Publications by authors named "Chunluan Yuan"
Article Synopsis
- The study investigates the role of a specific gene in hepatocellular carcinoma (HCC) and its influence on cancer progression.
- By analyzing various databases, researchers found that this gene is expressed more in cancer tissues compared to non-cancerous ones and is linked to better survival rates in HCC patients when its expression is low.
- Experimental results suggest that reducing the expression of this gene can slow down cell growth and invasion in HCC by affecting several key biological pathways and promoting certain protein expressions.
Renal cell carcinoma (RCC) recurs frequently due to high metastatic spread, resulting in a high mortality. Cancer stem cells play a critical role in initiating the tumor metastasis. Inhibitor of growth 4 (ING4) is a member of the ING family, but its impact on cancer stem cells in RCC is still unknown.
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- Recent studies reveal that long noncoding RNAs (lncRNAs) are crucial in cancer cell activities like growth, death, and spread, with LINC00662 identified as a prominent lncRNA in non-small cell lung cancer (NSCLC).
- * High levels of LINC00662 correlate with worse survival rates, and its full sequence was determined through advanced genetic techniques.
- * LINC00662 promotes lung cancer growth by interacting with EZH2 to suppress the BIK gene, suggesting it could be a promising target for NSCLC treatment.
A novel MEF2C mutation in lymphoid neoplasm diffuse large B-cell lymphoma promotes tumorigenesis by increasing c-JUN expression.
Naunyn Schmiedebergs Arch Pharmacol
August 2020
Article Synopsis
- * Research identified a novel mutation in the MEF2C gene (p.N389S) linked to DLBCL, which doesn't change its expression or stability, but increases its ability to promote cell growth and tumor development.
- * The mutation boosts the expression of c-JUN, which is crucial for MEF2C's oncogenic effects, potentially leading to new treatment strategies for DLBCL.
Background: TRIM37 is an ubiquitin E3 ligase. Growing evidence has demonstrated the high value of TRIM37 as a potential biomarker for diagnosis of certain cancers. However, the biological function of TRIM37 in lung cancer is still unknown.
View Article and Find Full Text PDFBackground/aims: Increasing evidence has demonstrated a significant role of long non-coding RNAs (lncRNAs) in diverse biological processes, and many of which are likely to have functional roles in vascular remodeling. However, their functions in pulmonary arterial hypertension (PAH) remain largely unknown. Pulmonary vascular remodeling is an important pathological feature of PAH, leading to increased vascular resistance and reduced compliance.
View Article and Find Full Text PDFBackground/aims: Colorectal cancer (CRC) is the third most common type of cancer worldwide. Sprouty proteins are modulators of mitogeninduced signal transduction processes and therefore can influence the process of cancerogenesis. The encoded protein of Sprouty homolog 4 (SPRY4) is associated with various human cancers.
View Article and Find Full Text PDFThe aim of this study was to evaluate the association between thymidylate synthase (), methylenetetrahydrofolate reductase () and reduced folate carrier ( gene polymorphisms and the treatment efficacy of pemetrexed-based chemotherapy in advanced non-small cell lung cancer (NSCLC). Advanced NSCLC patients received pemetrexed and cisplatin every three weeks. Polymorphisms in the , and genes were detected in peripheral blood samples using DNA sequencing and Taqman PCR.
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