Publications by authors named "Chunyan Han"

In response to the problem of poor detection ability of object detection models for small-scale targets in intelligent transportation scenarios, a fusion method is proposed to enhance the features of small-scale targets, starting from feature utilization and fusion methods. The algorithm is based on the YOLOv4 tiny framework and enhances the utilization of shallow and mid-level features on the basis of Feature Pyramid Network (FPN), improving the detection accuracy of small and medium-sized targets. In view of the problem that the background of the intelligent traffic scene image is cluttered, and there is more redundant information, the Convolutional Block Attention Module (CBAM) is used to improve the attention of the model to the traffic target.

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Background: For patients with advanced non-small cell lung cancer (NSCLC) who have received frontline immunochemotherapy, subsequent treatment options are limited. As the first dual programmed cell death-1 (PD-1)/cytotoxic T lymphocyte-associated antigen-4 bispecific antibody approved globally, cadonilimab demonstrated potential antitumor activity in advanced NSCLC patients resistant to anti-PD-1/PD-L1 antibodies.

Methods: We retrospectively collected efficacy and safety data from advanced NSCLC patients treated with cadonilimab-based regimens in later therapy lines.

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Anthocyanins, a group of flavonoids, play diverse roles in plant growth and environmental adaptation. The biosynthesis and accumulation of anthocyanin are regulated by environmental cues, such as high light. However, the precise mechanism underlying anthocyanin biosynthesis under high light conditions remains largely unclear.

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Article Synopsis
  • * A new strategy is introduced to create oxygen-deficient Ni-Mo-Fe structures in NiFe (oxy)hydroxide that improve reaction kinetics by lowering energy barriers in key steps of the HER.
  • * The enhanced catalyst, NFM-OV/NF, shows exceptional performance with low overpotentials and impressive long-term stability, making it a cost-effective option for producing hydrogen, achieving a price of $0.92 per gallon equivalent, which is below 2026 energy targets.
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Verticillium wilt (VW) caused by Verticillium dahliae (V. dahliae) is one of the most destructive diseases in cotton (Gossypium spp.).

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Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus that encodes numerous cellular homologs, including cyclin D, G protein-coupled protein, interleukin-6, and macrophage inflammatory proteins 1 and 2. KSHV vCyclin encoded by ORF72, is the homolog of cellular cyclinD2. KSHV vCyclin can regulate virus replication and cell proliferation by constitutively activating cellular cyclin-dependent kinase 6 (CDK6).

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During viral infection, the innate immune system utilizes a variety of specific intracellular sensors to detect virus-derived nucleic acids and activate a series of cellular signaling cascades that produce type I IFNs and proinflammatory cytokines and chemokines. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus that has been associated with a variety of human malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Infection with KSHV activates various DNA sensors, including cGAS, STING, IFI16, and DExD/H-box helicases.

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  • Cost-effective transition metal chalcogenides like CoSe have potential as electrocatalysts for hydrogen evolution reactions but struggle with HER kinetics and stability.
  • A new catalyst, (c/o)-CoSe-W, features a nanoflower shape and W doping, which allows a controlled phase transition that enhances its performance.
  • This catalyst achieves exceptional HER activity similar to platinum, with low overpotentials in both alkaline (29.8 mV) and acidic (35.9 mV) environments, while also demonstrating long-term durability thanks to its unique phase interfaces.
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Lung adenocarcinoma (LUAD), a prominent lung cancer subtype, has an underexplored relationship with PANoptosis, a recently discovered mode of tumour cell death. This study incorporated iron death, copper death, scorch death, necrotizing apoptosis and bisulfide death into a pan-death gene set (PANoptosis) and conducted single-cell analysis of scRNA-seq data from 11 LUAD samples. Differentially expressed genes were identified, and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed.

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The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration-time profiles in the systemic circulation, as a surrogate to the site of action. However, similarity of profiles from two formulations in the systemic circulation does not imply similarity in the gastrointestinal tract (GIT) nor local BE. We have explored the concordance of BE conclusions for a set of hypothetical formulations based on budesonide concentration profiles in various segments of gut vs.

