Notch1 siRNA and AMD3100 Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease.

: As a key mechanism of metabolic dysfunction-associated steatotic liver disease (MASLD) pathogenesis, inflammation triggered by chronic liver injury and immune cells with macrophages enables MASLD to progress to an advanced stage with irreversible processes such as fibrosis, cell necrosis, and cancer in the liver. The complexity of MASLD, including crosstalk between multiple organs and the liver, makes developing a new drug for MASLD challenging, especially in single-drug therapy. It was reported that upregulation of Notch1 is closely associated with the function of pro-inflammatory macrophages.

A broadband hyperspectral image sensor with high spatio-temporal resolution.

Hyperspectral imaging provides high-dimensional spatial-temporal-spectral information showing intrinsic matter characteristics. Here we report an on-chip computational hyperspectral imaging framework with high spatial and temporal resolution. By integrating different broadband modulation materials on the image sensor chip, the target spectral information is non-uniformly and intrinsically coupled to each pixel with high light throughput.

Emerging two-dimensional ferromagnetic semiconductors.

Two-dimensional (2D) semiconductors have attracted considerable attention for their potential in extending Moore's law and advancing next-generation electronic devices. Notably, the discovery and development of 2D ferromagnetic semiconductors (FMSs) open exciting opportunities in manipulating both charge and spin, enabling the exploration of exotic properties and the design of innovative spintronic devices. In this review, we aim to offer a comprehensive summary of emerging 2D FMSs, covering their atomic structures, physical properties, preparation methods, growth mechanisms, magnetism modulation techniques, and potential applications.

Prediction of drug-disease associations based on reinforcement symmetric metric learning and graph convolution network.

Accurately identifying novel indications for drugs is crucial in drug research and discovery. Traditional drug discovery is costly and time-consuming. Computational drug repositioning can provide an effective strategy for discovering potential drug-disease associations.

[A Family with Congenital Dysfibrinogenemia and Blood Transfusion].

Objective: To investigate a family with congenital dysfibrinogenemia, and analyze the risk of hemorrhage and thrombosis and blood transfusion strategies.

Methods: Prothrombin time (PT), activated partial thromboplastin time (APTT) and thrombin time (TT) of the proband and her family members were detected by automatic coagulometer, fibrinogen (Fg) activity and antigen were detected by Clauss method and PT algorithm respectively. Meanwhile, thromboelastometry was analyzed for proband and her family members.

Resonant-Type Piezoelectric Pump Driven by Piezoelectric Stacks and a Rhombic Micro Displacement Amplifier.

To obtain a high flow rate, a resonant-type piezoelectric pump is designed, fabricated, and studied in this paper. The pump consists of four parts: a piezoelectric vibrator, a pump chamber, a check valve and a compressible space. The designed piezoelectric vibrator is composed of a rhombic micro displacement amplifier, counterweight blocks and two piezoelectric stacks with low-voltage drive and a large output displacement.

The promoting effect of modified Dioscorea pills on vascular remodeling in chronic cerebral hypoperfusion via the Ang/Tie signaling pathway.

Objective: The objective of this study was to investigate the effect of modified Dioscorea pills (MDP) on microcirculatory remodeling in the hippocampus of rats with chronic cerebral hypoperfusion (CCH) through the angiopoietin (Ang)/tyrosine kinase receptor tyrosine kinase with immunoglobulin-like and EGF-like domains (Ang receptor) 2 (Tie-2) signaling pathways, which may underlie the cognitive improvement observed in CCH rats.

Methods: Forty male Sprague-Dawley rats raised under specific pathogen-free conditions were randomly divided into three groups: control group (10 rats), model group (15 rats), and MDP group (15 rats). The rats in the model group and MDP group underwent bilateral common carotid artery occlusion using the 2-vessel occlusion (2-VO) method to induce CCH.

Ultrahigh-security single-pixel semantic encryption.

Single-pixel encryption is a recently developed encryption technique enabling the ciphertext amount to be decreased. It adopts modulation patterns as secret keys and uses reconstruction algorithms for image recovery in the decryption process, which are time-consuming and can easily be illegally deciphered if the patterns are exposed. We report an image-free single-pixel semantic encryption technique that significantly enhances security.

Fusion-based underwater image enhancement with category-specific color correction and dehazing.

Underwater imaging is usually affected by water scattering and absorption, resulting in image blur and color distortion. In order to achieve color correction and dehazing for different underwater scenes, in this paper we report a fusion-based underwater image enhancement technique. First, statistics of the hue channel of underwater images are used to divide the underwater images into two categories: color-distorted images and non-distorted images.

Weighted sampling-adaptive single-pixel sensing.

