Risk prediction model of uterine corpus endometrial carcinoma based on immune-related genes.

Background: Given the significant role of immune-related genes in uterine corpus endometrial carcinoma (UCEC) and the long-term outcomes of patients, our objective was to develop a prognostic risk prediction model using immune-related genes to improve the accuracy of UCEC prognosis prediction.

Methods: The Limma, ESTIMATE, and CIBERSORT methods were used for cluster analysis, immune score calculation, and estimation of immune cell proportions. Univariate and multivariate analyses were utilized to develop a prognostic risk model for UCEC.

Effect of storage time of paraffin sections on the expression of PD-L1 (SP142) in invasive breast cancer.

Background: PD-L1 staining using long-stored paraffin sections may not be consistent with the true PD-L1 expression of patients. Therefore, it is necessary to explore the expression of PD-L1(SP142) in paraffin sections of invasive breast cancer with different storage times and the optimal storage temperature for unstained paraffin sections.

Methods: The study included 71 cases of PD-L1(SP142) positive breast cancer.

Pomegranate plasma heterostructure regulated 1D biomass derived microtube networks for lightweight broadband microwave absorber.

The excessive aggregation of magnetic metal particles and the resulting skin effect tend to cause a serious imbalance in impedance matching, which hinders its application in aerospace and military wave absorption fields. Obviously, effective dispersion configuration and network construction are two practical measures to develop broadband lightweight absorbers. Based on the recycling theme, pomegranate plasma heterostructure regulated one-dimensional (1D) biomass derived microtube networks are achieved through the conversion and utilization of waste Platanus ball fibers.

Stachydrine Relieved the Inflammation and Promoted the Autophagy in Diabetes Retinopathy Through Activating the AMPK/SIRT1 Signaling Pathway.

Background: Diabetes retinopathy (DR) is a chronic, progressive, and potentially harmful retinal disease associated with persistent hyperglycemia. Autophagy is a lysosome-dependent degradation pathway that widely exists in eukaryotic cells, which has recently been demonstrated to participate in the DR development. Stachydrine (STA) is a water-soluble alkaloid extracted from .

Rapid diffusion of H and strong adsorption of D in Ni-4PyC realized the efficient separation of H/D by gas chromatography.

In this work, Ni-4PyC was selected as the material for the separation of hydrogen isotopes H/D, and the mechanism of hydrogen isotope H/D separation was investigated by molecular simulation. The results showed that the adsorption selectivity of Ni-4PyC for D/H increased from 1.26 to 1.

Chinese legal response to the shared motherhood model in lesbians' family-making.

Despite the non-recognition of same-sex relationships or marriage by the law, lesbian motherhood has become an emerging socio-legal issue in China. To fulfil their desires to reproduce and make a family, some Chinese lesbian couples adopt a `shared motherhood model' where one lesbian contributes an egg while her partner becomes pregnant through embryo transfer following artificial insemination with a donor's sperm. Because the shared motherhood model intentionally divides the roles of biological mother and gestational mother between lesbian couples, this has allowed legal controversies to emerge associated with the parenthood of the conceived child as well as custody, support of, and visitation of the child.

Synergistic effect of blood lipids and uric acid on periodontitis in patients with type 2 diabetes.

Objective: This study investigated the interaction of dyslipidemia and hyperuricemia on periodontitis in patients with type 2 diabetes mellitus (T2DM).

Methods: The clinical data of 220 patients with T2DM (diabetes group) treated in Tianjin Baodi Hospital from January 2019 to December 2021 were retrospectively analyzed. Another 200 healthy subjects in the same period were selected as the control group.

Hierarchical porous Co-CoO@NC hollow microspheres with capacity growth by reactivation of solid-electrolyte interface films.

Transition metal oxide (TMO)-based electrodes exhibit increased capacities, yet the mechanism behind the true cause of capacity in such materials remains unclear. Herein, hierarchical porous and hollow Co-CoO@NC spheres assembled by nanorods with refined nanoparticles and amorphous carbon have been synthesized by a two-step annealing approach. A temperature gradient-driven mechanism is revealed for the evolution of the hollow structure.

Quadrangular cone carbon-constructed effective 3D network for a lightweight and broadband microwave absorbent.

Three-dimensional carbon-based materials have attracted much attention for electromagnetic wave absorption because low-dimensional materials have failed to meet the needs of constructing effective networks with ultra-light properties due to their easy agglomeration and in-plane stacking. The 3D element of quadrangular cone carbon was innovatively applied in this work to construct interconnected networks (MFC). This material successfully overcomes the disadvantages of easy agglomeration and in-plane stacking in low-dimensional elements, allowing for more efficient construction of absorbing networks.

Checkerboard-like nickel nanoislands/defect graphene aerogel with enhanced surface plasmon resonance for superior microwave absorption.

To solve the problem of dispersion of magnetic nanoparticles in ultralight electromagnetic absorption field, checkerboard-like nickel nanoislands/defect graphene aerogel (NIDG) with enhanced surface plasmon resonance was designed and prepared through electrostatic self-assembly method. This special structure successfully overcame the aggregation phenomenon of magnetic metals and built high-density gap regions to enhance surface plasmon resonance. And the NIDG has achieved excellent electromagnetic wave absorption performance in C band.

The effect of electroacupuncture on the expression of Sirt1 and STAT3 in hippocampus and amygdala of vascular dementia rats.

Objective: Inflammation has long been considered a key factor in learning and memory impairment in patients with vascular dementia (VaD). Studies have confirmed that electroacupuncture can improve the learning and memory impairment of patients with VaD by reducing inflammation, but the specific mechanism of this effect is still unclear. The aim of this study was to explore the underlying mechanism of electroacupuncture in the treatment of VaD.

