Morphologic characteristics of temporomandibular joint on the patients with anterior disc displacement without osteoarthritis: a case-based research.

We investigated the effect of anterior disc displacement without osteoarthritis (ADDwoOA) on the morphology of the temporomandibular joint (TMJ) utilizing three-dimensional (3D) models of 23 asymptomatic individuals and 30 ADDwoOA patients. Statistical analyses between the groups were performed by measuring 10 morphological parameters. ADDwoOA patients showed significantly decreased levels of the sagittal ramus angle (SRA) and joint spaces compared with asymptomatic subjects.

Thermodynamic limits of humidifiers and dehumidifiers.

Humidification and dehumidification are among the most important desalination technologies, in which humidifiers and dehumidifiers are the key components. Previous research has mainly focused on overall system improvement, but few studies have focused on the thermodynamic limitations of the humidification and dehumidification processes. By introducing temperature and enthalpy effectiveness, the thermodynamic limits have been explored.

Effect of condylar rotation on the stress environment of the temporomandibular joint in patients with mandibular protrusion.

Purpose: The study aims to analyse the effects of condylar rotation on the biomechanical environment of the TMJ after bilateral sagittal split ramus osteotomy (BSSRO) through the finite element method (FEM).

Methods: Thirteen patients with mandibular prognathism and twenty-three normal subjects were recruited. The three-dimensional (3D) models were reconstructed.

Demethylzeylasteral (T-96) Alleviates Allergic Asthma via Inhibiting MAPK/ERK and NF-κB Pathway.

Introduction: Demethylzeylasteral (T-96), a new extract of Tripterygium wilfordii Hook F, exerted immunomodulatory properties in autoimmune diseases, but its effect on airway inflammatory diseases remains unclear. Our study aims to explore the protective effect and underlying mechanism of T-96 in allergic asthma.

Methods: The OVA-induced asthmatic mice were administered by gavage with T-96 (0.

A ground reaction force model of speed skating based on non-contact measurement system.

Accurate collection and analysis of ground reaction force (GRF) data are crucial for optimizing the technical movements of speed skaters; however, it has been a challenge for the limitations of experimental equipment and application scenarios. Therefore, we proposed a novel approach for estimating GRF based on kinematics obtained from markerless video tracking systems and achieved low errors compared with the experimental data. Our method allows for further biomechanical analysis, including muscle force and power, during speed skating competitions.

Molecular simulation of Rayleigh-Brillouin scattering in binary gas mixtures and extraction of the rotational relaxation numbers.

Rayleigh-Brillouin scattering (RBS) in gases has received considerable attention due to its applications in LIDAR (light detection and ranging) remote sensing and gas property measurements. In most cases, the RBS spectra in the kinetic regime are calculated based on kinetic model equations, which are difficult to be applied to complex gas mixtures. In this work, we employ two widely used molecular simulation methods, i.

Complexity Evaluation of an Environmental Control and Life-Support System Based on Directed and Undirected Structural Entropy Methods.

During manned space missions, an environmental control and life-support system (ECLSS) is employed to meet the life-supporting requirements of astronauts. The ECLSS is a type of hierarchical system, with subsystem-component-single machines, forming a complex structure. Therefore, system-level conceptual designing and performance evaluation of the ECLSS must be conducted.

The short-term safety and effectiveness of a new distal perforating stent graft in Type B aortic dissection: a retrospective study.

Background: Spinal artery ischemia (SCI) events can result from over coverage of the descending thoracic aorta with a coated stent during Thoracic Endovascular Aortic Repair (TEVAR). The aim of this study was to determine whether a new distal perforating stent could reduce the incidence of spinal cord ischemia while remodeling the true lumen.

Methods: TBAD patients treated with Talos stent in the vascular surgery Department of Yan 'an Hospital affiliated to Kunming Medical University between December 2017 and October 2019 were retrospectively analyzed to investigate the short-term safety and effectiveness of Talos stent.

Influences of Different Architectures on the Thermodynamic Performance and Network Structure of Aircraft Environmental Control System.

