Publications by authors named "Chunlu Bu"
Objective: To predict the targets of Bufei Huoxue capsule (, BFHX) using network pharmacology analysis and to explore its effects and functional targets in a silicotic rat model.
Methods: The drug and disease targets were correlated through network pharmacology analysis to explore the targets and signaling pathways of BFHX affecting silicosis. NR8383 cells were cultured to verify the core genes and pathways.
Research progress on the pathogenesis and prediction of pneumoconiosis among coal miners.
Environ Geochem Health
July 2024
Article Synopsis
- - Pneumoconiosis, a lung disease common among coal miners, stems from long-term coal dust inhalation and can lead to severe symptoms like pulmonary fibrosis, increased pain, and higher mortality rates, with no effective treatments available.
- - The disease's pathogenesis is complex, influenced by factors such as coal dust composition, particle size, shape, and concentration, but there is currently no standardized method for early prediction among miners.
- - This review highlights recent research on pneumoconiosis in coal miners, discussing its pathogenesis and the impact of coal dust, as well as introducing diagnostic methods like image analysis and biomarker detection, and addressing challenges in early screening.