Functional B cell deficiency promotes intrahepatic HBV replication and impairs the development of anti-HBV T cell responses.

Background: The pivotal role of antibody-producing B cells in controlling hepatitis B virus (HBV) infection is well-established. However, the antiviral role of B cells extends beyond antibody production, which has been insufficiently studied for HBV infection.

Methods: Using an HBV hydrodynamic injection (HDI) mouse model with B cell depletion or functional blockade, we detected HBV infection markers and assessed T cell function through enzyme-linked immunosorbent assay, RT-PCR and flow cytometry.

Copper-Driven Formation of Prothioconazole Nanocomplex: An Innovative Strategy to Prepare Nanopesticide with Improved Bioactivity and Reduced Environmental Impacts.

Developing cost-effective, energy-saving, and eco-friendly methods to construct nanopesticides fulfill the requirement of modern agriculture. Benefiting from the versatility of metal-based complexes, a facile copper-driven method is discovered for the formation of a fungicide prothioconazole nanocomplex (Cu-Pro) with the particle size of ≈300 ± 85 nm. Interestingly, adding 0.

A cluster-based incremental potential approach for reduced order homogenization of bones.

We develop a cluster-based model order reduction (called C-pRBMOR) approach for efficient homogenization of bones, compatible with a large variety of generalized standard material (GSM) models. To this end, the pRBMOR approach based on a mixed incremental potential formulation is extended to a clustered version for a significantly improved computational efficiency. The microscopic modeling of bones falls into a mixed incremental class of the GSM framework, originating from two potentials.

Effective Treatment with Venetoclax and Hypomethylating Agents for the Coexistence of Multiple Myeloma and Acute Myeloid Leukemia: A Case Report and Literature Review.

Objective: Multiple myeloma (MM) and Acute myeloid leukemia (AML) are distinct hematologic malignancies originating from different cell lineages. Their coexistence is extremely rare, and current treatment approaches are even more so. Therefore, exploring the clinical features of their coexistence and the promising treatment strategy is worthwhile.

miR-153 promotes neural differentiation by activating the cell adhesion/Ca signaling pathway and targeting ion channel activity in HT-22 cells by bioinformatic analysis.

MicroRNAs have been studied extensively in neurodegenerative diseases. In a previous study, miR-153 promoted neural differentiation and projection formation in mouse hippocampal HT-22 cells. However, the pathways and molecular mechanism underlying miR-153induced neural differentiation remain unclear.

Naked-eye rapid recognition of tyrosine enantiomers using silver triangular nanoplates as colorimetric probe.

Recognizing and quantifying enantiomers of chiral molecule is of great importance in chemical, biological and pharmaceutical fields. Herein, we presented one simple-yet-efficient method of sensing tyrosine (Tyr) enantiomers. In this sensing, silver triangular nanoplates (AgTNPs) were used as colorimetric probes.

Biodegradable electrospun fibers as sustained-release carriers of insect pheromones for field trapping of Spodoptera litura (Lepidoptera: Noctuidae).

Background: Insect pheromones are highly effective and environmentally friendly, and are widely used in the monitoring and trapping of pests. However, many researchers have found that various factors such as ultraviolet light and temperature in the field environment can accelerate the volatilization of pheromones, thus affecting the actual control effect. In recent years, electrospinning technology has demonstrated remarkable potential in the preparation of sustained carriers.

Uncovering Origin of Chirality of Gold Nanoparticles Prepared through the Conventional Citrate Reduction Method.

Chiral nanoparticles are one of the research hotspots in the field of materials science, chemistry, and biology. Understanding and controlling the chirality of nanoparticles is one key step toward their use, but the origin of nanoparticles' chirality and its determinative factor are not well understood. In this work, we studied the chirality of gold nanoparticles (AuNPs) prepared through the conventional citrate reduction method.

The Multiple Facets and Disorders of B Cell Functions in Hepatitis B Virus Infection.

Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B cells play a pivotal role in mediating HBV clearance and can participate in the development of anti-HBV adaptive immune responses through multiple mechanisms, such as antibody production, antigen presentation, and immune regulation. However, B cell phenotypic and functional disorders are frequently observed during chronic HBV infection, suggesting the necessity of targeting the disordered anti-HBV B cell responses to design and test new immune therapeutic strategies for the treatment of chronic HBV infection.