The environmental control system (ECS) is one of the most important systems in the aircraft used to regulate the pressure, temperature and humidity of the air in the cabin. This study investigates the influences of different architectures on the thermal performance and network structure of ECS. The refrigeration and pressurization performances of ECS with four different architectures are analyzed and compared by the endoreversible thermodynamic analysis method, and their external and internal responses have also been discussed.

Endovascular aortic repairs combined with looping-chimney technique for repairing aortic arch lesions and reconstructing left common carotid artery.

Background: The aim of this retrospective study was to evaluate the feasibility and efficacy of thoracic endovascular aortic repairs (TEVAR) combined with looping chimney technique (LCT) for repairing aortic arch lesions and reconstructing left common carotid artery.

Methods: Total of 14 patients (mean age 52.86±14.

Effects of vibration intensity on lower limb joint moments during standing.

Muscle activity and joint moment of the lower limbs can provide different information about the stimulation of controlled whole-body vibration (CWBV) on human body. Previous studies investigated the immediate effects of the intensity of CWBV on enhancing lower-limb muscle activity. However, no study has examined the possible influence of CWBV intensity on joint loading.

Celastrol reverses palmitic acid (PA)-caused TLR4-MD2 activation-dependent insulin resistance via disrupting MD2-related cellular binding to PA.

Elevated plasma statured fatty acids (FFAs) cause TLR4/MD2 activation-dependent inflammation and insulin tolerance, which account for the occurrence and development of obesity. It has been confirmed that statured palmitic acid (PA) (the most abundant FFA) could bind MD2 to cause cellular inflammation. The natural compound celastrol could improve obesity, which is suggested via inhibiting inflammation, yet the detailed mechanism for celastrol is still unclear.

Demethylzeylasteral (ZST93) inhibits cell growth and enhances cell chemosensitivity to gemcitabine in human pancreatic cancer cells via apoptotic and autophagic pathways.

The overall 5-year survival rate of patients with human pancreatic cancer remains less than 8% because of its aggressive growth, early metastasis and resistance to conventional chemoradiotherapy. It is essential to develop innovative and effective therapeutic agents to improve its prognosis. Demethylzeylasteral (ZST93) is a novel triterpenoid monomer extracted from the xylem of Tripterygium roots.

COMPARISON OF ORGAN DOSES IN HUMAN PHANTOMS: VARIATIONS DUE TO BODY SIZE AND POSTURE.

Organ dose calculations performed using human phantoms can provide estimates of astronauts' health risks due to cosmic radiation. However, the characteristics of such phantoms strongly affect the estimation precision. To investigate organ dose variations with body size and posture in human phantoms, a non-uniform rational B-spline boundary surfaces model was constructed based on cryosection images.

Inhibiting inducible miR-223 further reduces viable cells in human cancer cell lines MCF-7 and PC3 treated by celastrol.

Background: Celastrol is a novel anti-tumor agent. Ways to further enhance this effect of celastrol has attracted much research attention.

Methods And Results: Here, we report that celastrol treatment can elevate miR-223 in human breast cancer cell line MCF-7 and prostate cancer PC3.

Demethylzeylasteral (T-96) Treatment Ameliorates Mice Lupus Nephritis Accompanied by Inhibiting Activation of NF-κB Pathway.

Background: Inflammation plays a vital role in the pathogenesis in lupus nephritis (LN), which is largely attributable to the activation of nuclear factor kappa B (NF-κB) signal pathway. NF-κB up-regulates pro-inflammatory mediators, such as TNF-α, cyclo-oxygenase-2 (COX-2) and ICAM-1, and promotes macrophage infiltration into renal tissue, further inducing the progression of LN. Over the past 30 years, research has demonstrated that Tripterygium wilfordii Hook F (TWHF) possesses potent anti-inflammatory and immunosuppressive activities, and that demethylzeylasteral (T-96), an extract of TWHF, may be one of the responsible compounds.

Peptide deformylase inhibitor actinonin reduces celastrol's HSP70 induction while synergizing proliferation inhibition in tumor cells.

