Unusual Electronic Structures of an Electron Transfer Series of [Cr(μ-η : η -N )Cr].

In dinitrogen (N ) fixation chemistry, bimetallic end-on bridging N complexes M(μ-η  : η -N )M can split N into terminal nitrides and hence attract great attention. To date, only 4d and 5d transition complexes, but none of 3d counterparts, could realize such a transformation. Likewise, complexes {[Cp*Cr(dmpe)] (μ-N )} (1-3) are incapable to cleave N , in contrast to their Mo congeners.

Snapshots of Early-Stage Quantitative N Electrophilic Functionalization.

Electrophilic functionalization of N moieties in metal dinitrogen complexes typically initiates the catalytic synthesis of N-containing molecules directly from N. Despite intensive research in the last six decades, how to efficiently and even quantitatively convert N into diazenido and hydrazido species still poses a great challenge. In this regard, systematic and comprehensive investigations to elucidate the reaction intricacies are of profound significance.

Synthesis of 3,3-Dialkyl-Substituted Isoindolinones Enabled by Nickel-Catalyzed Reductive Dicarbofunctionalization of Enamides.

Herein we report the nickel-catalyzed reductive dicarbofunctionalization of 1,1-disubstituted enamides with unactivated alkyl iodides to access the 3,3-dialkyl-substituted isoindolinone frameworks. This tandem cyclization/reductive coupling protocol exhibits broad functional group tolerance under mild conditions. The utilization of commercially accessible chiral Bn-Biox ligand allows excellent enantioselectivities to forge the tetrasubstituted stereocenters.

Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppression of Immune Response.

Purpose: Cyclophilin A (CypA) inhibits CD4 T cell signal transduction via interleukin-2-inducible T-cell kinase (Itk), a tyrosine kinase required for T helper (Th) 2 cells function. Furthermore, mice with CypA silencing developed allergic diseases associated with increased Th2 cytokines production. CD4 T cells with a Th2-cytokine pattern have been demonstrated to have a pivotal role in the pathogenesis of asthma.

[Analysis of Compatibility Laws for Acupoint Selection of Acupuncture in Treating Diabetic Gastroparasis].

Objective: To summarize and analyze the compatibility laws for acupoint selection of acupuncture in treating diabetic gastroparasis (DGP) in modern literatures of clinical researches.

Methods: Retrieved were literatures related to treating DGP by acupuncture or acupuncture combined other therapies from PubMed, CNKI, and WF from 1982 to 2014. Analyzed were frequency of acupoint use, meridians selected acupoints belonged to, regions selected, association laws of selected compatible acupoints.

[Acupoint selection: a key factor to influence the compatibility of acupoint].

In this paper, from the concept of acupoint compatibility, it is proposed that acupoint selection is a key factor to influence the compatibility of acupoint, and the nature of acupoint is closely related with the location and dominant meridian of acupoints. Acupoint selection according to the location and meridians is the basic method of acupoint compatibility, while acupoint selection based on the syndrome differentiation and the symptoms is the fundamental requirement of acupoint compatibility. Therefore, understanding the nature of acupoint, knowing the method of acupoint compatibility and selecting analogous acupoint that have identical or similar indications are the keys to improve the clinical efficacy.

Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset.

Although the beneficial effects of acupuncture in asthma treatment have been well documented, little is known regarding the biological basis of this treatment. Changes in the lung proteome of acupuncture-treated rats with asthma onset were comparatively analyzed using a two-dimensional gel electrophoresis (2DE) and mass-spectrometry- (MS-) based proteomic approach. Acupuncture on specific acupuncture points appeared to improve respiratory function and reduce the total number of leukocytes and eosinophils in bronchoalveolar lavage fluid in OVA-induced asthma onset.

Alteration of the proteome profile of the pancreas in diabetic rats induced by streptozotocin.

Type 1 diabetes mellitus (T1DM) is receiving increased attention. To obtain a better understanding of the mechanism underlying T1DM, we performed a proteomic study on a rat model induced by streptozotocin. Pancreatic proteins were separated by two-dimensional gel electrophoresis.