pH-responsive ZIF-8 nanoplatform co-loaded with DSF and ICG for multiple synergistic antitumor therapy.

Disulfiram (Allensworth et al.), an "old drug" for the treatment of chronic alcohol dependence, has received extensive attention due to its potential antitumor activity for new medical applications. However, the application of DSF in cancer therapy was limited by its extremely terrible solubility in water.