Mediating role of exercise in the relationship between body dissatisfaction and overeating using structural equation modeling.

Background: With the rapid development of society, teenagers have more access to individuals with perfect bodies and are becoming more concerned about their body image. Currently, few studies assess body image and eating disorders comprehensively in China. Given the seriousness of these issues, there is an urgent need to understand the current state of body image and eating behaviors among Chinese people and formulate preventive strategies.

Effects of physical activity on sleep quality among university students: chain mediation between rumination and depression levels.

Background: Colleges and universities are currently facing the major public health issue of poor sleep quality. Sleep quality must be taken seriously to maintain the students' emotional and physical well-being. Thus, this study sought to determine how university students' levels of physical activity related to the quality of their sleep, as well as to explore the mechanisms via which physical activity affects sleep and provide suggestions for improving it.

The effect of grandparental care on social networking sites addiction in college: mediated by social anxiety and loneliness.

Objective: Grandparental care has become a common phenomenon, yet there is still limited research on the long-term psychological effects on children raised by their grandparents. This study aims to explore the impact of early grandparental care experiences on university students' social networking sites addiction, social anxiety, and loneliness.

Methods: A random cluster sampling method was employed to select college students from a medical school in Jiangxi for a questionnaire survey.

Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K CD8 T cell activation in lupus kidney.

Objectives: B and T cells constitute the majority of infiltrating lymphocytes in the kidney and represent the local perpetrators in lupus nephritis (LN), but the underlying pathogenic mechanisms are not well elucidated. The aim of this study is to explore the kidney-specific adaptive immune landscape in patients with active LN at the single-cell level.

Methods: We performed single-cell RNA/B cell receptor (BCR)/T cell receptor (TCR) sequencing analysis on sorting-purified B and T cells from the kidney and paired peripheral blood of patients with active LN, and the periphery of matched controls.

Developmental Morphology, Physiology, and Molecular Basis of the Pentagram Fruit of .

, a key tropical and subtropical economic tree in the Oxalidaceae family, is distinguished by its unique pentagram-shaped fruit. This study investigates the developmental processes shaping the polarity of fruit and their underlying hormonal and genetic mechanisms. By analyzing the Y1, Y2, and Y3 developmental stages-defined by the fruit diameters of 3-4 mm, 4-6 mm, and 6-12 mm, respectively-we observed that both cell number and cell size contribute to fruit development.

Analysis of risk factors for postoperative anxiety and depression in endometriosis patients with reproductive intention.

Background: The occurrence of postoperative depression and anxiety in patients with endometriosis (EMS) not only causes psychological distress, but may also harm their physical health.

Aim: To explore the postoperative depression status, and its influencing factors, of EMS patients with reproductive intention.

Methods: A total of 321 EMS patients with reproductive intent were included.

Therapeutic effect and mechanism of Ento-PB on ulcerative colitis in BALB/c mice induced by sodium dextran sulfate.

The traditional Chinese medicine (TCM) formula Ento-PB containing (Linnaeus) (Blattidae) and Hand.-Mazz. (Compositae) has great potential for treating inflammation.

Prediction of glypican-3 expression in hepatocellular carcinoma using multisequence magnetic resonance imaging-based histology nomograms.

Background: Hepatocellular carcinoma (HCC) is often associated with the overexpression of multiple proteins and genes. For instance, patients with HCC and a high expression of the glypican-3 () gene have a poor prognosis, and noninvasive assessment of expression before surgery is helpful for clinical decision-making. Therefore, our primary aim in this study was to develop and validate multisequence magnetic resonance imaging (MRI) radiomics nomograms for predicting the expression of in individuals diagnosed with HCC.

The protective effects of repetitive transcranial magnetic stimulation with different high frequencies on motor functions in MPTP/probenecid induced Parkinsonism mouse models.

Background: High-frequency repeated transcranial magnetic stimulation (rTMS) stimulating the primary motor cortex (M1) is an alternative, adjunctive therapy for improving the motor symptoms of Parkinson's disease (PD). However, whether the high frequency of rTMS positively correlates to the improvement of motor symptoms of PD is still undecided. By controlling for other parameters, a disease animal model may be useful to compare the neuroprotective effects of different high frequencies of rTMS.

Interconnected Periodic Macroporous NaNbO for High-Efficiency Solar-Driven Photocatalytic Hydrogen Evolution.

Highly ordered periodic macroporous structures have been extensively utilized to significantly enhance the photocatalytic activity. However, constructing 3D interconnected ordered porous ternary nanostructures with highly crystalline frameworks remains a formidable challenge. Here, we introduce the design and fabrication of 3D interconnected periodic macroporous NaNbO (PM NaNbO) to effectively increase the density of surface-active sites and optimize the photogenerated carrier-transfer efficiency.

Gel Properties and Protein Structures of Minced Pork Prepared with κ-Carrageenan and Non-Meat Proteins.

