Using Dual-Target rTMS, Single-Target rTMS, or Sham rTMS on Post-Stroke Cognitive Impairment.

Background: The clinical application of 10 Hz repetitive transcranil magnetic stimulation (rTMS) remains limited despite its demonstrated effectiveness in enhancing cortical excitability and improving cognitive function. The present study used a novel stimulus target [left dorsolateral prefrontal cortex + primary motor cortex] to facilitate the enhancement of cognitive function through the bidirectional promotion of cognitive and motor functions; Methods: Post-stroke cognitive impairment patients ( = 48) were randomly assigned to receive either dual-target, single-target, or sham rTMS for 4 weeks. Before and after 4 weeks of treatment, participants were asked to complete the Montreal Cognitive Assessment (MoCA) test, the Modified Barthel Index (MBI), the Trail-making Test (TMT), and the Digital Span Test (DST).

Facile Synthesis of Chromium-Doped FeMnO Nanoparticles and the Effect of Cr Content on Their Magnetic and Structural Properties.

In the present study, Fe(CrMn)O nanoparticles (0 ≤ x ≤ 0.5) were successfully synthesized by a combustion method, and the influence of Cr substitution on the structural and magnetic properties of the obtained nanoparticles was studied by various methods. The structural analysis revealed that the sample with x = 0 has a tetragonal structure, while all Cr-doped samples crystallize into a cubic structure.

Comparing conventional treatment, single-target rTMS, or dual-target rTMS for the treatment of post-stroke cognitive impairment - clinical effects and neuroscientific insights: study protocol for a randomized controlled trial.

Background: Although increasing evidence suggests that repetitive transcranial magnetic stimulation may help improve cognitive impairment after stroke, its clinical efficacy is still limited. This limitation may be due to the fact that the left dorsolateral prefrontal cortex (DLPFC) is only one of several brain areas involved in post-stroke cognitive impairment (PSCI). The aim of the present study is to reveal whether dual-target stimulation is superior to single-target stimulation and usual care in the treatment of PSCI.

Temperature-Induced Irreversible Structural Transition in FeMnO Nanoparticles Synthesized by Combustion Method.

FeMnO nanoparticles were successfully synthesized using a combustion method. The influence of the heating temperature on the evolution of the structural and magnetic properties has been studied using various methods. The structural analysis results revealed that as-synthesized nanoparticles have a tetragonal structure with an average size of ~24 nm.

Core-Shell FeO@C Nanoparticles for the Organic Dye Adsorption and Targeted Magneto-Mechanical Destruction of Ehrlich Ascites Carcinoma Cells.

The morphology, structure, and magnetic properties of FeO and FeO@C nanoparticles, as well their effectiveness for organic dye adsorption and targeted destruction of carcinoma cells, were studied. The nanoparticles exhibited a high magnetic saturation value (79.4 and 63.

Size-Dependent Magnetic and Magneto-Optical Properties of Bi-Doped Yttrium Iron Garnet Nanopowders.

Bi-doped yttrium iron garnet nanopowders were successfully synthesized by a combustion method at different synthesis conditions, and the evolution of their structural, magnetic, and magneto-optical properties has been studied by various methods. X-ray diffraction analysis revealed that crystallite size increases with increase as in annealing time (t) well as in annealing temperature (T) and varied from 15.2 nm (T = 650 °C, t = 0.

Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA.

DNA-encoded library (DEL) technology is a powerful tool for small molecule identification in drug discovery, yet the reported DEL selection strategies were applied primarily on protein targets in either purified form or in cellular context. To expand the application of this technology, we employed DEL selection on an RNA target HIV-1 TAR (trans-acting responsive region), but found that the majority of signals were resulted from false positive DNA-RNA binding. We thus developed an optimized selection strategy utilizing RNA patches and competitive elution to minimize unwanted DNA binding, followed by k-mer analysis and motif search to differentiate false positive signal.

Carbon Double Coated FeO@C@C Nanoparticles: Morphology Features, Magnetic Properties, Dye Adsorption.

This work is devoted to the study of magnetic FeO nanoparticles doubly coated with carbon. First, FeO@C nanoparticles were synthesized by thermal decomposition. Then these synthesized nanoparticles, 20-30 nm in size were processed in a solution of glucose at 200 °C during 12 h, which led to an unexpected phenomenon-the nanoparticles self-assembled into large conglomerates of a regular shape of about 300 nm in size.

Preparation and Magnetic Properties of Cobalt-Doped FeMnO Spinel Nanoparticles.

Mixed-metal oxide nanoparticles have attracted great scientific interest since they find applications in many fields. However, the synthesis of size-controlled and composition-tuned mixed-metal oxide nanoparticles is a great challenge that complicates their study for practical application. In this study, Co-doped FeMnO nanoparticles were synthesized by the solvothermal method in which the crystallization was carried out under autogenous pressure at temperatures of 190 °C for 24 h.

Amino-Functionalized FeO@SiO Core-Shell Magnetic Nanoparticles for Dye Adsorption.

FeO@SiO core-shell nanoparticles (NPs) were synthesized with the co-precipitation method and functionalized with NH amino-groups. The nanoparticles were characterized by X-ray, FT-IR spectroscopy, transmission electron microscopy, selected area electron diffraction, and vibrating sample magnetometry. The magnetic core of all the nanoparticles was shown to be nanocrystalline with the crystal parameters corresponding only to the FeO phase covered with a homogeneous amorphous silica (SiO) shell of about 6 nm in thickness.

Synthesis of FeS Nanoparticles with Various Superstructures by a Simple Thermal Decomposition Route and Their Magnetic Properties.

Pyrrhotite nanoparticles with 5C and 3C superstructures were synthesized via a simple one-step thermal decomposition method in which hexadecylamine was used as a solvent at various reaction temperatures (T). Structural analysis showed that at T = 360 °C, almost uniform in size and shape FeS nanoparticles with 3C superstructure are formed, and an increase in the reaction temperature leads to the formation of FeS nanoparticles (5C superstructure), herewith a significant increase in the size of nanoparticles is observed. High-temperature magnetic measurements in 5 repeated heating-cooling cycles revealed that after the first heating branch in the FeS samples, the λ-Peak transition disappears, and the magnetization has a Weiss-type behavior characteristic of the FeS sample.

USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury.

Hypoxia-induced apoptosis is linked to the pathogenesis of myocardial infarction (MI) and heart failure. Ubiquitin-specific peptidase 7 (USP7) is related to catabolic/pro-apoptotic signaling. However, its role in cardiomyocyte injury is unclear.

Magnetic and Magneto-Optical Oroperties of Iron Oxides Nanoparticles Synthesized under Atmospheric Pressure.

Magnetite nanoparticles were synthesized by a simple thermal decomposition process, involving only iron (III) nitrate nonahydrate as a precursor, and hexadecylamine as a solvent and stabilizer at reaction temperatures varied from 200 to 380 °C. The results of the structural analysis showed that the average crystallite size depends on the reaction temperature and increases from 4.8 to 13.

Usefulness of bevacizumab-induced hypertension in patients with metastatic colorectal cancer: an updated meta-analysis.

We tested the hypothesis that bevacizumab-induced hypertension may be a useful predictor for objective response rate, progression-free and overall survival in patients with metastatic colorectal cancer via a comprehensive meta-analysis. Search process, article selection and data extraction were independently performed by two investigators. Statistical analyses were conducted using the STATA/SE software.

Impact of allergen immunotherapy in allergic asthma.

Although traditional pharmacological approaches improve outcomes in disease management for allergic asthma, these fail to modify the underlying immune responses. Allergen immunotherapy remains the only etiological therapy for the treatment of respiratory allergies for which clinical efficacy has been demonstrated through several well-controlled studies. In this review, we examine evidence from the past 5 years regarding the impact of allergen immunotherapy on allergic asthma to inform practitioners and stimulate further discussion and research.

Increasing Prevalence of Nontuberculous Mycobacteria in Respiratory Specimens from US-Affiliated Pacific Island Jurisdictions.

Nontuberculous mycobacteria (NTM) respiratory infections represent a growing public health problem in many countries. However, there are limited published epidemiologic studies for the Western Pacific region. We reviewed respiratory specimens submitted to Diagnostic Laboratory Services in Hawaii, USA, for culture of Mycobacterium tuberculosis during August 2007-December 2011 to determine the NTM isolation rate.

Structural, Magnetic, and Electronic Properties of Mixed Spinel NiFeCrO Nanoparticles Synthesized by Chemical Combustion.

A series of nickel-chromium-ferrite NiFeCrO (with x = 1.25) nanoparticles (NPs) with a cubic spinel structure and with size d ranging from 1.6 to 47.

Combining anti-IgE with oral immunotherapy.

Food allergy is a significant medical problem that affects up to 8% of children in developed countries. At present, there are no curative therapies available in routine practice and management of food allergy involves strict allergen avoidance, education, and prompt treatment upon accidental exposure. Oral immunotherapy (OIT) is an efficacious experimental approach to food allergy and has been shown to provide a substantial benefit in terms of allergen desensitization.

Replication of a genome-wide association study on essential hypertension in Mongolians.

Replication of genome-wide significant association SNPs in independent populations is an essential approach for identifying gene-disease relationships. Therefore, we sought to investigate the top 21 SNPs (rs10507454, rs11897156, rs11897991, rs12325203, rs12541835, rs13395322, rs1525035, rs16936892, rs17010027, rs17045859, rs17136827, rs1866525, rs2045590, rs4547758, rs4655688, rs7107438, rs761353, rs8127139, rs9312305, rs9407874 and rs9865108) from a genome-wide association study of essential hypertension in Mongolians. This was a community-based case-control study involving 428 hypertensives and 638 normotensives from Kerqinzuoyihou Banner,Tongliao, Inner Mongolian Autonomous Region, China.

Structural, magnetic and electronic properties of Fe1+xGa2-xO4 nanoparticles synthesized by the combustion method.

The combustion method was used to prepare a precursor powder of an iron-gallium oxide compound which was further heat-treated in order to obtain a set of Fe1+xGa2-xO4 nanoparticles. All samples have a cubic spinel-type structure (space group Fd3[combining macron]m) and the particle size varies from 1.8 to 28.

Novel N-Substituted 2-(2-(Adamantan-1-yl)-1H-Indol-3-yl)-2-Oxoacetamide Derivatives: Synthesis and Biological Evaluation.

In this study, a series of novel N-substituted 2-(2-(adamantan-1-yl)-1H-indol-3-yl)-2-oxoacetamide derivatives were synthesized, and evaluated for their cytotoxicity in human cell lines including Hela (cervical cancer), MCF7 (breast cancer ) and HepG2 (liver cancer). Several compounds were found to have potent anti-proliferative activity against those human cancer cell lines and compound 5r showed the most potent biological activity against HepG2 cells with an IC50 value of 10.56 ± 1.

Synthesis and magnetic properties of the chromium-doped iron sulfide Fe1-xCrxS single crystalline nanoplates with a NiAs crystal structure.

Single crystalline iron sulfide nanoparticles doped with chromium Fe1-xCrxS (0 ≤x≤ 0.15) have been successfully prepared by a thermal decomposition method. The particles are self-organized into the single crystalline plates with the accurate hexagonal shape and dimensions up to 1 μ in plane and about 30-40 nm in thickness.

Structural, magnetic, and electronic properties of iron selenide Fe6-7Se8 nanoparticles obtained by thermal decomposition in high-temperature organic solvents.

Iron selenide nanoparticles with the NiAs-like crystal structure were synthesized by thermal decomposition of iron chloride and selenium powder in a high-temperature organic solvent. Depending on the time of the compound processing at 340 °C, the nanocrystals with monoclinic (M)-Fe3Se4 or hexagonal (H)-Fe7Se8 structures as well as a mixture of these two phases can be obtained. The magnetic behavior of the monoclinic and hexagonal phases is very different.

The effects of extended release niacin on lipoprotein sub-particle concentrations in HIV-infected patients.

With the advent of highly active antiretroviral therapy (HAART), Cardiovascular Disease (CVD) has emerged as the leading cause of death in Human Immunodeficiency Virus (HIV) infected patients. An atherogenic lipoprotein phenotype has been described in HIV- infected patients with a predominance of small, low density lipoprotein (SLDL) particles with accompanying elevated triglycerides and reduced high density lipoprotein cholesterol. This randomized controlled pilot study was conducted to evaluate the efficacy of Extended Release Niacin (ERN) in improving the lipid profile in HIV patients.

Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo.

Elevated levels of β-amyloid (Aβ) in the brains being a hallmark of Alzheimer's disease have been believed to play a critical role in the cognitive dysfunction that occurs in Alzheimer's disease. Recent evidence suggests that Aβ induces neuronal apoptosis in the brain and in primary neuronal cultures. In this study, we investigated the effects of puerarin, a phytoestrogen isolated from Pueraria lobata, on cognitive function and neuronal apoptosis in the intrahippocampal injection of Aβ rats and its mechanism of action.