[Genetic analysis of a child with atypical Hemolytic uremic syndrome and nephrotic-range proteinuria].

Objective: To explore the clinical characteristics and genetic etiology for a child with atypical Hemolytic uremic syndrome (aHUS) in conjunct with nephrotic level proteinuria.

Methods: A child patient who had visited the Affiliated Hospital of Qingdao University on June 25, 2020 was selected as the study subject. Clinical data of the patient was collected.

Efficacy and safety of belimumab for the treatment of refractory childhood-onset systemic lupus erythematosus: A single-center, real-world, retrospective study.

Objective: This study aimed to investigate the efficacy and safety of belimumab for treating children with refractory childhood-onset systemic lupus erythematosus (cSLE).

Methods: Twenty-six cSLE patients who received belimumab treatment in our hospital from January 2020 to September 2021 (23 of them for more than 52 weeks) were enrolled in this study. Their clinical and laboratory data, assessment of disease activity, glucocorticoid dosage, and treatment-emergent adverse events (TEAEs) were retrieved for analysis.

Clinical Features and Familial Mutations in an Autosomal-Inherited Alport Syndrome Patient With the Presentation of Nephrotic Syndrome.

The aim of this study was to report the clinical features and mutations in a patient with autosomal-inherited Alport syndrome (AS). We examined the clinical data, mutation analysis results, and family tree of a patient with autosomal-inherited AS, who had nephrotic syndrome as her first manifestation. The proband was a girl of 11 months who presented with nephritic and nephrotic syndromes including gross hematuria but had a normal renal function.

Facilitating Anion Transport in Polyolefin-Based Anion Exchange Membranes via Bulky Side Chains.

Highly anion-conductive polymer electrolyte membranes with excellent alkaline stabilities for fuel cell applications were prepared. Thus, a series of polyolefin copolymers with poly(4-methyl-1-pentene) (PMP) moieties containing bulky side chains and side-chain quaternary ammonium (QA) groups were prepared through copolymerization with a Ziegler-Natta catalyst and subsequent quaternization. The separation of hydrophilic microphase and hydrophobic microphase was induced by PMP bulky side chains, and then well-connected ionic domains were formed.