Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of : Methods.

Despite the well-known health benefits of , there is a lack of understanding regarding the potential antioxidant and immunomodulatory properties of different varieties when fermented with wheat grains. We aimed to explore the potential of -fermented wheat flour as a functional food. Three varieties of (GFA, GFB, and GFC) were fermented with wheat grains for solid-state fermentation.

Heterologous expression of pediocin/papA in Bacillus subtilis.

Listeria monocytogenes is a food-borne pathogen. Pediocin is a group IIα bacteriocin with anti-listeria activity that is naturally produced by Pediococcus acidilactic and Lactobacillus plantarum. The pedA/papA gene encodes pediocin/plantaricin.

[IL-7/IL-15/IL-21/IL-23 effectively promote the generation of human CD8 central memory T cells in vitro].

Objective To compare the effect of different cytokine combinations combined with anti-CD3/CD28 beads in vitro inducing the generation of central memory T cell (Tcm). Methods Peripheral blood mononuclear cells (PBMCs) were isolated from healthy donors. Naive CD8 T cells were purified using immunomagnetic beads and stimulated with CD3/CD28 antibody for 48 hours.

An altered HLA-A0201-restricted MUC1 epitope that could induce more efficient anti-tumor effects against gastric cancer.

MUC1 is a tumor-associated antigen (TAA) overexpressed in many tumor types, which makes it an attractive target for cancer immunotherapy. However, this marker is a non-mutated antigen without high immunogenicity. In this study, we designed several new altered peptides by replacing amino acids in their sequences, which were derived from a low-affinity MUC1 peptide, thus bypassing immune tolerance.

Crystal structure of bacterial cyclopropane-fatty-acyl-phospholipid synthase with phospholipid.

The lipids containing cyclopropane-fatty-acid (CFA) protect bacteria from adverse conditions such as acidity, freeze-drying desiccation and exposure to pollutants. CFA is synthesized when cyclopropane-fatty-acyl-phospholipid synthase (CFA synthase, CFAS) transfers a methylene group from S-adenosylmethionine (SAM) across the cis double bonds of unsaturated fatty acyl chains. Here, we reported a 2.