Interstitial lung diseases associated with ANCA positivity: A different disease spectrum from interstitial pneumonia with autoimmune features.

Background: Anti-neutrophil cytoplasmic antibody (ANCA) is a type of autoantibodies associated with vasculitis. ANCA positivity is commonly observed in interstitial lung disease (ILD) patients. 7%-10% of ANCA-positive ILD patients don't present any symptoms of systemic vasculitis and are termed ANCA-positive idiopathic interstitial pneumonia (ANCA-IIP).

Synthesis and Characterization of SiO/nGO/FeO/SeQDs Nanoparticles as Potential Nanocarriers in Drug Delivery Systems.

Herein, we constructed the branch-shaped SiO/nano GO (nGO)/FeO/selenium quantum dots (QDs) (SeQDs) nanoparticles (SGF/SeQDs) embodying magnetism, fluorescence, and microwave stimulus response properties to enhance the performance of releasing drugs. The SGF/SeQDs composite was characterized by technologies including powder X-ray diffraction, transmission electron microscopy, infrared spectroscopy, etc. In the nanoparticles, the branch-shaped SiO provides a large specific surface area, nGO as the dielectric loss-style material promotes microwave-absorbing performance, and the FeO serves as a magnetic targeting agent and microwave absorber.

Spatiotemporal distribution of ecological risk of antibiotics in seven major river basins of China: An optimized multilevel assessment approach.

Antibiotics have been recognized as emerging pollutants due to their ecological and human health risks. This paper aims to enhance the ecological risk assessment (ERA) framework for antibiotics, to illustrate the distribution of these risks across different locations and seasons, and to identify the antibiotics that pose high ecological risk. This paper focuses on 52 antibiotics in seven major basins of China.

Preparation and Application of a Magnetic Oxidized Micro/Mesoporous Carbon with Efficient Adsorption for Cu(II) and Pb(II).

Water pollution is a worldwide problem that requires urgent attention and prevention and exceeding use of heavy-metal ions is one of the most harmful factors, which poses a serious threat to human health and the ecological environment. In this work, a magnetic oxidized micro/mesoporous carbon (MOMMC) was prepared for the easy separation of Cu(II) and Pb(II) from water. The dual-template method was used to prepare micro/mesoporous carbon using sucrose as the carbon source, silica nanoparticles formed by tetraethyl orthosilicate as the microporous templates, and triblock copolymer F127 as the mesoporous template.

A gut-oral microbiome-driven axis controls oropharyngeal candidiasis through retinoic acid.

A side effect of antibiotics is outgrowth of the opportunistic fungus Candida albicans in the oropharynx (oropharyngeal candidiasis, OPC). IL-17 signaling is vital for immunity to OPC, but how the microbiome impacts antifungal immunity is not well understood. Mice in standard specific pathogen-free (SPF) conditions are resistant to OPC, whereas we show that germ-free (GF) or antibiotic-treated mice are susceptible.

The toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways.

The fungal pathogen secretes the peptide toxin candidalysin, which damages epithelial cells and drives an innate inflammatory response mediated by the epidermal growth factor receptor (EGFR) and mitogen-activated protein kinase (MAPK) pathways and the transcription factor c-Fos. In cultured oral epithelial cells, candidalysin activated the MAPK p38, which resulted in heat shock protein 27 (Hsp27) activation, IL-6 release, and EGFR phosphorylation without affecting the induction of c-Fos. p38 activation was not triggered by EGFR but by two nonredundant pathways involving MAPK kinases (MKKs) and the kinase Src, which differentially controlled p38 signaling outputs.

Fungal sensing enhances neutrophil metabolic fitness by regulating antifungal Glut1 activity.

Combating fungal pathogens poses metabolic challenges for neutrophils, key innate cells in anti-Candida albicans immunity, yet how host-pathogen interactions cause remodeling of the neutrophil metabolism is unclear. We show that neutrophils mediate renal immunity to disseminated candidiasis by upregulating glucose uptake via selective expression of glucose transporter 1 (Glut1). Mechanistically, dectin-1-mediated recognition of β-glucan leads to activation of PKCδ, which triggers phosphorylation, localization, and early glucose transport by a pool of pre-formed Glut1 in neutrophils.

The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation.

Stromal cells are emerging as key drivers of autoimmunity, partially because they produce inflammatory chemokines that orchestrate inflammation. Chemokine expression is regulated transcriptionally but also through posttranscriptional mechanisms, the specific drivers of which are still incompletely defined. CCL2 (MCP1) is a multifunctional chemokine that drives myeloid cell recruitment.

Divergent functions of IL-17-family cytokines in DSS colitis: Insights from a naturally-occurring human mutation in IL-17F.

The IL-17 family is structurally distinct from other cytokine subclasses. IL-17A and IL-17F, the most closely related of this family, form homodimers and an IL-17AF heterodimer. While IL-17A and IL-17F exhibit similar activities in many settings, in others their functions are divergent.

A pyridyl-decorated Zr-organic framework for enhanced gas separation and CO transformation.

A Zr-based MOF with UiO-66 topology, which was defined as Py-UiO-66, has been synthesized by modifying the ligand of p-phthalic acid with a pyridine group. Py-UiO-66 possesses excellent chemical stability in aqueous solutions of pH = 0-13, especially when the pore structure is functionalized by hanging bare Lewis basic pyridine groups. Results of gas adsorption experiment show that Py-UiO-66 has the ability to selectively absorb CH and CO rather than CH.

Te-Vacancy-Induced Surface Collapse and Reconstruction in Antiferromagnetic Topological Insulator MnBiTe.

