Publications by authors named "Chunrong Yi"
Article Synopsis
- The study focuses on how certain bacteria adapt to their host’s gut environment by changing their gene expression, particularly in fully colonized adult mice.
- Through the innovative use of coated-magnetic chitin beads (vcMCB), the researchers successfully extracted high-quality RNA, allowing for a detailed analysis of gene expression differences between bacteria from adult mice and those from infant models.
- The findings highlight a specific bacterial strain's ability to survive low pH and formic acid by altering its gene expression, offering new insights into the relationship between bacteria and gut microbiota, which can inform future research on other pathogenic bacteria.
Article Synopsis
- Epidemiological research shows low resistance to nitrofuran in clinical isolates, making it promising for treating multidrug-resistant bacteria, necessitating an understanding of resistance mechanisms.
- A study identified the MarR protein VnrR as key in defending against the nitrofuran derivative furazolidone (FZ), which responds to its metabolites and promotes gene activation linked to FZ degradation.
- VnrR aids in FZ metabolism through a reactive oxygen species scavenging pathway, enhancing our comprehension of antibiotic resistance and informing strategies for managing multidrug-resistant infections.
Article Synopsis
- A significant study integrated transcriptome data from both RNA-seq and microarray platforms for Vibrio cholerae, marking the first effort to combine these two types of data.
- By analyzing the integrated data, researchers identified key gene expressions and functional modules related to stress responses, gene manipulation, and metabolic pathways.
- The study also revealed novel protein interactions and highlighted similarities between clinical samples and experimental conditions, providing valuable insights into V. cholerae's pathogenic mechanisms.
Article Synopsis
- V. cholerae develops complex mechanisms to handle host stress, leading to the emergence of nonmotile mutants that enhance its colonization in mice.
- Mutations primarily occur in flagellar regulator genes like flrA, flrC, and rpoN, rather than in traditional genes related to DNA repair or scavenging systems.
- The cyclin gene dps plays a crucial role, with its deletion resulting in a significant increase in mutation rates, suggesting it influences the formation of nonmotile mutants as a strategy for better adaptation in the host environment.
Zinc finger antiviral proteins (ZAP) can significantly inhibit the replication of avian leukosis virus subgroup J (ALV-J), but the traditional method of ZAP administration is by injection, which can easily cause stress effects in chickens. In this work, we established a sodium alginate/atractylodis macrocephalae system for the encapsulation of CCCH-type zinc finger antiviral protein (CCCH-ZAP). Because of the high cost of ZAP, we first chose bovine serum albumin (BSA) as a model protein to investigate the encapsulation performance.
View Article and Find Full Text PDFSensing and resisting oxidative stress is critical for Vibrio cholerae to survive in either the aquatic environment or the gastrointestinal tract. Previous studies mainly focused on the mechanisms of oxidative stress response regulation that rely on enzymatic antioxidant systems, while functions of non-enzymatic antioxidants are rarely discussed in V. cholerae.
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