The influence of family health on self-efficacy in patients with chronic diseases: the mediating role of perceived social support and the moderating role of health literacy.

Background: Chronic diseases are a global health challenge, and therefore, more attention should be paid to improving self-efficacy in people with chronic diseases. This study examined the relationship between family health and self-efficacy, and explored the mediating role of perceived social support and the moderating role of health literacy. The aim is to enhance the self-efficacy of chronic patients by improving family health, social support, and health literacy, thereby improving their physical and mental state.

iFlpMosaics enable the multispectral barcoding and high-throughput comparative analysis of mutant and wild-type cells.

To understand gene function, it is necessary to compare cells carrying the mutated target gene with normal cells. In most biomedical studies, the cells being compared are in different mutant and control animals and, therefore, do not experience the same epigenetic changes and tissue microenvironment. The experimental induction of genetic mosaics is essential to determine a gene cell-autonomous function and to model the etiology of diseases caused by somatic mutations.

Methionine-driven YTHDF1 expression facilitates bladder cancer progression by attenuating RIG-I-modulated immune responses and enhancing the eIF5B-PD-L1 axis.

The impact of amino acids on tumor immunotherapy is gradually being uncovered. In this study, we screened various essential and non-essential amino acids and found that methionine enhances mRNA methylation and reduced the activation of Type I interferon pathway in bladder cancer. Through RNA sequencing, point mutations, MB49 mouse tumor models, and single-cell RNA sequencing, we demonstrated that high methionine levels elevate the expression of mA reader YTHDF1, promoting the degradation of RIG-I, thereby inhibiting the RIG-I/MAVS-mediated IFN-I pathway and reducing the efficacy of tumor immunotherapy.

Eccrine poroma versus eccrine porocarcinoma: a comparative study of clinicopathological features.

Background: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm, commonly arising from its benign counterpart, eccrine poroma (EP), but potential unrevealed clinicopathological differences between them are not well understood.

Objectives: This study aimed to identify clinicopathological features of EP and EPC and describe the factors that may be associated with the malignant transformation of EP by comparing the two groups.

Methods: A total of 37 cases of EP and 22 cases of EPC diagnosed between January 2017 and June 2023 were retrospectively reviewed, and the clinical and histopathological characteristics were compared using statistical methods.

Barriers and facilitators in nurse prescribing practices: a protocol for qualitative meta-synthesis from nurses' perspectives.

Introduction: With the development of the medical system and the diversification of patient needs, nurse practitioners (NPs) play an increasingly important role in medical practice, assuming more responsibilities and powers, including the right to prescribe. However, in the process of exercising the right to prescribe, NPs may face various obstacles, and there are also some promoting factors. Therefore, this study aims to deeply explore the obstacles and promoting factors in the prescription process of NPs through a qualitative meta-analysis and comprehensive method, so as to provide a basis for improving the prescription practice of NPs, improving nursing quality and patient satisfaction.

HO-1 represses NF-κB signaling pathway to mediate microglia polarization and phagocytosis in intracerebral hemorrhage.

Background: Microglia polarization plays a crucial role in inflammatory injury of brain following intracerebral hemorrhage (ICH). Heme oxygenase-1 (HO-1) has demonstrated protective properties against inflammation and promote hematoma clearance after ICH. The objective of this study was to explore impacts of HO-1 on microglia polarization and phagocytosis after ICH, along with the underlying mechanism.

Effects of chlorogenic acid on the physicochemical properties, 3D printing characteristics, and anti-digestive properties of sweet potato starch.

This study investigated the effects of chlorogenic acid (CA) with different levels (0.5 %-2.0 %) on the printing accuracy, micro-structure, rheological properties, thermodynamic properties, texture, digestion characteristics, and other indicators of sweet potato starch (SPS).

Improvement of curcumin loading properties and bioaccessibility of beta-lactoglobulin-hyaluronic acid nanocomplexes conjugated via ultrasound-assisted Maillard reaction.

Curcumin (Cur) has many potential applications in the food industry. However, it suffers from poor water solubility, low plasma and tissue uptake and susceptibility to oxidation. In this study, β-lactoglobulin (β-LG)-hyaluronic acid (HA) binary covalent complexes were prepared by ultrasound-assisted Maillard reaction and used as the carrier to deliver Cur.

Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity.

Introduction: Ginseng demonstrates therapeutic potential in treating obesity, with both experimental and clinical studies suggesting its anti-obesity effects are mediated by gut microbiota. Nonetheless, the specific chemical components responsible for this effect remain largely unidentified.

Objectives: This study aims to investigate the anti-obesity effects and mechanisms of ginseng polysaccharides (GP) and ginsenosides (GS), the primary chemical components of ginseng, with a focus on their impact on gut microbiota.

Type I interferon-stimulated genes predict clinical response to belimumab in systemic lupus erythematosus.

The type I interferon (IFN-I) response is crucial in systemic lupus erythematosus (SLE). The mRNA level of interferon-stimulated genes (ISGs) is widely used for evaluating the activity of IFN in SLE. However, the character of ISGs in belimumab-treated SLE patients has not be reported.

Daily glucocorticoids promote glioblastoma growth and circadian synchrony to the host.

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults with a poor prognosis despite aggressive therapy. Here, we hypothesized that daily host signaling regulates tumor growth and synchronizes circadian rhythms in GBM. We find daily glucocorticoids promote or suppress GBM growth through glucocorticoid receptor (GR) signaling depending on time of day and the clock genes, Bmal1 and Cry.

Nuclear Structure of Dripline Nuclei Elucidated through Precision Mass Measurements of ^{23}Si, ^{26}P, ^{27,28}S, and ^{31}Ar.

Using the Bρ-defined isochronous mass spectrometry technique, we report the first determination of the ^{23}Si, ^{26}P, ^{27}S, and ^{31}Ar masses and improve the precision of the ^{28}S mass by a factor of 11. Our measurements confirm that these isotopes are bound and fix the location of the proton dripline in P, S, and Ar. We find that the mirror energy differences of the mirror-nuclei pairs ^{26}P-^{26}Na, ^{27}P-^{27}Mg, ^{27}S-^{27}Na, ^{28}S-^{28}Mg, and ^{31}Ar-^{31}Al deviate significantly from the values predicted assuming mirror symmetry.

Prenatal amoxicillin exposure induces depressive-like behavior in offspring via gut microbiota and myristic acid-mediated modulation of the STING pathway.

Amoxicillin is a widely used antibiotic globally, and its pervasive environmental presence poses significant risks to human health and ecosystems. Notably, prenatal amoxicillin exposure (PAmE) may have long-term neurodevelopmental toxicity for offspring. In this study, we investigated the lasting effects of PAmE on depressive-like behaviors in offspring rats, emphasizing the biological mechanisms mediated by changes in gut microbiota and its metabolite, myristic acid.

Early onset pancreatic cancer: A review.

Early-onset pancreatic cancer (EOPC) is usually defined as patients with pancreatic cancer before the age of 50 years, which is relatively rare. However, the research on EOPC is somewhat obscure, and the specific clinical and molecular characteristics of this condition are debated. In this review, we discussed the differences between EOPC and late-onset pancreatic cancer (LOPC) or average-onset pancreatic cancer (AOPC) with a focus on clinical and molecular characteristics, survival outcomes and treatment to promote the diagnosis and treatment of EOPC.

Super absorbent microsphere used for slow-release thickening.

Traditional linear polymer is commonly used for polymer flooding in tertiary oil recovery. However, it faces several problems, such as early injection allocation before use and viscosity reduction caused by high-speed shear. In this paper, a novel method of polymer flooding was proposed by using a super absorbent microsphere emulsion.

Foliar uptake, translocation and its contribution to Cadmium accumulation in rice.

Rice may absorb Cadmium (Cd) from the air through its leaves. The process of Cd foliar absorption, accumulation, and redistribution is yet unknown, nevertheless. In this study, the process of Cd absorption from rice leaves and its accumulation and redistribution during all stages of the rice plant's growth were examined.

Charge-redistributed RuNi/MoN heterojunction enables efficient hydrogen evolution in a wide pH range.

Electrocatalytic hydrogen production offers a promising solution to address current energy depletion. Herein, a RuNi/MoN heterostructure on carbon cloth (CC), RuNi/MoN@CC, was successfully constructed using a simple method, allowing for dual regulation of morphology and electronic structure. Under the influence of Ni, the in-situ generated MoN inherits the morphology of the NiMoO precursor, presenting a nanowire morphology, which is favorable for increasing electrochemical active area.

