An LQT2-related mutation in the voltage-sensing domain is involved in switching the gating polarity of hERG.

Background: Cyclic Nucleotide-Binding Domain (CNBD)-family channels display distinct voltage-sensing properties despite sharing sequence and structural similarity. For example, the human Ether-a-go-go Related Gene (hERG) channel and the Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) channel share high amino acid sequence similarity and identical domain structures. hERG conducts outward current and is activated by positive membrane potentials (depolarization), whereas HCN conducts inward current and is activated by negative membrane potentials (hyperpolarization).

Characterization of the role of TMEM175 in an in vitro lysosomal H fluxes model.

Lysosome acidification is a dynamic equilibrium of H influx and efflux across the membrane, which is crucial for cell physiology. The vacuolar H ATPase (V-ATPase) is responsible for the H influx or refilling of lysosomes. TMEM175 was identified as a novel H permeable channel on lysosomal membranes, and it plays a critical role in lysosome acidification.

The complete mitochondrial genome of the Leopoldamys edwardsi (Rodentia: Muridae).

The complete mitochondrial genome of L. edwardsi was first sequenced and characterized. The genome was 16,284 bases in length and the composition and arrangement of its genes are analogous to most other rodents.

Phylogenomics and evolutionary dynamics of the family Actinomycetaceae.

The family Actinomycetaceae comprises several important pathogens that impose serious threat to human health and cause substantial infections of economically important animals. However, the phylogeny and evolutionary dynamic of this family are poorly characterized. Here, we provide detailed description of the genome characteristics of Trueperella pyogenes, a prevalent opportunistic bacterium that belongs to the family Actinomycetaceae, and the results of comparative genomics analyses suggested that T.

The complete mitochondrial genome of lesser long-tailed Hamster Cricetulus longicaudatus (Milne-Edwards, 1867) and phylogenetic implications.

The complete mitochondrial genome sequence of Cricetulus longicaudatus (Rodentia Cricetidae: Cricetinae) was determined and was deposited in GenBank (GenBank accession no. KM067270). The mitochondrial genome of C.

The complete mitochondrial genome of Cricetulus kamensis (Rodentia: Cricetidae).

The Cricetulus kamensis is endemic to China and is popular as pet. In the present study, the complete mitogenome of C. kamensis was first determined.

Phylogenetic analysis of the Black Stork Ciconia nigra (Ciconiiformes: Ciconiidae) based on complete mitochondrial genome.

The Black Stork, Ciconia nigra belongs to family Ciconiidae, which is evaluated as Least Concern by IUCN. In this study, the complete mitochondrial genome of C. nigra was first sequenced and characterized, which was 17,795 bp in length.