Attributes and influencing factors of hope levels in breast cancer patients: A latent profile analysis.

Purpose: This study aims to identify specific sub-types of hope levels in breast cancer (BC) patients and explore the influencing factors.

Methods: Between August and December 2023, 528 BC patients took part in this study. Latent Profile Analysis (LPA) was employed using the Herth Hope Index, Distress Thermometer, Hospital Anxiety and Depression Scale, Social Support Rating Scale, BC survivors' self-efficacy scale and Functional Assessment of Cancer Therapy-Breast to identify clusters of hope levels.

The DENSE AND ERECT PANICLE1-GRAIN NUMBER ASSOCIATED module enhances rice yield by repressing CYTOKININ OXIDASE 2 expression.

The phytohormone cytokinin (CK) positively regulates the activity of the inflorescence meristem (IM). Cytokinin oxidase 2/Grain number 1a (OsCKX2/Gn1a)-mediated degradation of CK in rice (Oryza sativa L.) negatively regulates panicle grain number, whereas DENSE AND ERECT PANICLE 1 (DEP1) positively regulates grain number per panicle (GNP).

The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study.

Background: Recent studies have indicated the role of the gut microbiota in the progression of osteoarticular diseases, however, the causal relationship between the gut microbiota and pyogenic arthritis remains unclear. There is also a lack of theoretical basis for the application of the gut microbiota in the treatment of pyogenic arthritis.

Methods: In our study, we utilized the largest genome-wide association study (GWAS) data from the MiBioGen Consortium involving 13,400 participants and extracted summary statistical data of the microbiota metabolic pathways of 7,738 participants of European descent from the Dutch Microbiome Project (DMP) The data of pyogenic arthritis were derived from the FinnGen R10 database, including 1,086 patients and 147,221 controls.

Abnormal intrinsic brain functional network dynamics in patients with retinal detachment based on graph theory and machine learning.

Background: and purpose: The investigation of functional plasticity and remodeling of the brain in patients with retinal detachment (RD) has gained increasing attention and validation. However, the precise alterations in the topological configuration of dynamic functional networks are still not fully understood. This study aimed to investigate the topological structure of dynamic brain functional networks in RD patients.

Intranasal trivalent candidate vaccine induces strong mucosal and systemic immune responses against .

The spread of multidrug-resistant strains of poses a great challenge in gonorrhea treatment. At present, vaccination is the best strategy for gonorrhea control. However, given the extensive antigenic variability of , the effectiveness of monovalent vaccines is limited.

A novel mechanism of microbial attachment: The flagellar pump of .

The ability of microbes to attach to biological and inert substrates is a necessary prerequisite for colonization of new habitats. In contrast to well-characterized mechanisms that rely on specific or nonspecific chemical interactions between microbe and substrate, we describe here an effective hydrodynamic mechanism of attachment that relies on fluid flow generated by the microbe. The microbe , a flagellated protozoan parasite, naturally attaches to the microvilliated surface of the small intestine but is also capable of attaching indiscriminately to a wide range of natural and artificial substrates.

Corrigendum: SERS-based microdroplet platform for high-throughput screening of strains for the efficient biosynthesis of D-phenyllactic acid.

[This corrects the article DOI: 10.3389/fbioe.2024.

Adjuvant osimertinib therapy guided by ctDNA-assessed MRD in resected EGFR-mutated stage IA-IIA non-small-cell lung cancer: a randomized clinical trial study protocol.

Aims: We investigate the value of postoperative minimal residual disease (MRD) detection using circulating tumor DNA (ctDNA) in guiding adjuvant therapy for patients with potentially high recurrence risk in non-small cell lung cancer (NSCLC) due to the presence of MRD.

Patients And Methods: A randomized controlled trial will enroll stage IA-IIA NSCLC patients with Epidermal Growth Factor Receptor (EGFR) mutation and negative resection margins to evaluate the clinical value of MRD in guiding adjuvant osimertinib. That is, if the patient's peripheral blood does not show ctDNA (negative) after next generation sequencing (NGS) testing, postoperative observation and follow-up are sufficient.

A unique tripartite collision tumor of the esophagus: a case report and literature review.