Atomic Dispersion of Zn on N-Doped Carbon Materials: From Non-Activity to High Activity for Catalyzing Luminol-HO Chemiluminescence.

Fe and Co single-atom catalysts (SACs) have been widely explored in many fields, while Zn SACs are still in their infancy stage. Herein, we unexpectedly found that atomically dispersed Zn on N-doped carbon material (Zn-N-C) exhibited high catalytic activity on luminol-HO chemiluminescence (CL) reaction. The Zn-N-C SACs were readily prepared through simple pyrolyzation of the cheap precursors (dopamine and ZnCl).

General anesthesia in children and long-term neurodevelopmental deficits: A systematic review.

Background: Millions of children experienced surgery procedures requiring general anesthesia (GA). Any potential neurodevelopmental risks of pediatric anesthesia can be a serious public health issue. Various animal studies have provided evidence that commonly used GA induced a variety of morphofunctional alterations in the developing brain of juvenile animals.

Simply prepared electrocatalyst of CoFe alloy and nitrogen-doped carbon with multi-dimensional structure and high performance for rechargeable zinc-air battery.

Simple and green preparation of highly-performed electrocatalysts for reaction both at cathode (oxygen reduction reaction (ORR)) and anode (oxygen evolution reaction (OER)) is crucial for boosting the application of meta-air battery. CoFe alloy and nitrogen doped carbon (CoFe-NC) material was prepared by a one-step carbonization procedure to construct a highly efficient electrocatalysis in this work. CoFe-NC displays a three-dimensional (3D) flower-like morphology composed of ordered stacked 2D nanosheets, which is entangled by 1D carbon nanotubes (CNTs).

Persistent Helicobacter pylori infection for more than 3 years leads to elevated serum homocysteine concentration: A retrospective cohort study based on a healthy Chinese population.

Background And Aim: The relationship between the Helicobacter pylori (H. pylori) infection and homocysteine is unclear. We evaluated the effect of H.

[Novel sternoclavicular hook-plate for treatment of proximal clavicle fracture with dislocation of sternoclavicular joint].

Objective: To explore the efficacy of a novel sternoclavicular hook-plate for treatment of proximal clavicle fracture with dislocation of sternoclavicular joint.

Methods: Retrospective analysis of 13 cases of proximal clavicle fracture with dislocation of sternoclavicular joint treated with sternoclavicular hook-plate from June 2011 to January 2019 in our department. There were 9 males and 4 females, aged 26 to 78 years old, with an average age of (54.

Metal-free N and O Co-doped carbon directly derived from bicrystal Zn-based zeolite-like metal-organic frameworks as durable high-performance pH-universal oxygen reduction reaction catalyst.

A simple and green approach is studied for the preparation of a high-activity metal-free N,O-codoped porous carbon (NOPC) electrocatalyst by one-step pyrolysis of pristine zinc-based zeolite-like metal-organic framework (Zn-ZMOF) synthesized by hydrothermal method from Znand 4,5-imidazoledicarboxylic acid (HIDC) in HO solvent. It is found that the structure and electroactivity of Zn-ZMOF and NOPC vary with the molar ratio of HIDC to zinc acetate. NOPC shows pH-universal electrocatalytic property for oxygen reduction reaction and its electrocatalytic performance is similar to that of Pt/C in alkaline and neutral electrolytes, and is close to that of Pt/C in acidic electrolyte, which is a relatively rare case for metal-free porous carbon derived from pristine MOF.

Multifunctional manganese-based carboxymethyl chitosan hydrogels for pH-triggered pesticide release and enhanced fungicidal activity.

Carboxymethyl chitosan (CMCS) has emerged as a promising biopolymer carrier for controlled release formulations of pesticide. In this study, manganese-based carboxymethyl chitosan hydrogel was facilely prepared to encapsulate and release fungicide prothioconazole in a controllable manner. The loading content (LC) and encapsulation efficiency (EE) of prothioconazole were optimized by orthogonal test.