Microbes drive more carbon dioxide and nitrous oxide emissions from wetland under long-term nitrogen enrichment.

Wetlands are frequently regarded as weak carbon dioxide (CO) sinks, the largest natural sources of methane (CH), and weak sources of nitrous oxide (NO). Anthropogenic activities and climate change-induced nitrogen (N) enrichment may affect wetland carbon (C) and N cycling via soil microbes, consequently modifying the original greenhouse gas (GHG) emissions. However, the effects and mechanisms of the duration and rate of N inputs on wetland GHG emissions remain uncertain and controversial.

A longitudinal study of resilience and social function in patients with colorectal cancer and stomas.

Objective: To explore the dynamic changes, influencing factors, and relationships between resilience and social function in patients with colorectal cancer (CRC) and stomas at different postoperative stages, and to inform precise psychosocial rehabilitation interventions.

Methods: A longitudinal study was conducted at a tertiary hospital in eastern China from January 2021 to June 2023. Patients completed a self-designed socio-demographic questionnaire one month post-surgery, and the Connor and Davidson Resilience Scale (CD-RISC) and Social Dysfunction Screening Scale (SDSS) at 1, 3, and 5 months post-surgery.

Ultra-broadband bismuth-doped fiber amplifier with 170 nm bandwidth using a two-stage configuration.

We present a two-stage bismuth-doped fiber amplifier (BDFA) that achieves ultra-broadband amplification from 1280 to 1480 nm. The two-stage BDFA is designed to limit the reabsorption of bismuth-doped silica fiber (BDSF) by high-power pumps pulled fluorescence. A peak gain of 37.

Enhanced upconversion luminescence of UCNPs@CsPbI nanocomposites via constructing multiple energy transfer channels.

The application of upconversion nanomaterials relies heavily on the ability to produce bright upconversion luminescence (UCL) or high upconversion quantum yields (UCQYs) at low power density excitation. Herein, we synthesized silica-coated NaYF:Yb@NaGdF:Tm@NaYF:Tb upconversion nanoparticles (UCNPs) and CsPbI perovskites quantum dots (PeQDs) nanocomposites by the slow hydrolysis of (3-aminopropyl)triethoxysilane. The energy transfer (ET) of Gd→Tb accelerates the five-photon upconversion process of Yb-Tm and the design of the core@shell@shell layer effectively mitigates the energy jumps between Gd ions.

Hybrid SEM-ANN model for predicting undergraduates' e-learning continuance intention based on perceived educational and emotional support.

Based on the Expectation Confirmation Model (ECM), this study explores the impact of perceived educational and emotional support on university students' continuance intention to engage in e-learning. Researchers conducted a survey using structured questionnaires among 368 university students from three universities in Jiangxi Province. They measured their self-reported responses on six constructs: perceived educational support, perceived emotional support, perceived usefulness, confirmation, satisfaction, and continuance intention.

Multi-Omics Integration With Machine Learning Identified Early Diabetic Retinopathy, Diabetic Macula Edema and Anti-VEGF Treatment Response.

Purpose: Identify optimal metabolic features and pathways across diabetic retinopathy (DR) stages, develop risk models to differentiate diabetic macular edema (DME), and predict anti-vascular endothelial growth factor (anti-VEGF) therapy response.

Methods: We analyzed 108 aqueous humor samples from 78 type 2 diabetes mellitus patients and 30 healthy controls. Ultra-high-performance liquid chromatography-high-resolution-mass-spectrometry detected lipidomics and metabolomics profiles.

Primary Care-Based Digital Health-Enabled Stroke Management Intervention: Long-Term Follow-Up of a Cluster Randomized Clinical Trial.

Importance: Despite evidence of the short-term benefits of multicomponent primary care-based interventions, their long-term effects are unproven.

Objective: To evaluate the long-term outcomes of a system-integrated technology-enabled model of care (SINEMA intervention) for stroke management for systolic blood pressure (BP) and other outcomes among patients with stroke in China.

Design, Setting, And Participants: This long-term follow-up included community-dwelling clinically stable surviving participants with stroke in an open-label cluster randomized clinical trial.