[Progress of IgG4 related sino-nasal diseases].

IgG4 related disease（IgG4-RD）is a newly recognized chronic fibroinflammatory disease in recent years.It is often accompanied by the significant elevation of serum IgG4 level，but the diagnostic specificity of the elevation is not high.The diagnosis is mainly based on histopathology，which is characterized by dense IgG4 positive plasma cell infiltration，storiform fibrosis and obliteran phlebitis.