High aspect-ratio sycamore biomass microtube constructed permittivity adjustable ultralight microwave absorbent.

Excessive conductivity of carbon-based materials led to poor impedance matching, hindering their electromagnetic absorbing application in aerospace and military fields. While, one-dimensional carbon materials are more favorable to build networks, satisfying impedance matching. One-dimensional carbon materials, such as carbon fibers, carbon nanotubes, carbon microtubes, etc.

Autophagy regulates X-ray radiation-induced premature senescence through STAT3-Beclin1-p62 pathway in lung adenocarcinoma cells.

Purpose: Ionizing radiation (IR) can induce autophagy and premature senescence; however, the link between them has not been clarified. Our research has shown that X-ray irradiation induces premature senescence in lung adenocarcinoma cells, and its occurrence partially depends on the signal transducer and activator of transcription 3 (STAT3). STAT3 can bind to the promoter region of Beclin1 and regulate its expression.

Hydrogen isotope separation on nickel-containing metal-organic framework@gama-alumina-based multicomponent composite packed column: Identification of individual role of each component.

A new optimized multicomponent composite, NaCrO/NaCrO/NaCl/MOF-74(Ni)@γ-AlO (S/SS/MOF-74(Ni)@γ-AlO. NaCrO = S, NaCrO = S, NaCl = S), was prepared and used as a gas chromatography stationary phase for the separation of H and D isotopes. Under the optimal chromatographic separation conditions, the resolution of the packed column for the separation of H/D was 2.

Mass Production of Large-Sized, Nonlayered 2D Nanosheets: Their Directed Synthesis by a Rapid "Gel-Blowing" Strategy, and Applications in Li/Na Storage and Catalysis.

2D nanomaterials are well suited for energy conversion and storage because of their thickness-dependent physical and chemical properties. However, current synthetic methods for translating 2D materials from the laboratory to industry cannot integrate both advantages of liquid-phase method (i.e.

Aberrant methylation-mediated silencing of lncRNA CTC-276P9.1 is associated with malignant progression of esophageal squamous cell carcinoma.

Downregulation and aberrant hypermethylation of long non-coding RNA CTC-276P9.1 have been detected in limited tumors. However, the distribution of methylated CpG sites and biological role of CTC-276P9.

A general strategy toward graphitized carbon coating on iron oxides as advanced anodes for lithium-ion batteries.

Integration of carbon materials with benign iron oxides is blazing a trail in constructing high-performance anodes for lithium-ion batteries (LIBs). In this paper, a unique general, simple, and controllable strategy is developed toward in situ uniform coating of iron oxide nanostructures with graphitized carbon (GrC) layers. The basic synthetic procedure only involves a simple dip-coating process for the loading of Ni-containing seeds and a subsequent Ni-catalyzed chemical vapor deposition (CVD) process for the growth of GrC layers.

Template-free fabrication of graphene-wrapped mesoporous ZnMnO nanorings as anode materials for lithium-ion batteries.

We rationally designed a facile two-step approach to synthesize ZnMnO@G composite anode material for lithium-ion batteries (LIBs), involving a template-free fabrication of ZnMnO nanorings and subsequent coating of graphene sheets. Notably, it is the first time that ring-like ZnMnO nanostructure is reported. Moreover, our system has been demonstrated to be quite powerful in producing ZnMnO nanorings regardless of the types of Zn and Mn-containing metal salts reactants.

Prognostic Significance of MAGE-A11 in Esophageal Squamous Cell Carcinoma and Identification of Related Genes Based on DNA Microarray.

Background And Aims: This study aims to investigate the expression pattern of melanoma-associated antigen-A11 (MAGE-A11) in esophageal squamous cell carcinoma (ESCC) specimens and analyze its prognostic significance for ESCC patients. In addition, the purpose of our study was also to explore the biological function of MAGE-A11 in ESCC cells based on DNA microarray.

Methods: Immunohistochemistry was used to detect the expression of MAGE-A11 in ESCC specimens, and its prognostic significance was analyzed by statistical analysis.

Hierarchically constructed NiCo2S4@Ni(1-x)Co x (OH)2 core/shell nanoarrays and their application in energy storage.

We report a new type of core-shell heterostructure consisting of a rod-like NiCo2S4 (NCS) core and an urchin-like Ni(1-x)Co x (OH)2 (NCOH) shell via a simple hydrothermal route coupled with a facile electrodeposition. NCS nanorod arrays (NRAs) can not only act as excellent electrochemically active materials by themselves, but they can also serve as hierarchical porous scaffolds capable of fast electron conduction and ion diffusion for loading a large amount of additional active materials. Moreover, it is observed that the urchin-like NCOH nanosheets coating could bind the inner NCS nanorods together and thereby reinforce the whole structure mechanically.

Surrogacy litigation in China and beyond.

Chinese law neither generally prohibits nor expressly permits surrogacy. As there has been a massive underground surrogacy market in the country, surrogacy lawsuits have occurred from time to time. Chinese courts are called to decide a number of disputed issues regarding validity of surrogacy contract, parenthood of the surrogate child, and sole care and control of the surrogate child.

Involuntary detention and treatment of the mentally ill: China's 2012 Mental Health Law.

The long-awaited Mental Health Law of China was passed on 26 October 2012 and took effect on 1 May 2013. Being the first national legislation on mental health, it establishes a basic legal framework to regulate mental health practice and recognizes the fundamental rights of persons with mental disorders. This article focuses on the system of involuntary detention and treatment of the mentally ill under the new law, which is expected to prevent the so-called "Being misidentified as mentally disordered" cases in China.