Cell cycle kinase CHEK2 in macrophages alleviates the inflammatory response to -induced pneumonia.

Background: Excessive macrophage-mediated inflammation participates in the development of ()-induced pneumonia. Checkpoint kinase 2 (Chek2) was screened out as macrophage-related infantile pneumonia gene after the differentially expressed analysis of RNAseq data derived from pam3CSK4 stimulated bone marrow-derived macrophages (BMDMs).

Methods: RAW264.