A retrospective study of estrogen in the pretreatment for medical management of early pregnancy loss and the inference from intrauterine adhesion.

Background: Estrogen has been usually used in clinic for medical pretreatment of early pregnancy loss. There was little reported the effect of estrogen combined with prostaglandin analogs in the medical management of early pregnancy loss. This retrospective study aimed to evaluate the efficacy of estrogen pretreatment for medical management of early pregnancy loss and explore the confounding factor of intrauterine adhesion (IUA) on the outcome of medical management.

Dermoscopic Image Classification of Pigmented Nevus under Deep Learning and the Correlation with Pathological Features.

The objective of this study was to explore the image classification and case characteristics of pigmented nevus (PN) diagnosed by dermoscopy under deep learning. 268 patients were included as the research objects and they were randomly divided into observation group ( = 134) and control group ( = 134). Image recognition algorithm was used for feature extraction, segmentation, and classification of dermoscopic images, and the image recognition and classification algorithm were studied as the performance and accuracy of fusion classifier were compared.

Hysteroscopic treatment and reproductive outcomes in cesarean scar pregnancy: experience at a single institution.

Objective: To study the risk factors leading to type II/III cesarean scar pregnancy and evaluate the efficacy of hysteroscopic treatment and subsequent reproductive outcomes.

Design: Retrospective study from 2013 to 2018.

Setting: Inpatient samples.

Relationship of macrophage migration inhibitory factor levels in PBMCs, lesional skin and serum with disease severity and activity in vitiligo vulgaris.

Melanocyte loss in vitiligo vulgaris is believed to be an autoimmune process. Macrophage migration inhibitory factor (MIF) is involved in many autoimmune skin diseases. We determined the possible role of MIF in the pathogenesis of vitiligo vulgaris, and describe the relationship between MIF expressions and disease severity and activity.

Application of a new intense pulsed light device in the treatment of photoaging skin in Asian patients.

Background: Intense pulsed light (IPL) technology has long been used in the treatment of photoaging skin.

Objective: To evaluate the efficacy and safety of a new IPL device in the treatment of photoaging skin in Asian patients.

Methods: One hundred fifty-two Chinese women with photoaging skin were enrolled in this open-labeled study.

Upper rim allyl- and arylazo-coupled calix[4]arenes as highly sensitive chromogenic sensors for Hg2+ ion.

The syntheses and chromogenic properties of calix[4]arenes, carrying 5,17-bisallyl-11,23-bis(p-X-phenyl)azo 3a-c, 5,11,17-triallyl-23-(p-X-phenyl)azo 4a-c, and 5,17-bis(hydroxypropyl)-11,23-bis(p-X-phenyl)azo groups on the upper rims 5a,b, are described. Unexpectedly, UV/vis spectra of the very popular 4-(4-nitrophenyl)azophenol-coupled calix[4]arenes 3c and 4c did not show any shift in lambda(max) when 10 different metal perchlorates were added separately to the host in a methanol-chloroform (v/v = 1/399) cosolvent. In contrast, the absorption spectra of calix[4]arenes with either 4-methoxyphenylazo (3b-5b) or 4-phenylazo (3a-5a) on the upper rim showed substantial bathochromic shifts (Deltalambda = 128-162 nm) upon the addition of soft metal ions (such as Hg(2+), Cr(3+), and Cu(2+)).

Synthesis of Calix[4]arenes with Four Different "Lower Rim" Substituents.

Calix[4]arenes with four different "lower rim" substituents were synthesized following six-step sequences. The first alkyl group (R(1)) was introduced using R(1)X and CH(3)ONa, and then reaction with R(2)X and K(2)CO(3) led to the introduction of a second alkyl group (R(2)) at the 3-position. Benzoate was introduced as a protecting group at the 1,3-O-disubstituent stage and was removed under basic conditions after the incorporation of the third alkyl group (R(3)) with R(3)X and NaH.