Publications by authors named "Chunli Chen"

Purpose: Orbital inflammatory myofibroblastic tumors (IMTs) are a rare tumor with intermediate biological potential. We analyzed a series of orbital IMTs to determine their unique features.

Methods: Records from patients with pathologically confirmed IMT at Beijing Tongren Hospital, Capital Medical University, between January 2004 and August 2022, were reviewed for their ocular presentation and treatment outcomes.

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Background: This study aimed to present a case of bilateral symmetric onset of acute idiopathic maculopathy after high fever with peripheral vascular occlusion.

Case Presentation: A 54-year-old yellow female experienced acute binocular visual acuity decrease after 1 day of high fever, and binocular visual acuity decreased to index or anterior. OCT in the external hospital showed dome-shaped cortical detachment in the symmetrical macular area of both eyes with subretinal fluid, discontinuity in the ellipsoid zone and the chimera.

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. Until now, limited knowledge remains regarding the association among childhood obesity, cognitive behavior, and brain networks. Utilizing a publicly available dataset, we aimed to investigate the relationships between childhood obesity and functional networks during the stop-signal task.

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  • The study explores the knowledge, attitudes, and support required from nurses and midwives regarding perinatal mental health disorder (PMHD) screening in central China.
  • A survey conducted in Hubei province among OB/GYN professionals revealed average scores indicating modest knowledge (6.09/13), better attitudes (47.67/80), and varied support needs (29.35/35).
  • Factors such as mental health education, being a midwife, and working in specialist maternity hospitals increased knowledge scores, suggesting targeted training could enhance PMHD screening implementation.
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  • A 22-year-old woman experienced a sudden loss of vision in her right eye, diagnosed as central retinal artery occlusion (CRAO) after initially being misdiagnosed with optic neuritis.
  • She had a prior episode affecting her left eye five years earlier, which resolved on its own, and had previously experienced untreated livedo reticularis on her legs.
  • The case highlights the importance of investigating underlying systemic diseases like mixed connective tissue disease (MCTD) in young patients with CRAO to prevent future complications.
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This study aimed to investigate the current status of mental health literacy and related influencing factors in patients with coronary heart disease. Four hundred and thirty-five patients with coronary heart disease were recruited in this survey. Data collection was conducted using the General Information Questionnaire, the Chinese version of the Mental Health Literacy Scale, Coronary Artery Disease Self-Management Scale, Social Support Rating Scale, and Coronary Heart Disease Self-Efficacy Scale.

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Background: Alzheimer's disease (AD) poses a significant public health challenge, increasingly affecting patients' finances, mental health, and functional abilities as the global population ages. Stem cell-derived extracellular vesicles (SC-EVs) have emerged as a promising cell-free therapeutic approach for AD, although their precise mechanisms remain unclear. This meta-analysis aims to evaluate the effectiveness of SC-EVs in treating AD.

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  • The study investigates the differences between optic neuritis (ON) caused by the Omicron variant of SARS-CoV-2 and spontaneous demyelinating ON, focusing on clinical features and cerebrospinal fluid (CSF) characteristics.
  • Fifteen patients with Omicron-related ON and fifteen control patients with demyelinating ON were compared, revealing higher ocular pain and peripapillary hemorrhages in the Omicron group, along with elevated white cell counts in CSF.
  • The findings suggest Omicron-related ON presents with more severe symptoms and distinct CSF profiles, supporting steroid treatment while highlighting the need for tailored approaches in managing these conditions.
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  • This study investigates whether there is a causal relationship between eczema and various autoimmune diseases, using a technique called Mendelian randomization to analyze genetic data.
  • Findings reveal that genetic susceptibility to eczema is linked to an increased risk of Crohn's disease and ulcerative colitis, but not to other autoimmune diseases like systemic lupus erythematosus or multiple sclerosis.
  • The research concludes that while eczema is associated with certain autoimmune conditions, it doesn't have a causal influence on many others, and there's no evidence of autoimmune diseases causing eczema.
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Meiosis is a critical process in sexual reproduction, and errors during this cell division can significantly impact fertility. Successful meiosis relies on the coordinated action of numerous genes involved in DNA replication, strand breaks, and subsequent rejoining. DNA topoisomerase enzymes play a vital role by regulating DNA topology, alleviating tension during replication and transcription.

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20-hydroxyprogesterone (20-DHP) is a natural metabolite of progesterone which occurs with two diastereoisomers: 20α-DHP and 20β-DHP. They have drawn attention for their progesterone-like activity since the middle of the 20th century. However, the literature from that era bears witness to a lack of consensus regarding their specific effects.