Background: Celastrol is a promising anti-tumor agent, yet it also elevates heat shock proteins (HSPs), especially HSP70, this effect believed to reduce its anti-tumor effects. Concurrent use of siRNA to increase celastrol's anti-tumor effects through HSP70 interference has been reported, but because siRNA technology is difficult to clinically apply, an alternative way to curb unwanted HSP70 elevation caused by celastrol treatment is worth exploring.

Methods: In this work, we explore three alternative strategies to control HSP70 elevation: (1) Searching for cancer cell types that show no HSP70 elevation in the presence of celastrol (thus recommending themselves as suitable targets); (2) Modifying HSP70-inducing chemical groups, i.

[Application of quality by design concept for the optimization of an analytical method for rhubarb anthraquinones in rat plasma].

A robust high performance liquid chromatography with fluorescence detection method (HPLC-FLD) was developed for the determination of five rhubarb anthraquinones in rat plasma using a quality by design approach. A Plackett-Burman design was utilized to screen the effects of methanol content, the pH value of mobile phase, the flow rate, column temperature, and injection volume on peak resolution, number of the theoretical plate, retention time of the last eluted peak, and tailing factor. The results showed that the methanol content in mobile phase, flow rate, and column temperature were statistically significant (p < 0.

[Effects of triptolide-medicated serum on secretion function of adrenocortical cells isolated from rats].

Objective: To study the effects of triptolide-medicated serum on secretory function of adrenocortical cells isolated from rats.

Methods: Thirty SD rats were randomly divided into control group, prednisone group, and low-, medium- and high-dose triptolide groups. Rats were administered with normal saline, prednisone and low-, medium- and high-dose triptolide respectively by gastrogavage to prepare sera containing drugs.

Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.

Celastrol, a novel HSP90 inhibitor, has recently attracted much attention due to its potential in multiple applications, such as anti-inflammation use, degenerative neuron disease relief, and tumor management. At present, the studies in celastrol's effects on HSP90's clients have focused on the kinase sub-population, while another key sub-population, nuclear transcription factors (TFs), is not being well-explored. In this study, we observe the effects of celastrol on 18 TFs (belonging to HSP90 clients) in three human cell lines: MCF-7 (breast cancer), HepG2 (hepatoma), and THP-1 (monocytic leukemia).

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way.

Background: Because some of heat shock protein 90's (HSP90) clients are key cell cycle regulators, HSP90 inhibition can affect the cell cycle. Recently, celastrol is identified both as a novel inhibitor of HSP90 and as a potential anti-tumor agent. However, this agent's effects on the cell cycle are rarely investigated.

Immunosuppressive effects of demethylzeylasteral in a rat kidney transplantation model.

In this study, we examined the immunosuppressive activity of demethylzeylasteral (T-96), isolated from the traditional Chinese herbal medicine, Tripterygium wilfordii Hook f. Its immunosuppressive effect was investigated using mouse splenocytes in vitro, and in an in vivo rat kidney transplant model. T-96 inhibited mouse splenocyte proliferation in a dose dependent manner.

Compact 10 GHz loopback arrayed-waveguide grating for high-fidelity optical arbitrary waveform generation.

We demonstrate a high-performance optical arbitrary waveform shaper based on a single 10 GHz arrayed-waveguide grating with 64 loopback waveguides and integrated amplitude and phase modulators on each waveguide. The design is compact and self-aligning and allows for bidirectional operation. The device's complex transfer function is manipulated and measured over the full 640 GHz passband.

[Tripterine inhibits all-trans retinoic acid-caused adhesion between leukemia cells and endothelial cells].

Objective: Increasing of adhesion between leukemia cells and endothelial cells during all-trans retinoic acid (ATRA) treatment plays an important role in retinoic acid syndrome. This work observed the effects of tripterine on this ATRA-caused increasing in adhesion.

Methods: The effects of tripterine on ATRA-induced expressions of adhesive molecules in acute promyelocytic leukemia cell line NB4 and human umbilical vascular endothelial cells (HUVEC) were detected by flow cytometry.