Wilms' tumor gene 1 in hematological malignancies: friend or foe?

Wilms' tumor gene 1 () is a transcription and post-translational factor that has a crucial role in the biological and pathological processes of several human malignancies. For hematological malignancies, overexpression or mutation has been found in leukemia and myelodysplastic syndrome. About 70-90% of acute myeloid leukemia patients showed overexpression, and 6-15% of patients carried mutations.

Construction of three-gene-based prognostic signature and analysis of immune cells infiltration in children and young adults with B-acute lymphoblastic leukemia.

Background: Although B-acute lymphoblastic leukemia (B-ALL) patients' survival has been improved dramatically, some cases still relapse. This study aimed to explore the prognosis-related novel differentially expressed genes (DEGs) for predicting the overall survival (OS) of children and young adults (CAYAs) with B-ALL and analyze the immune-related factors contributing to poor prognosis.

Methods: GSE48558 and GSE79533 from Gene Expression Omnibus (GEO) and clinical sample information and mRNA-seq from Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database were retrieved.

A message-passing multi-task architecture for the implicit event and polarity detection.

Implicit sentiment analysis is a challenging task because the sentiment of a text is expressed in a connotative manner. To tackle this problem, we propose to use textual events as a knowledge source to enrich network representations. To consider task interactions, we present a novel lightweight joint learning paradigm that can pass task-related messages between tasks during training iterations.