Publications by authors named "Chunwen Jia"
Background: The role of soluble interleukin-1 receptor type 2 (sIL-1R2) in acute myocardial infarction (AMI) remains undocumented. In the present study, we aimed to evaluate the possible associations of sIL-1R2 with left ventricular (LV) function, remodeling and future clinical events in the setting of AMI.
Methods: Circulating sIL-1R2 levels were quantified after percutaneous coronary intervention (PCI) on day 1 of hospital admission for 204 AMI patients, and upon enrollment of 204 healthy controls.
Backgroud The present study aimed to investigate the function and regulatory mechanisms of lncRNA KCNQ1OT1 in vascular smooth muscle cells under oxidation low lipoprotein stimulation. Methods RNA sequencing was used to detect transcriptome changes of vascular smooth muscle cells treated with oxidation low lipoprotein. KCNQ1OT1, miR-196a-5p, and FOXO1 expression levels in VSMCs after oxidation low lipoprotein treatment were assessed using qRT-PCR and western blotting.
View Article and Find Full Text PDFBackground: microRNA-mRNA axes that are involved in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) proliferation/apoptosis imbalance need to be further investigated.
Objective: To investigate the functional role of miR-183-5p/FOXO1 in VSMCs and its interaction with ox-LDL.
Methods: RNA sequencing was used to detect transcriptome changes of VSMCs treated with ox-LDL.
Article Synopsis
- A 16-year-old girl experienced syncope during a race, with significantly elevated troponin levels indicating potential heart issues, leading to a diagnosis of spontaneous coronary artery dissection (SCAD).
- Despite presenting with unusual symptoms for SCAD, the girl's condition worsened to cardiogenic shock, requiring urgent medical intervention including stenting of the left main coronary artery after confirming the diagnosis with imaging.
- The case emphasizes that SCAD should be considered in young, low-risk patients presenting with acute coronary syndrome symptoms, as timely diagnosis and treatment can lead to positive outcomes.
Background: The microRNA (miR)-mRNA axes involved in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) proliferation/apoptosis imbalance need to be investigated in more detail.
Objectives: To investigate the function and any relevant changes to miR-mRNA axes in the ox-LDL-induced proliferation/apoptosis imbalance in VSMCs.
Material And Methods: Human VSMCs were cultured and treated with ox-LDL in vitro.
[Effect of atorvastatin on ACE2 expression in pressure overload induced cardiac hypertrophy in rats].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2008
Objective: To investigate the effect of atorvastatin on the expression of angiotensin converting enzyme 2 (ACE2) mRNA and its protein in hypertrophic myocardium in rats.
Methods: Suprarenal abdominal aortic coarctation was performed to create the pressure overload induced left ventricular hypertrophy model in rats.
Results: Rats were randomly divided into 5 groups: (1) normal control group (Group A); (2) normal control group treated with atorvastatin [(5 mg/(kg.