The novel single-pixel sensing technique that uses an end-to-end neural network for joint optimization achieves high-level semantic sensing, which is effective but computation-consuming for varied sampling rates. In this Letter, we report a weighted optimization technique for sampling-adaptive single-pixel sensing, which only needs to train the network once for any dynamic sampling rate. Specifically, we innovatively introduce a weighting scheme in the encoding process to characterize different patterns' modulation efficiencies, in which the modulation patterns and their corresponding weights are updated iteratively.

Image-free multi-character recognition.

The recently developed image-free sensing technique decouples semantic information directly from compressed measurements without image reconstruction, which maintains the advantages of both the light hardware and software. However, the existing attempts have failed to classify multi-semantic information with multiple targets in the practical fieldof-view. In this Letter, we report a novel image-free sensing technique to tackle the multi-target recognition challenge for the first time, to the best of our knowledge.

Recovery preparedness of global air transport influenced by COVID-19 pandemic: Policy intervention analysis.

The outbreak of COVID-19 constitutes an unprecedented disruption globally, in which risk management framework is on top priority in many countries. Travel restriction and home/office quarantine are some frequently utilized non-pharmaceutical interventions, which bring the worst crisis of airline industry compared with other transport modes. Therefore, the post-recovery of global air transport is extremely important, which is full of uncertainty but rare to be studied.

Acute psychological impact on COVID-19 patients in Hubei: a multicenter observational study.

We conducted a multicentre cross-sectional survey of COVID-19 patients to evaluate the acute psychological impact on the patients with coronavirus disease 2019 (COVID-19) during isolation treatment based on online questionnaires from 2 February to 5 March 2020. A total of 460 COVID-19 patients from 13 medical centers in Hubei province were investigated for their mental health status using online questionnaires (including Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Patient Health Questionnaire-15, and Insomnia Severity Index scales). Among all 460 COVID-19 patients, 187 (40.

Prevalence of psychological disorders in the COVID-19 epidemic in China: A real world cross-sectional study.

Objective: This study aimed to explore the prevalence of psychological disorders and associated factors at different stages of the COVID-19 epidemic in China.

Methods: The mental health status of respondents was assessed via the Patient Health Questionnaire-9 (PHQ-9), Insomnia Severity Index (ISI) and the Generalized Anxiety Disorder 7 (GAD-7) scale.

Results: 5657 individuals participated in this study.

Protective effect of Aster tataricus extract on NLRP3-mediated pyroptosis of bladder urothelial cells.

Aster tataricus L.f. is a traditional Eastern Asian herbal medicine used for the relief of uroschesis-related illnesses and has been demonstrated clinically to exert satisfied effects.

Management of a Parkinson's disease patient with severe COVID-19 pneumonia.

Elderly populations with underlying chronic diseases are more vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and have higher mortality. Parkinson's disease (PD) is a neurodegenerative disease that occurs more often in elderly people. Currently, little is known about whether patients with PD are more susceptible to novel coronavirus disease 2019 (COVID-19) and whether the treatment of PD would affect the management of COVID-19 or vice versa.

Resilience of Alzheimer's Disease to COVID-19.

Background: Facing the novel coronavirus disease 2019 (COVID-19), most vulnerable individuals are seniors, especially those with comorbidities. More attention needs to been paid to the COVID-19 patients with Alzheimer's disease (AD), which is the top age-related neurodegenerative disease.

Objective: Since it is unclear whether AD patients are prone to COVID-19 infection and progression to severe stages, we report for the first time a retrospective analysis of the clinical characteristics of AD patients with COVID-19 pneumonia.

The evaluation of sleep disturbances for Chinese frontline medical workers under the outbreak of COVID-19.

Objective: To evaluate sleep disturbances of Chinese frontline medical workers (FMW) under the outbreak of coronavirus disease 2019 (COVID-19), and make a comparison with non-FMW.

Methods: The medical workers from multiple hospitals in Hubei Province, China, volunteered to participate in this cross-sectional study. An online questionnaire, including Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS) and Visual Analogue Scale (VAS), was used to evaluate sleep disturbances and mental status.

Synthesis, characterization, and properties of a novel aromatic ester-based polybenzoxazine.

Polybenzoxazines with molecular design flexibility have excellent properties by using suitable raw materials. A new benzoxazine monomer terephthalic acid bis-[2-(6-methyl-4-benzo[][1,3]oxazin-3-yl)]ethyl ester (TMBE) with bis-ester groups has been synthesized from the simple esterification reaction of terephthaloyl chloride and 2-(6-methyl-4-benzo[][1,3]oxazin-3-yl)-ethanol (MB-OH). The chemical structure of TMBE was characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (H-NMR, C-NMR).