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Article Synopsis
  • Aflibercept, used for metastatic colorectal cancer, has unclear antiangiogenesis-related side effects, prompting a systematic review of its adverse events when combined with chemotherapy.
  • The study included data from 2889 patients across 10 trials and showed notable adverse effects such as hypertension (44.2%) and proteinuria (31.3%) in single-arm studies, with higher risks noted in randomized controlled trials for hypertension and proteinuria.
  • Statistical analyses confirmed the increased incidence rates of serious adverse events in patients treated with aflibercept, highlighting the need for careful monitoring during treatment.
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In recent years, video stabilization has improved significantly in simple scenes, but is not as effective as it could be in complex scenes. In this study, we built an unsupervised video stabilization model. In order to improve the accurate distribution of key points in the full frame, a DNN-based key-point detector was introduced to generate rich key points and optimize the key points and the optical flow in the largest area of the untextured region.

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(1) Background: At present, the efficacy and safety of thoracic radiotherapy (TRT) after chemo-immunotherapy (CT-IT) in patients with extensive-stage small-cell lung cancer (ES-SCLC) still remain unclear. The purpose of this study was to evaluate the role of TRT after CT-IT in patients with ES-SCLC. (2) Methods: From January 2020 to October 2021, patients with ES-SCLC treated with first-line anti-PD-L1 antibody plus platinum-etoposide chemotherapy were enrolled retrospectively.

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Respiratory tract infections such as the ongoing coronavirus disease 2019 (COVID-19) has seriously threatened public health in the last decades. The experience of fighting against the epidemic highlights the importance of user-friendly and accessible point-of-care systems for nucleic acid (NA) detection. To realize low-cost and multiplexed point-of-care NA detection, a swing-assisted multiplexed analyzer for point-of-care respiratory tract infection testing (SMART) was proposed to detect multiple respiratory tract pathogens using visible loop-mediated isothermal amplification.

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Background: Gastric cancer (GC) is one of the most serious gastrointestinal malignancies with bad prognosis. The association between GC and cuprotosis-related genes has not been reported.

Methods: The clinical and RNA expression of patients with GC were downloaded from TCGA database.

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Non-specific binding in metabolism systems leads to an underestimation of the true intrinsic metabolic clearance of compounds being studied. Therefore binding needs to be accounted for when extrapolating data to predict the metabolic clearance of a compound. While techniques exist for experimentally determining the fraction of a compound unbound in metabolism systems, early in drug discovery programmes computational approaches are often used to estimate the binding in the system.

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Kaposi's sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with the capacity to establish life-long latent infection. During latent infection, the viral genome persists as a circular episome that associates with cellular histones and exists as a nonintegrated minichromosome in the nucleus of infected cells. Chromatin structure and epigenetic programming are required for the proper control of viral gene expression and stable maintenance of viral DNA.

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Background: Most human papillomavirus (HPV)-positive women recover from infections and do not develop cervical intraepithelial neoplasia (CIN) and cervical cancer. Additional triage approaches are needed to reduce unnecessary colposcopy referrals. The aim of this study is to determine the high-risk HPV prevalence in a hospital-based population and to evaluate the performance of p16/Ki-67 dual-stain test for the triage of high-risk HPV-positive women to detect precursor lesions and cervical cancer compared with the ThinPrep cytologic test (TCT).

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In recent years, the pedestrian detection technology of a single 2D image has been dramatically improved. When the scene becomes very crowded, the detection performance will deteriorate seriously and cannot meet the requirements of autonomous driving perception. With the introduction of the multi-view method, the task of pedestrian detection in crowded or fuzzy scenes has been significantly improved and has become a widely used method in autonomous driving.

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The avian leukosis virus (ALV) strain DL00766 was isolated from a farm in China. The phylogenetic analysis showed that env had the highest homology with the E subgroup reference strain, ranging from 94.5% to 94.

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Background: Preoperative risk evaluation systems are significant and important to the allocation of medical resources and the communication between doctors and patients. The European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) is widely used in clinical practice. Cardiac troponin T (cTnT) can specifically and accurately reflect myocardial injury.

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Atrial fibrillation (AF), known as the most common arrhythmia in the developed world, affects 1.5-2.0% of the population.

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Background: Renal dysfunction is independently associated with increased early and late mortality after coronary artery bypass graft (CABG) surgery. Off-pump CABG (OPCABG) avoids postoperative complications from the cardiopulmonary bypass, but it is unclear how it is impacted by occult renal dysfunction (ORD). This study aimed to investigate the effects of ORD on early and late outcomes after OPCABG.

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