Problems with minced pork include water release and low gel strength. This study aimed to investigate the effect of treatments with κ-carrageenan (κ-CAR), egg white powder (EWP), wheat gluten (WG), soy isolate protein (SPI), and a combination of these treatments on the gel properties and protein structures of minced pork. The cooking loss and trapped water within minced pork increased when additives were incorporated; in particular, the SPI group reached 1.

Synthesis of Spiro Polycyclic N-Heterocycles and Indolecarbazoles via Merging Oxidative Coupling and Cascade Palladium-Catalyzed Intramolecular Oxidative Cyclization.

We report a step-economic strategy for the direct synthesis of spiro polycyclic N-heterocycles and indolecarbazole-fused naphthoquinones by merging oxidative coupling and cascade palladium-catalyzed intramolecular oxidative cyclization. In the protocol, bi-indolylnaphthoquinones were first synthesized by oxidative coupling of indoles and naphthoquinones. Subsequent cascade palladium-catalyzed intramolecular oxidative cyclization of bi-indolylnaphthoquinones gave spiro polycyclic N-heterocycles and indolecarbazoles.

Effectiveness analysis of three-drug combination therapies for refractory focal epilepsy.

Selecting appropriate antiseizure medications (ASMs) for combination therapy in patients with drug-resistant epilepsy (DRE) is a complex task that requires an empirical approach, especially in patients receiving polytherapy. We aimed to analyze the effectiveness of various three-drug combinations in a group of patients with DRE under real-world conditions. This single-center, longitudinal observational study investigated patients with drug-resistant focal epilepsy who received three-drug regimens in the outpatient clinic of Tongji Hospital from September 2019 to December 2022.

Prevalence of depressive tendencies among college students and the influence of attributional styles on depressive tendencies in the post-pandemic era.

Introduction: Depression symptoms are prevalent globally, including China, with a notable impact on college students. This study aims to not only estimate the prevalence of depressive tendencies and attributional styles among college students in the post-pandemic era but also explore the relationship between the two factors. The findings of this study can provide new insights into early intervention and support services for individuals exhibiting tendencies toward depression.

Understanding the use intention and influencing factors of telerehabilitation in people with rehabilitation needs: a cross-sectional survey.

Objective: This study aimed to investigate the use intention and influencing factors of telerehabilitation in people with rehabilitation needs.

Methods: This cross-sectional survey recruited a total of 183 participants with rehabilitation needs from May 2022 to December 2022. Sociodemographic and medical data were collected by a structured questionnaire.

Single-Cell Profiling of Bone Marrow B Cells and Early B Cell Developmental Disorders Associated With Systemic Lupus Erythematosus.

Objective: The peripheral B cell compartment is heavily disturbed in systemic lupus erythematosus (SLE), but whether B cells develop aberrantly in the bone marrow (BM) is largely unknown.

Methods: We performed single-cell RNA/B cell receptor (BCR) sequencing and immune profiling of BM B cells and classified patients with SLE into two groups: early B cell (Pro-B and Pre-B) normal (EB) and EB defective/low (EB) groups.

Results: The SLE-EB group exhibited more severe disease activity and proinflammatory status, overaction of type I interferon signaling and metabolic pathways within the B cell compartment, and aberrant BCR repertoires compared with the SLE-EB group.

Identification and Characterization of CD8 CD27 CXCR3 T Cell Dysregulation and Progression-Associated Biomarkers in Systemic Lupus Erythematosus.

Systemic Lupus Erythematosus (SLE) etiopathogenesis highlights the contributions of overproduction of CD4 T cells and loss of immune tolerance. However, the involvement of CD8 T cells in SLE pathology and disease progression remains unclear. Here, the comprehensive immune cell dysregulation in total 263 clinical peripheral blood samples composed of active SLE (aSLE), remission SLE (rSLE) and healthy controls (HCs) is investigated via mass cytometry, flow cytometry and single-cell RNA sequencing.

Prevalence of Hypertension and Associated Factors among Residents Aged ≥18 Years in Ganzhou, China: A Cross-Sectional Study.

Background: Reliable epidemiologic data on the present burden of hypertension are needed in developing region-specific strategies since previous studies have suggested that China is lagging in risk factor management.

Objective: The study aimed at exploring the prevalence of hypertension and its associated factors among adult residents in Ganzhou, China. .

Causal Paradigm Between Common Comorbidities of Cardiovascular and Metabolism-Related Diseases in Elderly: Evidence from Cross-Sectional and Mendelian Randomization Studies.

Background: Comorbidity is a common problem among elderly people, significantly damaging individuals' health and healthcare systems. However, observational studies may be susceptible to residual confounding factors and bias. The present study aimed to assess the causal effect of common chronic disease comorbidity using the Mendelian randomization (MR) approach.

DZ2002 alleviates corneal angiogenesis and inflammation in rodent models of dry eye disease via regulating STAT3-PI3K-Akt-NF-κB pathway.

Dry eye disease (DED) is a prevalent ocular disorder with a multifactorial etiology. The pre-angiogenic and pre-inflammatory milieu of the ocular surface plays a critical role in its pathogenesis. DZ2002 is a reversible type III S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor, which has shown excellent anti-inflammatory and immunosuppressive activities in vivo and in vitro.