Technol Cancer Res Treat
November 2021
Background: Human epididymis protein 4 (HE4) is a novel cancer biomarker. This study evaluates the prognostic role of HE4 in determining the survival of endometrial cancer patients.
Methods: Literature search was conducted in electronic databases (Embase, Ovid, PubMed, Scopus, and Web of Science).
Objective: To investigate the antitumor effects of Graphene oxide (GO) on tumor invasion and metastasis in human cervical cancer Hela cells.
Results: GO significantly inhibited cell viability and the number of clones, promoted cell apoptosis, as well as suppressed cell migration and invasion, and destroyed the structure of actin cytoskeleton of Hela cells in a dose-dependent manner in. Moreover, the expression of metastasis-related proteins, including MMP2 and Cdc42, were significantly suppressed by the treatment of GO.
Zhonghua Wei Chang Wai Ke Za Zhi
July 2015
Objective: To investigate the expression of TMEMl6A in the colon of intractable functional constipation patients and its clinical implications.
Methods: A total of 30 patients with intractable chronic functional constipation were selected as trial group (full thickness tissue of sigmoid colon), 30 patients with colon cancer as control group (distant tissues at least 5 cm away from cancer). Tissues from two groups were collected in our hospital from February 2012 to June 2014 and confirmed by pathological diagnosis.
Zhonghua Wei Chang Wai Ke Za Zhi
May 2015
Objective: To establish an innovative rat model of slow transit constipation by selective chemical ablation of the colon enteric plexus.
Methods: Sprague Dawley rats, 5-6 weeks old, were randomly divided into normal control group, sham operation group, treatment group I, II, III, IIII. The normal control group did not receive treatment.