Publications by authors named "Chunxu Li"

Objective: Assess the complications, clinical outcomes, and angiographic results of endovascular treatment (EVT) for ruptured intracranial posterior circulation aneurysms in small arteries, and identify their risk factors.

Methods: We conducted a retrospective analysis of 79 patients with ruptured posterior circulation aneurysms in small arteries (the diameter of the parent artery was ≤2 mm) treated at our hospital between January 2014 and August 2023. All patients received EVT.

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Article Synopsis
  • Seven new loganin derivatives (A-G) and fourteen known compounds were extracted from the flowers of Gentiana delavayi Franch, with their structures confirmed using advanced analytical techniques.
  • Compound 7 exhibited strong inhibitory effects on the production of amyloid beta peptides (Aβ40 and Aβ42), which are associated with Alzheimer's disease, indicating its potential as a therapeutic agent.
  • Molecular docking studies showed that compound 7 interacts with the BACE1 enzyme, which plays a key role in Alzheimer's pathology, through both hydrophilic and hydrophobic interactions.
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Objective: To explore the value of applying multiple genetic testing techniques for the prenatal diagnosis of Turner syndrome fetuses with complex mosaic small supernumerary marker chromosomes (sSMC).

Methods: Chromosomal karyotypes of amniotic fluid samples from 5 030 pregnant women who had undergone amniocentesis at the Prenatal Diagnosis Center of the Third Affiliated Hospital of Zhengzhou University from January to December 2022 were retrospectively reviewed. Three fetuses with complex mosaicism fetuses (carrying 2 types of sSMC) were selected as the study subjects.

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Article Synopsis
  • - The study analyzed 194 patients treated for ruptured intracranial aneurysms, finding that 29.4% experienced complications during hospitalization, with an overall mortality rate of 11.9%.
  • - After a median follow-up of nearly 46.5 months, 81.4% of patients had favorable outcomes, while 18.5% had unfavorable results, leading to 1-year and 5-year survival rates of 89.5% and 85.4%, respectively.
  • - Key risk factors for complications included involvement of the basilar artery and use of external ventricular drainage; for unfavorable outcomes, advanced age and poor initial health status were significant predictors.
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Background: Symptomatic intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke worldwide. In patients undergoing endovascular treatment for ICAS, in-stent restenosis (ISR) is associated with ischemic stroke recurrence.

Objective: Intracranial drug-eluting self-expanding stent systems (COMETIU; Sinomed Neurovita Technology Inc.

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Gestures are a common way people communicate. Gesture-based teleoperation control systems tend to be simple to operate and suitable for most people's daily use. This paper employed a LeapMotion sensor to develop a mobile robot control system based on gesture recognition, which mainly established connections through a client/server structure.

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This article proposes a film-linked electrostatic self-assembly microfluidic chip for the first time, designed to be ready-to-use. Barrier films are used to isolate the gas/liquid path microchannels and the pre-stored reagents of the chip before use. Through the linkage design between the film materials, the motion of barrier films is linked to the structural changes inside the chip.

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Using styrene as a proxy for VOCs, a new method was developed to remove styrene gas in nitrogen atmospheres. The effect on the styrene removal efficiency was explored by varying parameters within the continuum dynamic experimental setup, such as ferrous ion concentration, hydrogen peroxide concentration, and pH values. The by-products are quantized by a TOC analyzer.

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Long-term nonunion of bone defects has always been a major problem in orthopedic treatment. Artificial bone graft materials such as Poly (lactic-co-glycolic acid)/β-tricalcium phosphate (PLGA/β-TCP) scaffolds are expected to solve this problem due to their suitable degradation rate and good osteoconductivity. However, insufficient mechanical properties, lack of osteoinductivity and infections after implanted limit its large-scale clinical application.

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Localization is a keystone for a robot to work within its environment and with other robots. There have been many methods used to solve this problem. This paper deals with the use of beacon-based localization to answer the research question: Can ultra-wideband technology be used to effectively localize a robot with sensor fusion? This paper has developed an innovative solution for creating a sensor fusion platform that uses ultra-wideband communication as a localization method to allow an environment to be perceived and inspected in three dimensions from multiple perspectives simultaneously.

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Lingze tablets has been used as a drug in the treatment of kidney deficiency-dampnes shea-stasis type benign prostatic hyperplasia (BPH) in Traditional Chinese Medicine, and it was found effective for BPH treatment. We aimed to investigate the mechanism of the Lingze tablets in the treatment of BPH through the network pharmacology and molecular docking technology. The active compounds of Lingze tablets were retrieved from the TCMSP, BATMAN-TCM and ETCM databases.

