwent MWA were enrolled in the study. The pre- and post-MWA intact parathyroid hormone (iPTH), serum calcium, phosphorus, creatinine, urea nitrogen and estimated glomerular filtration rate (eGFR) values were compared.

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Two Gram-stain-negative strains, designated as SYSU D00286 and SYSU D00782, were isolated from a sand sample collected from the Kumtag Desert in Xinjiang, north-west China. Cells were aerobic, non-motile and positive for both oxidase and catalase. Growth occurred at 4-37 °C (optimum, 28-30 °C), pH 6.

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The trachea tube is the exclusive route to allow gas exchange between the external environment and the lungs. Recent studies have shown the critical role of mesenchymal cells in tracheal tubulogenesis. Improved methods for studying the dynamics of the tracheal mesenchyme development are needed to investigate the cellular and molecular mechanisms during tracheal tubulogenesis.

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Tin-lead (Sn-Pb) perovskite solar cells (PSCs) with near-ideal bandgap still lag behind the pure lead PSCs. Disordered heterojunctions caused by inhomogeneous Sn/Pb ratio in the binary perovskite film induce large recombination loss. Here, an Sn-Pb perovskite film is reported with homogeneous component and energy distribution by introducing hydrazine sulfate (HS) in Sn perovskite precursor.

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Shifts in plant phenology influence ecosystem structures and functions, yet how multiple global change drivers interact to affect phenology remains elusive. We conducted a meta-analysis of 242 published articles to assess interactions between warming (W) and other global change drivers including nitrogen addition (N), increased precipitation (IP), decreased precipitation (DP) and elevated CO (eCO ) on multiple phenophases in experimental studies. We show that leaf out and first flowering were most strongly affected by warming, while warming and decreased precipitation were the most pronounced drivers for leaf colouring.

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Article Synopsis
  • Global warming and human activities have caused regional climate instability, leading to more frequent high-temperature events that threaten eco-environmental protection and socio-economic development.
  • Analysis of monthly maximum temperatures from 1950 to 2019 revealed a significant upward trend in seasonal average maximum temperatures (AMT) across all seasons, particularly concentrated in the 1990s to early 2000s.
  • The study found varying spatial distribution trends, with AMT increasing from south to north in spring, autumn, and winter; it also identified complex correlations between AMT and atmospheric circulation factors, with significant interactions involving the Pacific, North Atlantic, and Arctic Oscillations.
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Background: Central catheter-related thrombosis (CRT) is the most common catheter-related complication in patients with end-stage renal disease (ESRD) but is often underappreciated and misdiagnosed by radiologist.

Purpose: To find the computed tomography angiography (CTA) characteristics of central CRT, then raise the diagnosis of this disorder.

Material And Methods: A total of 301 eligible patients with ESRD who experienced both chest multi-phase multidetector CTA (MDCTA) and digital subtraction angiography were enrolled in the final analysis.

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A novel orange-coloured bacterium, designated strain SYSU D00508, was isolated from a sandy soil sampled from the Kumtag Desert in China. Strain SYSU D00508 was aerobic, Gram-stain-negative, oxidase-positive, catalase-positive and non-motile. Growth occurred at 4-45°C (optimum 28-30°C), pH 6.

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Soil nutrient loss, which leads to low plant utilization, has become an urgent issue. Graphene can improve soil fertilizer-holding properties given its small size effect, strong adsorption properties, and large specific surface area. Herein, different amounts of graphene were added to soil samples to study its effect on soil nutrient retention and growth of pepper seedlings.

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Purpose Of Review: Pseudohypoparathyroidism (PHP) is a disorder caused by mutations and/or epigenetic changes at the complex GNAS locus. It is characterized by hypocalcemia, hyperphosphatemia, and an elevated parathyroid hormone concentration secondary to the resistance of target tissues to the biological actions of parathyroid hormone. PHP is divided into several subtypes with different yet overlapping phenotypes.

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An actinobacterium, designated as SYSU T00001, was isolated from a tidal flat sediment sample from Guangdong province, China. Cells were Gram-stain-positive, aerobic, motile and short rod-shaped. Colonies on marine agar 2216 were smooth, yellow-pigmented, and circular with low convexity.

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Purpose: To investigate the use of an 80-kVp tube voltage combined with a deep learning image reconstruction (DLIR) algorithm in coronary CT angiography (CCTA) for overweight patients to reduce radiation and contrast doses in comparison with the 120-kVp protocol and adaptive statistical iterative reconstruction (ASIR-V).

Methods: One hundred consecutive CCTA patients were prospectively enrolled and randomly divided into a low-dose group (n = 50) with 80-kVp, smart mA for noise index (NI) of 36 HU, contrast dose rate of 18 mgI/kg/s and DLIR and 60 % ASIR-V and a standard-dose group (n = 50) with 120-kVp, smart mA for NI of 25 HU, contrast dose rate of 32 mgI/kg/s and 60 % ASIR-V. The radiation and contrast dose, subjective image quality score, attenuation values, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were compared.

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Objective: Vitamin D and thyroid hormones have crucial roles in bone metabolism. This study aims to explore the effects of vitamin D on bone metabolism in mice with thyrotoxicosis and its mechanisms.

Methods: 12-week-old mice were randomly divided into 6 groups (6 mice/group), the control (CON) group, vitamin D (VD) group, low-dose LT4 (Low LT4) group, low-dose LT4+VD (Low LT4+VD) group, high-dose LT4 (High LT4) group, high-dose LT4+VD (High LT4+VD) group, LT4 was provided every day and vitamin D3 every other day for 12 weeks.

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Background: Transcranial direct current stimulation (tDCS) has been widely studied for treatment of patients with prolonged disorders of consciousness (PDOC). The dorsolateral prefrontal cortex (DLPFC) is a hot target for intervention, but some controversies remain.

Purpose: This review aimed to systematically investigate the therapeutic effects of DLPFC-anodal-tDCS for patients with PDOC through a meta-analysis approach.

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