Publications by authors named "Chunna Yadav"

Inhaled therapy of tuberculosis (TB) by a Dry Powder Inhalation (DPI) comprising mycobacteriophage D29 and TM4 was non-inferior to oral anti-tuberculosis therapy (ATT) with isoniazid and rifampicin in a mouse model of infection with Mycobacterium tuberculosis (Mtb). No pharmaceutical phage product of mycobacteriophages is approved for large-scale production. We scaled up preparation and downstream processing of phages, developed DPI formulations, and established methods for determining identity, purity, assay, stability, and critical quality attributes (CQA).

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We prepared three variants of nintedanib dry powder inhalations (DPIs), one with dibasic calcium phosphate dihydrate (CaHPO·2HO) and two with lactose monohydrate as the carrier. CaHPO is not reported as a DPI excipient. We compared nintedanib pharmacokinetics and efficacy of the CaHPO formulation against bleomycin-induced pulmonary fibrosis following oral (3.

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