MnBiTe is an antiferromagnetic topological insulator that has stimulated intense interest due to its exotic quantum phenomena and promising device applications. The surface structure is a determinant factor to understand the magnetic and topological behavior of MnBiTe, yet its precise atomic structure remains elusive. Here we discovered a surface collapse and reconstruction of few-layer MnBiTe exfoliated under delicate protection.

An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F.

Oropharyngeal candidiasis (OPC) is an opportunistic infection of the oral mucosa caused by the commensal fungus IL-17R signaling is essential to prevent OPC in mice and humans, but the individual roles of its ligands, IL-17A, IL-17F, and IL-17AF, are less clear. A homozygous IL-17F deficiency in mice does not cause OPC susceptibility, whereas mice lacking IL-17A are moderately susceptible. In humans, a rare heterozygous mutation in IL-17F (IL-17F.

A Novel Gold Nanoprobe for a Simple Electrochemiluminescence Determination of a Prostate-specific Antigen Based on a Peptide Cleavage Reaction.

A novel gold nanoprobe for a sensitive and simple determination of a prostate-specific antigen (PSA) was designed on the basis of homogeneous detection and a peptide cleavage reaction. The gold nanoprobe (AuNPs-peptide-Ru1) consisted of a specific peptide tagged with a ruthenium(II) complex (Ru1) and gold nanoparticles (AuNPs) conjugated with the peptide via the strong Au-S bond between the AuNPs surface and the thiol group of the peptide. The electrochemiluminescence (ECL) enzymatic-cleavage-reaction-based bioanalytic system based on homogeneous detection has overcome shortcomings from a complicated fabrication process of traditional electrodes.

Oral epithelial cells orchestrate innate type 17 responses to through the virulence factor candidalysin.

is a dimorphic commensal fungus that causes severe oral infections in immunodeficient patients. Invasion of hyphae into oral epithelium is an essential virulence trait. Interleukin-17 (IL-17) signaling is required for both innate and adaptive immunity to During the innate response, IL-17 is produced by γδ T cells and a poorly understood population of innate-acting CD4 αβ T cell receptor (TCRαβ) cells, but only the TCRαβ cells expand during acute infection.

Unexpected Large Hole Effective Masses in SnSe Revealed by Angle-Resolved Photoemission Spectroscopy.

SnSe has emerged as an efficient thermoelectric material since a high value of the thermoelectric figure of merit (ZT) has been reported recently. Here we show with systematic angle resolved photoemission spectroscopy data that the low-lying electronic structures of undoped and hole-doped SnSe crystals exhibit noticeable temperature variation from 80 to 600 K. In particular, the hole effective masses for the two lowest lying valence band maxima are found to be very large and increase with decreasing temperature.

Bis(5-methyl-pyrazine-2-carboxyl-ato-κ²N,O)nickel(II).

In the title complex, [Ni(C₆H₅O₂N₂)₂], the Ni(II) atom is situated on an inversion centre and is coordinated in a square-planar geometry by four O atoms and two N atoms of the chelating ligands.

2-(5-Amino-2H-tetra-zol-2-yl)acetic acid.

In the title mol-ecule, C(3)H(5)N(5)O(2), the tetra-zole ring and carboxyl group form a dihedral angle of 82.25 (14)°. In the crystal, adjacent mol-ecules are linked through O-H⋯N, N-H⋯O and N-H⋯N hydrogen bonds into layers parallel to the bc plane.

A new polymorph of 5,5'-(ethane-1,2-di-yl)bis-(1H-tetra-zole).

The asymmetric unit of the title compound, C(4)H(6)N(8), contains a quarter of the mol-ecule, which possesses a crystallographically imposed centre of symmetry with all non-H atoms situated on a mirror plane. The crystal packing exhibits inter-molecular N-H⋯N hydrogen bonds and π-π stacking inter-actions between the tetra-zole rings of adjacent mol-ecules [centroid-centroid distance = 3.4402 (10) Å].

Hexaaqua-magnesium(II) bis-{5-[3-(1H-tetra-zol-5-yl)phen-yl]tetra-zolide} tetra-hydrate.

The asymmetric unit of the title compound, [Mg(H(2)O)(6)](C(8)H(5)N(8))(2)·4H(2)O, contains one half of the centrosymmetric dication, one anion and two water mol-ecules. The Mg(II) ion is coordinated by six water mol-ecules in a slightly distorted octa-hedral geometry. In the anion, the two five-membered heterocycles are twisted from the central benzene ring by 4.

Diaqua-bis-(5-methyl-pyrazine-2-carboxyl-ato-κN,O)cobalt(II) dihydrate.

In the title complex, [Co(C(6)H(5)N(2)O(2))(2)(H(2)O)(2)]·2H(2)O, the coordination geometry of the Co(2+) cation is distorted octa-hedral, with two N atoms and two O atoms from two 5-methyl-pyrazine-2-carboxyl-ate ligands in the equatorial plane. The two remaining coordination sites are occupied by two water mol-ecules. In addition, there are two uncoordinated water mol-ecules in the asymmetric unit.

catena-Poly[[dichloridonickel(II)]-μ-1,3-di-4-pyridylpropane].

The title compound, [NiCl(2)(C(13)H(14)N(2))](n), is a one-dimensional polymer built up from alternating NiCl(2) units and bridging 1,3-di-4-pyridylpropane ligands. The Ni atom has a distorted tetra-hedral coordination formed by the Cl atoms and two N atoms from two ligands. A mirror plane pases through the central methylene group of the propyl chain.