One-step hydrothermal synthesis of chiral carbon dots with high asymmetric catalytic activity for an enantioselective direct aldol reaction.

Chiral carbon dots are prepared by a simple and one-step hydrothermal reaction at 180 °C for 2 h using citric acid and d-proline as precursors, which show high asymmetric catalytic activity for enantioselective direct aldol condensation. This work provides a hint for the simple preparation of heterogeneous chiral catalysts.

Effect of aspect ratio on the chirality of gold nanorods prepared through conventional seed-mediated growth method.

In this work, three kinds of gold nanorods (AuNRs) with different aspect ratios were synthesized through conventional seed-mediated growth method, and the chirality of these AuNRs were characterized by circular dichroism (CD) spectroscopy. The results showed that the AuNRs with bigger aspect ratio had larger chirality. The AuNRs with different aspect ratios were applied to distinguish the enantiomers of 19 kinds of α-amino acids.

Identification of miRNA-Target Gene Pairs in the Parietal and Frontal Lobes of the Brain in Patients with Alzheimer's Disease Using Bioinformatic Analyses.

Alzheimer's disease (AD) is a growing health concern worldwide. MicroRNAs (miRNAs) have been extensively studied in many diseases, including AD. To identify differentially expressed miRNAs (DEmiRNAs) and genes specific to AD, we used bioinformatic analyses to investigate candidate miRNA-mRNA pairs involved in the pathogenesis of AD.

miR-433 Inhibits Neuronal Growth and Promotes Autophagy in Mouse Hippocampal HT-22 Cell Line.

MicroRNAs (miRNAs) have an increasing functional role in some neurodegenerative diseases. Autophagy, the degradation of bulk protein in the cytoplasm, is the quality control function of protein and has a protective role in the survival of neural cells. miR-433 may play a regulatory role in neurodegenerative diseases.

Hollow and mesoporous lipstick-like nitrogen-doped carbon with incremented catalytic activity for oxygen reduction reaction.

Hollow structure and pore size are considered to be crucial to the performance of nitrogen-doped carbon materials. In this paper, a lipstick-like hollow and mesoporous nitrogen-doped carbon (HNC-1000) material is prepared using a bottom-up template participation strategy. The images by scanning electron microscopy and transmission electron microscopy show that the precursor ZnO particles, the intermediate ZnO@ZIF-8 core-shell particles, and the target HNC-1000 particles all maintain a lipstick-like morphology, and HNC-1000 is a hollow nitrogen-doped carbon material.

Polydopamine-Modified Metal-Organic Frameworks, NH-Fe-MIL-101, as pH-Sensitive Nanocarriers for Controlled Pesticide Release.

Recently, metal-organic frameworks (MOFs) have become a dazzling star among porous materials used in many fields. Considering their intriguing features, MOFs have great prospects for application in the field of sustainable agriculture, especially as versatile pesticide-delivery vehicles. However, the study of MOF-based platforms for controlled pesticide release has just begun.

Encapsulation of cuprous/cobalt sites in metal organic framework for enhanced CH/CH separation.

Adsorbents based on Cu for π-complexative separation of CH/CH have attracted widespread interests. However, they are still confronting some challenges, for example, (i) a low separation efficiency, resulted from the ineffective reduction of Cu to Cu along with aggregation, and (ii) poor stability due to the oxidation of Cu to inactive Cu. In this study, active Cu and auxiliary Co species are simultaneously encapsulated within the nanopores of MIL-101 using a double-solvent (DS) method to obtain CuCoM-DS.

Corrigendum: TLR2 Expression in Peripheral CD4+ T Cells Promotes Th17 Response and Is Associated with Disease Aggravation of Hepatitis B Virus-Related Acute-On-Chronic Liver Failure.

[This corrects the article DOI: 10.3389/fimmu.2017.

Indoxacarb-loaded fluorescent mesoporous silica nanoparticles for effective control of Plutella xylostella L. with decreased detoxification enzymes activities.

Background: Plutella xylostella L. is a cosmopolitan lepidopteron insect pest for numerous vegetables and crops. The extensive use of insecticides has resulted in the emergence of resistance in P.