Smart nanozymes coupled with dynamic magnet field and laser exposures for cancer therapy.

Developing nanozymes for cancer therapy has attracted great attention from researchers. However, enzymes-loaded magnetic particles triggered by both a low-frequency vibrating magnetic field (VMF) and laser for inhibiting tumor growth have never been reported. Herein, we developed a magnetic nanozyme with 3D flower-like nanostructures for cancer therapy.

Alteration in brain functional connectivity in patients with post-stroke cognitive impairment during memory task: A fNIRS study.

Objective: This study attempted to evaluate the functional connectivity (FC) in relevant cortex areas during three memory tasks using the functional near-infrared spectroscopy (fNIRS) method to expound the neural mechanisms in individuals with post-stroke cognitive impairment (PSCI).

Methods: Short-term memory and visuospatial abilities were assessed using the clock drawing test, digit span test, and Corsi Block-tapping tests with simultaneous fNIRS. The oxygenated hemoglobin concentration signals were recorded from the bilateral motor sense cortex (LMS/RMS) and prefrontal lobe (LPFT/PFT/RPFT) of 19 subjects with cognitive impairment (PSCI group), 27 stroke subjects (STR group) and 26 healthy subjects (HC group).

Low frequency vibrating magnetic field-triggered magnetic microspheres with a nanoflagellum-like surface for cancer therapy.

Background: The magneto-mechanical force killing cancer cells is an interesting and important strategy for cancer therapy.

Results: Novel magnetic microspheres composed of a FeO nanocore, a bovine serum albumin (BSA) matrix, and a rod-like SiO nanoshell, which had flagellum-like surface for force-mediated cancer therapy were developed. One such magnetic microsphere (FeO/BSA/rSiO) at a cancer cell (not leave the cell surface) under a low frequency vibrating magnetic field (VMF) could generate 6.

Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway.

Background And Objective: Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored.