Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation, Migration, and Invasion in Pituitary Adenomas.

Objective: Tissue inhibitors of matrix metalloproteinases () are prognostic markers in cancers. However, the role of in DNA methylation during invasive pituitary adenoma (PA) remains unclear. The purpose of this study was to assess the effects of TIMP2 and TIMP3 promoter demethylation on the proliferation, migration, and invasion of invasive PA cells.

Freeze-casting production of thermal insulating and fire-retardant lightweight aerogels based on nanocellulose and boron nitride.

Cellulose aerogels exhibit biocompatibility and biodegradability, rendering them promising candidate for application in building energy conservation and insulation materials. However, the intrinsic inflammability of pristine cellulose aerogel causes unneglectable safety concerns, hindering their application in energy-efficient buildings. Herein, a thermal insulating, fire-retardant, strong, and lightweight aerogel was produced via freeze-casting suspensions of cellulose nanofibril (CNF) and l-glutamine functionalized boron nitride nanosheets (BNNS-g).

A meta-analysis of the lymphatic microvessel density and survival in gastric cancer with 1809 cases.

Lymph node metastasis commonly occurs in gastric cancer. Previous studies have demonstrated that the overexpression of lymphatic microvessel density (LVD) is correlated with various malignancies. To evaluate the potential role of LVD in various malignancies, we conducted a systematic review and meta-analysis to thoroughly investigate the association of LVD expression with tumor progression and survival in gastric cancer.

Lower expressed miR-198 and its potential targets in hepatocellular carcinoma: a clinicopathological and in silico study.

Purpose: To investigate the clinicopathological value and potential roles of microRNA-198 (miR-198) in hepatocellular carcinoma (HCC).

Methods: Ninety-five formalin-fixed paraffin-embedded HCC and the para-cancerous liver tissues were gathered. Real-time reverse transcription quantitative polymerase chain reaction was applied to determine the miR-198 expression.