Ubiquitination-deficit of Cnot4 impairs the capacity of proliferation and differentiation in mouse embryonic stem cells.

Neurodevelopmental abnormalities are significant contributors to a variety of neurological disorders. Ubiquitination is essential for embryonic development and plays a pivotal role in neurodevelopment. Although Cnot4 possesses E3-ubiquitin ligase activity, its function in neurodevelopment and embryonic stem cells (ESCs) remains inadequately understood.

Dietary inflammation index is associated with dyslipidemia: evidence from national health and nutrition examination survey, 1999-2019.

Background And Aims: This study aimed to investigate the association between the Dietary Inflammatory Index (DII) and dyslipidemia, as well as to evaluate the mortality risk associated with DII in participants with dyslipidemia.

Methods: Data from the National Health and Nutrition Examination Survey database were divided into dyslipidemia and non-dyslipidemia groups. The association between DII and dyslipidemia was investigated using the weighted chi-square test, weighted t-test, and weighted logistic regression.

The association between chronic heart failure and frailty index: A study based on the National Health and Nutrition Examination Survey from 1999 to 2018.

Objective: This study aims to explore the association between the frailty index and chronic heart failure (CHF).

Methods: We collected data from the National Health and Nutrition Examination Survey (NHANES) (1998-2018) database to assess the association between CHF and frailty. Demographic, inquiry, laboratory examinations, and characteristics were gathered to compare CHF and non-CHF groups.

TCM Syndrome Recognition Model of Type 2 Diabetes Mellitus in Shanghai Based on TCM Inquiry Information.

Background: Type 2 diabetes mellitus (T2DM) has become one of the serious public health problems in China, and it affects the quality of survival of patients significantly. The long-term monitoring and early warning of T2DM and its complications should be paid attention to. Artificial diagnosis of T2DM in traditional Chinese medicine (TCM) is subjective and unrepeatable at the present stage.

Effect of serum uric acid on cognition in patients with idiopathic REM sleep behavior disorder.

Idiopathic rapid eye movement sleep behavior disorder (iRBD) likely represents the prodromal stage of synucleinopathy. The present study investigated how levels of serum uric acid (UA) affect cognition and motor function in patients with iRBD. A total of 42 patients with iRBD and 45 healthy controls were included.

The prospective memory of patients with idiopathic REM sleep behavior disorder.

Background: Idiopathic rapid eye movement sleep behavior disorder (iRBD) likely represents the prodromal stage of synucleinopathy. The present study was to investigate if there was prospective memory (PM) impairment and the relationship between different PM tasks and traditional cognitive tests in patients with iRBD.

Methods: A total of 28 patients with iRBD, 25 with Parkinson's disease (PD) and 21 healthy controls were included.

The role of the Montreal Cognitive Assessment (MoCA) and its memory tasks for detecting mild cognitive impairment.

To investigate the role of the Montreal Cognitive Assessment (MoCA) (Beijing version) and its memory tasks on detecting different mild cognitive impairment (MCI) subtypes including amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in memory clinics. A total of 121 patients with MCI and 53 healthy controls were included. Fifty-six aMCI-multiple domains (amMCI), 32 aMCI-single domain (asMCI), and 33 naMCI patients were diagnosed according to extensive cognitive tests.

Correlation of vitamin D receptor with bronchial asthma in children.

This study was designed to investigate the correlation of vitamin D receptor (VDR) gene polymorphism with bronchial asthma in children. Seventy patients admitted to Daqing Longnan Hospital and diagnosed as bronchial asthma for the first time from April 2015 to May 2017 were selected as observation group. Patients received routine treatment and intervention.

Clinical study of vitamin A combined with vitamin B in prevention and treatment of anemia in premature infants.

Background: We explored the clinical efficacy of vitamin A combined with vitamin B in the prevention and treatment of premature infants with anemia.

Methods: One hundred fifty cases of premature infants were divided into three groups. Vitamin A combined with recombinant human erythropoietin (group A), vitamin B combined with recombinant human erythropoietin (group B), vitamin A combined with vitamin B combined with recombinant human erythropoietin treatment (recorded as group C).

Transcranial sonography in idiopathic REM sleep behavior disorder and multiple system atrophy.

Aim: We investigated preclinical abnormalities as revealed by transcranial sonography (TCS) in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) compared with those revealed in patients with multiple system atrophy (MSA) or Parkinson's disease (PD) and in normal controls.

Methods: Twenty-two patients with iRBD, 21 patients with MSA, 22 patients with PD, and 21 normal controls were included in this study. All participants underwent one night of video-polysomnography monitoring, and the sleep parameters were analyzed using Polysmith software and by visual analysis.

The Gesture Imitation in Alzheimer's Disease Dementia and Amnestic Mild Cognitive Impairment.

Background: Alzheimer's disease dementia (ADD) has become an important health problem in the world. Visuospatial deficits are considered to be an early symptom besides memory disorder.

Objectives: The gesture imitation test was devised to detect ADD and amnestic mild cognitive impairment (aMCI).

Cognitive study on Chinese patients with idiopathic REM sleep behavior disorder.

Aims: We investigated cognitive abnormalities using standard tests in Chinese patients with idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) compared with those in normal controls.

Methods: Twenty-three patients with iRBD and 23 normal controls were included in this study. All of the participants underwent one night of video-polysomnography (PSG) monitoring to certify REM sleep without atonia or abnormal behaviors.