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  • The study compared the safety and long-term outcomes of two treatment methods (flow diversion and stent-assisted coiling) for large vertebrobasilar artery aneurysms in 66 patients from 2014 to 2021.
  • While both treatment methods showed similar mortality rates, the stent-assisted coiling group had a higher overall complication rate, but this difference was not statistically significant.
  • Angiographic results suggested a trend towards better occlusion rates in the stent-assisted coiling group, although both methods had comparable outcomes in terms of adequate aneurysm occlusion.
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Objective: As a chronic complication of aneurysmal subarachnoid hemorrhage(aSAH), Shunt dependent hydrocephalus (SDHC) often leads to severe neurological deficits. At present, risk factors of SDHC after aSAH are being refined. So this study aims to investigate independent risk factors and develop a novel score to identify early the patients who require a permanent shunt.

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Polylactic acid-glycolic acid (PLGA) has been widely used in bone tissue engineering due to its favorable biocompatibility and adjustable biodegradation. 3D printing technology can prepare scaffolds with rich structure and function, and is one of the best methods to obtain scaffolds for bone tissue repair. This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds.

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CSFL caused by spinal dural defect is a common complication of spinal surgery, which need repair such as suture or sealants. However, low intracranial pressure symptoms, wound infection and prolonged hospital associated with pin-hole leakage or loose seal effect were often occurred after surgical suture or sealants repair. Stable, pressure resistance and high viscosity spinal dural repair patch in wet environment without suture or sealants was highly needed.

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For conventional near-infrared spectroscopy (NIR) technology, even within the same sample, the NIR spectral signal can vary significantly with variation of spectrometers and the spectral collection environment. In order to improve the applicability and application of NIR prediction models, effective calibration transfer is essential. In this study, a stability-analysis-based feature selection algorithm (SAFS) for NIR calibration transfer is proposed, which is used to extract effective spectral band information with high stability between the master and slave instruments during the calibration transfer process.

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Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly prevalent among middle-aged and elderly people globally. The main therapy method for intervertebral disk degeneration is surgical intervention, including interbody fusion, disk replacement, and diskectomy. However, the stress changes caused by traditional fusion surgery are prone to degeneration of adjacent segments, while non-fusion surgery has problems, such as ossification of artificial intervertebral disks.

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Magnetic control systems of micro-robots have recently blossomed as one of the most thrilling areas in the field of medical treatment. For the sake of learning how to apply relevant technologies in medical services, we systematically review pioneering works published in the past and divide magnetic control systems into three categories: stationary electromagnet control systems, permanent magnet control systems and mobile electromagnet control systems. Based on this, we ulteriorly analyze and illustrate their respective strengths and weaknesses.

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Background: It is imperative to preoperatively distinguish dural ossification (DO) and thus anticipate the risks and outcome of the surgery for patients with ossification of ligamentum flavum (OLF). However, studies have disagreed as to the efficacy of the radiographic signs or factors to predict DO and surgical outcome. In additon, the association between the cerebrospinal fluid cross-section area ratio (CCAR) and DO or clinical outcome had not been reported.

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Background/objective: The reported incidence of scoliosis among adolescents in China differs according to screening method owing to the lack of uniformity and limitations of certain techniques. We aimed to design, develop, and validate a non-invasive, accurate, portable, fast, and automated tool that would enable the measurement and storage of data during scoliosis screening.

Methods: We designed a new portable electronic scoliosis screening device (PESSD)-for the identification of adolescent scoliosis based on ergonomics theory.

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Article Synopsis
  • * Research indicates that increased CO levels may lead to greater silencing of Bt genes in transgenic rice, impacting the crops' ability to produce effective defenses against pests.
  • * A study found that while N fertilization boosted biomass and protein content in Bt rice, elevated CO heightened transgene methylation (which can silence genes) and negatively affected the production of foliar Bt protein at certain N levels, suggesting a complex interaction between CO, N fertilization, and transgene expression.
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With requirements to improve life quality, smart homes, and healthcare have gradually become a future lifestyle. In particular, service robots with human behavioral sensing for private or personal use in the home have attracted a lot of research attention thanks to their advantages in relieving high labor costs and the fatigue of human assistance. In this paper, a novel force-sensing- and robotic learning algorithm-based teaching interface for robot massaging has been proposed.

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Geomagnetic field (GMF) intensity can be used by some animals to determine their position during migration. However, its role, if any, in mediating other migration-related phenotypes remains largely unknown. Here, we simulated variation in GMF intensity between two locations along the migration route of a nocturnal insect migrant, the brown planthopper , that varied by approximately 5 µT in field intensity.

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To improve sulfuric acid recovery from sodium sulfate wastewater, a lab-scale bipolar membrane electrodialysis (BMED) process was used for the treatment of simulated sodium sulfate wastewater. In order to increase the concentration of sulfuric acid (HSO) generated during the process, a certain concentration of ammonium sulfate solution was added into the feed compartment. To study the influencing factors of sulfuric acid yield, we prepared different concentrations of ammonium sulfate solution, different feed solution volumes, and different membrane configurations in this experiment.

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ZIF-8 nanoparticle-doped polyvinyl alcohol (PVA)-S-MC films were prepared via casting method. The effect of different concentrations of ZIF-8 on the physical properties and structural characterization of the films were investigated. The results indicated that ZIF-8 could increase the water resistance and mechanical property of the membrane.

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