Characterization of NOD-like receptor-based molecular heterogeneity in glioma and its association with immune micro-environment and metabolism reprogramming.

Background And Purpose: The characteristics and role of NOD-like receptor (NLR) signaling pathway in high-grade gliomas were still unclear. This study aimed to reveal the association of NLR with clinical heterogeneity of glioblastoma (GBM) patients, and to explore the role of NLR pathway hub genes in the occurrence and development of GBM.

Methods: Transcriptomic data from 496 GBM patients with complete prognostic information were obtained from the TCGA, GEO, and CGGA databases.

Long noncoding RNA bridges the DREAM complex and E2f1 to regulate endoreplication in .

Rb/E2f and DREAM complexes play vital roles in regulating cell cycle progression. To date, how they coordinate their functions to regulate cell cycle-dependent gene expression is not clear. Here, we identified a long noncoding RNA (lncRNA), which we named , that bridges the interaction between E2f1 and the dREAM complex to regulate endoreplication specifically in salivary gland.

Bioinformatics analyses and experimental validation of the role of phagocytosis in low-grade glioma.

Background: Phagocytosis is of vital importance in tumor immune response. The alteration of phagocytosis in low-grade glioma (LGG) has not been investigated.

Methods: The mRNA, copy number variation, single nucleotide variation, and methylation levels of phagocytosis-related genes were summarized in pan-cancer.

Case Report and Literature Review: Pulmonary Sclerosing Pneumocytoma With Multiple Metastases Harboring E17K Somatic Mutation and C176Y Germline Mutation.

Pulmonary Sclerosing Pneumocytoma (PSP) is considered as a benign tumor, although a few cases have been reported to have multiple lesions, recurrence, and even regional lymph nodes (LNs) metastasis. Here, we report a case of PSP with atypical histologic features and malignant biological behavior, and explore its molecular genetic changes. The 23-year-old male showed a 6.

Microporous organic hydroxyl-functionalized polybenzotriazole for encouraging CO capture and separation.

We report a mild, hydroxyl functionalized and thermal stable benzotriazole-based aerogel (HO-PBTA), which is inspired by phenolic resin chemistry. Taking advantage of the synergistic adsorption interactions between hydroxy-benzotriazole and CO, and the phobic effect between benzotriazole and nitrogen (N), the CO uptake capacity of the HO-PBTA reaches an encouraging level (6.41 mmol g at 1.

Stress analysis of glenoid component in design of reverse shoulder prosthesis using finite element method.

Background: This study aims to clarify the effect of various designs of reverse shoulder prosthesis (RSP) on stress variation of its glenoid component using 2-dimensional (2D) finite element analysis (FEA). This FEA study provides future reference for the optimal design of glenoid component of RSP.

Materials And Methods: In this study, a 2D finite element (FE) model of human shoulder with implementation of RSP was developed by commercial FE software.

Color temperature tunable white light emitting diodes packaged with an omni-directional reflector.

This study proposed a correlated color temperature (CCT) tunable phosphor-converted white light emitting diode (LED) with an omni-directional reflector (ODR). Applying current to each individual InGaN based ultraviolet, purple and blue source LED chip of the white LED package, we can achieve the CCT tunability. The optimum color properties of the resulting white light are (0.

Design and fabrication of white light emitting diodes with an omnidirectional reflector.

This study investigates white light emitting diodes (LEDs), packaged with an omnidirectional reflector (ODR) and UV LED of 378 nm. The current work designs an ODR to solve the problems of UV leak and low phosphors conversion efficiency with a thin film structure of S/(HLH)n/air modified from a quarter-wave stack. Since an ODR is a perfect dielectric mirror for UV light, the UV leak can be eliminated and recycled to enhance phosphors conversion efficiency.