Publications by authors named "Chunqiao Lin"
Article Synopsis
- Early life stress negatively impacts gut microbiota and heightens the risk of neuropsychiatric disorders such as anxiety and social deficits.
- Research on maternally separated (MS) mice reveals that lower levels of amino acid transporters lead to decreased glutamine levels, which disrupts synaptic function in the brain's medial prefrontal cortex.
- Supplementing with certain gut commensal bacteria can improve neurobehavioral issues in MS mice by enhancing amino acid transport and restoring synaptic transmission.
Article Synopsis
- Obesity contributes to cognitive dysfunction, and the glymphatic system (GS) is crucial for understanding how it affects brain health; the study focuses on the effects of Alisma orientale on obesity-related brain impairments.
- The research investigates the ethanol extracts of Alisma orientale (EEAO) in obese mice, studying its impact on glucose/lipid metabolism, cerebral blood flow, blood-brain barrier integrity, and signs of neuroinflammation.
- Results show that EEAO reduces body weight and lipid accumulation, improves blood flow and barrier integrity, decreases inflammation markers, and effectively restores glymphatic function, ultimately improving cognitive deficits in obese mice.
Maternal immune activation (MIA) resulting from viral infections during pregnancy is linked to increased rates of neurodevelopmental disorders in offspring. However, the mechanisms underlying MIA-induced neurobehavioral abnormalities remain unclear. Here, we used a poly (I:C)-induced MIA mouse model to demonstrate the presence of multiple behavioral deficits in male offspring.
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