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Mycoplasma gallisepticum (MG) can cause chronic respiratory disease (CRD) in chickens, which has a significant negative economic impact on the global poultry sector. Respiratory flora is the guardian of respiratory health, and its disorder is closely related to respiratory immunity and respiratory diseases. As a common probiotic in the chicken respiratory tract, Lactobacillus salivarius (L.

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Plants or tissues can be regenerated through various pathways. Like animal regeneration, cell totipotency and pluripotency are the molecular basis of plant regeneration. Detailed systematic studies on Arabidopsis thaliana gradually unravel the fundamental mechanisms and principles underlying plant regeneration.

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Introduction: Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability.

Objective: This evaluation aims to describe the pharmacokinetics of noscapine using a semi-mechanistic population pharmacokinetic model and to identify covariates that could explain inter-individual pharmacokinetic variability.

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Introduction: Intracerebral hemorrhage (ICH) often triggers oxidative stress through reactive oxygen species (ROS). Transforming growth factor-β-activated kinase 1 (TAK1) plays a pivotal role in regulating oxidative stress and inflammation across various diseases. 5Z-7-Oxozeaenol (OZ), a specific inhibitor of TAK1, has exhibited therapeutic effects in various conditions.

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Purpose: Currently, body weight-based dosing of rifampicin is recommended. But lately, fat-free mass (FFM) was reported to be superior to body weight (BW). The present evaluation aimed to assess the influence of body mass-related covariates on rifampicin's pharmacokinetics (PK) parameters in more detail using non-linear mixed effects modeling (NLMEM).

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Multiple evanescent white dot syndrome (MEWDS) is a rare fundus disease, characterized by acute vision loss and visual field defects. Many previous studies have explained the possible pathogenesis and clinical features of primary MEWDS. However, as the number of reported cases increases, secondary MEWDS occurs in other related retinal diseases and injuries, exhibiting some special characteristics.

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  • Adefovir was studied to understand how it interacts with renal transporters when combined with other drugs, showing a 20% increase in systemic exposure when used together with metformin, sitagliptin, pitavastatin, and digoxin.
  • A population pharmacokinetic (popPK) model was used to analyze data from 24 healthy subjects, revealing that adefovir's absorption and bioavailability were significantly higher during combination therapy compared to when it was administered alone.
  • The findings indicate that while co-administering drugs mainly influenced adefovir's absorption and conversion, its renal elimination process remained unchanged, suggesting limited drug-drug interactions in this context.
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The interaction between auxin and cytokinin is important in many aspects of plant development. Experimental measurements of both auxin and cytokinin concentration and reporter gene expression clearly show the coexistence of auxin and cytokinin concentration patterning in Arabidopsis root development. However, in the context of crosstalk among auxin, cytokinin, and ethylene, little is known about how auxin and cytokinin concentration patterns simultaneously emerge and how they regulate each other in the Arabidopsis root.

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Background: Non-alcoholic fatty liver disease (NAFLD), recognized as a chronic liver condition, has emerged as one of the most prevalent worldwide. This study explores the impact of artesunate (ART) on lipid accumulation and inflammatory factors within NAFLD model cells.

Methods: LO2 cells were subjected to treatment with oleic acid (OA) to establish NAFLD cell model.

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  • - Wilson disease (WD) is a genetic disorder that affects how the body processes copper, leading to various health issues, often including eye problems like Kayser-Fleischer rings and sunflower cataracts.
  • - A case study is presented about a 17-year-old girl with bilateral optic atrophy linked to WD, despite visual impairment being uncommon in WD patients.
  • - The report emphasizes that clinicians should be vigilant about the potential for optic neuropathy in patients with WD and the need for appropriate screening and recognition of this rare complication.
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Background: Bone-marrow-derived mesenchymal stromal (stem) cells [also called MSC(M)] and their extracellular vesicles (EVs) are considered a potentially innovative form of therapy for traumatic brain injury (TBI). Nevertheless, their application to TBI particularly remains preclinical, and the effects of these cells remain unclear and controversial. Therefore, an updated meta-analysis of preclinical studies is necessary to assess the effectiveness of MSC(M) and MSC(M) derived EVs in clinical trials.

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Background: Central venous catheters are widely used in clinical practice, and the incidence of central venous catheter occlusion is between 25 % and 38 %. The turbulence caused by the pulsatile flushing technique is harmful to the vascular endothelium and may lead to phlebitis. The low-speed continuous infusion catheter technique is a new type of continuous infusion that ensures that the catheter is always in a keep-vein-open state by continuous low-speed flushing; hence, avoiding the problem of catheter occlusion.

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