Bidirectional effects of morphine on pancreatic cancer progression via the p38/JNK pathway.

Cancer patients commonly use morphine to alleviate advanced pain. Studies have shown that morphine may influence and intervene in the malignancy of various cancers, but its role and effects on pancreatic cancer are less studied. This study aims to examine how morphine affects pancreatic cancer and its possible mechanisms.

Artesunate Inhibits the Growth of Insulinoma Cells SLC7A11/ GPX4-mediated Ferroptosis.

Background: Artesunate (ART) has been recognized to induce ferroptosis in various tumor phenotypes, including neuroendocrine tumors. We aimed to investigate the effects of ART on insulinoma and the underlying mechanisms by focusing on the process of ferroptosis.

Methods: The CCK8 and colony formation assays were conducted to assess the effectiveness of ART.

A novel two-dimensional transition metal dichalcogenide as water splitting photocatalyst with excellent performances.

With the rising demand for renewable energy, photocatalysts are considered the most promising solution to harness solar energy, and the search for photocatalysts with excellent performances remains an urgent task. Here, based on density functional theory (DFT), the photocatalytic properties of MoWS are systematically investigated. The MoWS monolayer and bilayer are demonstrated as semiconductors with indirect band gaps of 2.

Effect of Compound Fields of Ultrasonic Vibration and Applied Pressure on the 3D Microstructure and Tensile Properties of Recycled Al-Cu-Mn-Fe-Si Alloys.

The effect of compound fields of ultrasonic vibration and applied pressure (UV+AP) on three-dimensional (3D) microstructure and tensile properties of recycled Al-Cu-Mn-Fe-Si alloys was systematically studied using conventional two-dimensional (2D) microscopy, synchrotron X-ray tomography, and tensile test. The properties of UV+AP treated alloys with the pouring temperature of 740, 710 and 680 °C were compared when those alloys achieved after gravity casting. After UV+AP treatment, the alloy with pouring temperature of 710 °C show the smallest grain size.

Origin of Ferroelectricity in Epitaxial Si-Doped HfO Films.

HfO-based unconventional ferroelectric materials were recently discovered and have attracted a great deal of attention in both academia and industry. The growth of epitaxial Si-doped HfO films has opened up a route to understand the mechanism of ferroelectricity. Here, we used pulsed laser deposition to grow epitaxial Si-doped HfO films in different orientations of N-type SrTiO substrates.

Detecting the location and significance of Ezrin protein expression in hepatocellular carcinoma.

To explore the characteristics of localization and prognostic implication of Ezrin expression in HCC, 92 cases of HCC meeting strict follow-up criteria were selected for immunohistochemical staining of Ezrin protein. Correlations between Ezrin expression and clinicopathological features of HCC were evaluated using Chi-square tests, survival rates were calculated using the Kaplan-Meier method, and the relationship between prognostic factors and patient overallsurvival was analyzed using Cox proportional hazard analysis. In results, Ezrin protein was mainly expressed in the inner side of the cell membrane of the adjacent non tumor tissues, and diffusely expressed in cytoplasm of HCC tissues.