Background: The coexistence of two or more distinct neoplasms within the same anatomical site characterizes collision tumors. While the presence of dual tumors is frequently observed in esophageal cases, the simultaneous occurrence of three distinct tumor types is extremely rare, posing significant challenges for pathological evaluation and diagnosis. Surgical resection remains the primary treatment, with generally favorable outcomes.

Targeting the mTOR Pathway in Hepatocellular Carcinoma: The Therapeutic Potential of Natural Products.

Despite advancements in cancer treatment through surgery and drugs, hepatocellular carcinoma (HCC) remains a significant challenge, as reflected by its low survival rates. The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in regulating the cell cycle, proliferation, apoptosis, and metabolism. Notably, dysregulation leading to the activation of the mTOR signaling pathway is common in HCC, making it a key focus for in-depth research and a target for current therapeutic strategies.

The correlation between Diabetes and age-related degeneration and the static and dynamic 3D mechanical distribution of different plantar regions.

Purpose: This study aimed to compare the distribution of plantar pressure and anterior-posterior (AP) or medial-lateral (ML) shear forces in healthy younger (HY) people, healthy older (HO) people, and diabetic patients, both in static standing and during gait.

Materials And Methods: A total of 20 HY adults, 16 HO adults and 15 diabetic patients were included. The static mechanical distribution measurements included: static horizontal, AP slope plane, and left/right slope standing.

Highly efficient Ni/Ac-AlO catalysts in the dry reforming of methane: influence of acetic acid treatment and Ni loading.

The presence of abundant hydroxyl groups on the surface of AlO can promote the dispersion of Ni species but produce an inactive NiAlO phase at high temperatures. Moreover, the catalysts prepared by the conventional incipient wetness impregnation method lack the sites for the activation of CO, which leads to coke deposition and thus affects the catalyst activity. The above restricts the utilization of Ni in conventional Ni/AlO catalysts.

DNA damage-induced AIM2 pyroptosis in high glucose-induced proximal tubular epithelial cell.

Pyroptosis is one of the ways to cause proximal tubular epithelial cell death in diabetic nephropathy (DN), but the exact mechanism remains unclear. Absent in melanoma 2 (AIM2), a sensor for double-stranded DNA, creates an inflammasome that triggers the cleavage of gasdermin D (GSDMD), leading to a type of inflammatory cell death called pyroptosis. This study investigated the role of AIM2 in pyroptosis within proximal tubular epithelial cells in DN.

Effect of Vitamin D Level on Female Vaginitis in Xi'an, China.

Background: Vaginitis is a common disease of the reproductive system in women, causing discomfort in daily life. Many reports indicate that the causes of vaginitis are related to vaginal microecological disturbances. Therefore, treatment strategies to restore microecological balance have shown promising results in both basic research and clinical settings.

Association Between Female Androgen Levels, Metabolic Syndrome, and Cardiovascular Disease: An NHANES Analysis (2013-2016).

Background: The impact of androgens on metabolic diseases, cardiovascular diseases (CVD), and long-term mortality in the general female population remains poorly understood. This study, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database managed by the Centers for Disease Control and Prevention, seeks to elucidate the relationship between androgen levels and metabolic syndrome (MS), CVD, and mortality in adult women.

Methods: After excluding ineligible individuals, descriptive analyses were conducted on demographic characteristics, metabolic-related indicators, and disease prevalence, based on the presence of high androgenemia and androgen quartile grouping.

Ultrastable Seawater Oxidation at Ampere-level Current Densities with Corrosion-resistant CoCO/CoFe Layered Double Hydroxide Electrocatalyst.

Hydrogen is an essential energy resource, playing a pivotal role in advancing a sustainable future. Electrolysis of seawater shows great potential for large-scale hydrogen production but encounters challenges such as electrode corrosion caused by chlorine evolution. Herein, a durable CoCO/CoFe layered double hydroxide (LDH) electrocatalyst is presented for alkaline seawater oxidation, showcasing resistance to corrosion and stable operation exceeding 1,000 h at a high current density of 1 A cm.

Ru-O Site-Mediated Product Selectivity Switch for Overall Photocatalytic CO Reduction.

The photocatalytic reduction of carbon dioxide (CO) to methane (CH) represents a sustainable route for directly converting greenhouse gases into chemicals but poses a significant challenge in achieving high selectivity due to thermodynamic and kinetic limitations during the reaction process. This work establishes Ru-O active sites on the surface of TiO by anchoring coordination unsaturated Ru single-atoms, which stabilize crucial reaction intermediates and facilitate local mass transfer to achieve dual optimization of the thermodynamics and kinetics of the overall photocatalytic CO reduction. Combining operando spectroscopy with density functional theory (DFT) calculations indicates that oxygen vacancies (O) inhibits the desorption of *CO, whereas Ru facilitates proton extraction.

Thiol Carbazole Self-Assembled Monolayers as Tunable Carrier Injecting Interlayers for Organic Transistors and Complementary Circuits.

The significant contact resistance at the metal-semiconductor interface is a well-documented issue for organic thin-film transistors (OTFTs) that hinders device and circuit performance. Here, this issue is tackled by developing three new thiol carbazole-based self-assembled monolayer (SAM) molecules, namely tBu-2SCz, 2SCz, and Br-2SCz, and utilizing them as carrier-selective injection interlayers. The SAMs alter the work function of gold electrodes by more than 1 eV, making them suitable for use in hole and electron-transporting OTFTs.

2D Materials-Based Field-Effect Transistor Biosensors for Healthcare.

The need for accurate point-of-care (POC) tools, driven by increasing demands for precise medical diagnostics and monitoring, has accelerated the evolution of biosensor technology. Integrable 2D materials-based field-effect transistor (2D FET) biosensors offer label-free, rapid, and ultrasensitive detection, aligning perfectly with current biosensor trends. Given these advancements, this review focuses on the progress, challenges, and future prospects in the field of 2D FET biosensors.

Role of eosinophil counts in mediating the association between asthma and colon cancer.

Background: Epidemiological findings regarding the association between asthma and the risk of colon cancer (CC) are inconsistent. The causality and potential molecular mechanisms underlying asthma, eosinophil count, and CC remain unknown.

Methods: We performed Mendelian randomization (MR) analysis to investigate the causality between asthma and CC and attempted to demonstrate that asthma indirectly affects CC mediated by eosinophil count through mediation analysis.

Molecular Identification and the Hematological Findings of Four Novel Variants in Globin Genes in Jiangxi Province of Southern China.

Hemoglobin disorders are highly prevalent inherited hematological defects in Southern China. The identification of novel variants in globin genes and accurate assessment of hematological parameters play a crucial role in precise genetic counseling and clinical practice. Peripheral blood samples were collected for hematological analysis, including red blood cell and hemoglobin assessment, while serum ferritin levels were measured to detect iron depletion.

The Effects of Mindfulness on Shame: Exploring Mediation by Cognitive Flexibility and Self-Compassion in a Chinese Adult Population.

To examine the effects of mindfulness on shame and the mechanisms mediated by cognitive flexibility and self-compassion in a Chinese adult population in daily life, we conducted two studies. Study 1 was a cross-sectional study using the Five-Factor Mindfulness Questionnaire, the Cognitive Flexibility Inventory, the Self-Compassion Scale, and the Self-Conscious Affect-3, which were administered to 481 adults in Beijing and Chengdu. For Study 2, an 8-month follow-up study was conducted on 128 of the adults.

Non-Covalent Self-Assembly Behaviors Based on Racemic Binaphthol Scaffolds.

Understanding the fundamental mechanisms involved in the construction and organization of multi-scale structures is crucial for the design and manufacture of complex functional systems with long-range molecular arrangements. In this paper, a series of compounds have been synthesized using racemic binaphthols as the skeleton and a Suzuki coupling reaction for derivatization at the 6,6' positions, which resulted in various structures bearing different functional groups. Control over the self-assembly of these racemic binaphthol derivatives was successfully achieved by adjusting the types and positions of the substituents in the parent binaphthol compound, which revealed the key factors influencing the types of the non-covalent interactions and the self-assembly process.