Inhibition of USP1 ameliorates hypertensive nephropathy through regulating oxidative stress and ferroptosis: A precise treatment via SJB3-019A nanodelivery.

Hypertensive nephropathy is second only to diabetes for the causation of chronic kidney disease worldwide. As the mortality and morbidity of hypertensive nephropathy keep increasing, it is important to elucidate its pathogenesis and develop new treatment strategies. In this study, an angiotensin II (Ang II)-induced renal cell system was established, and the expression of ubiquitin specific peptidase 1 (USP1) in human kidney (HK-2) cells was found to be regulated by Ang II treatment through quantitative RT-PCR and Western blot assay.

Bioinformatics-based analysis of core genes and pathway enrichment in early diabetic nephropathy.

Diabetic nephropathy (DN) is the main cause of end-stage renal disease (ESRD). Bioinformatics technology was adopted to screen and analyze the core genes of early DN to explore its pathogenesis. GSE30528, GSE96804, and GSE30122 chip data were obtained from Gene Expression Omnibus (GEO) database to screen DN and healthy controls for differentially expressed genes.

Separating the Impact of Nuclear Skin and Nuclear Deformation in High-Energy Isobar Collisions.

Bulk nuclear structure properties, such as radii and deformations, leave distinct signatures in the final state of relativistic heavy-ion collisions. Isobaric collisions offer an easy route to establish explicit connections between the colliding nuclei's structure and the observable outcomes. Here, we investigate the effects of nuclear skin thickness and nuclear deformations on the elliptic flow (v_{2}) and its fluctuations in high-energy ^{96}Ru+^{96}Ru and ^{96}Zr+^{96}Zr collisions.

Metabolome and transcriptome profiling in different bagging pear fruit reveals that PbKCS10 affects the occurrence of superficial scald via regulating the wax formation.

Superficial scald is a physiological disorder of fruit, which is easy to occur during long-term cold storage after harvest. Different preharvest bagging treatments (no bagging, polyethylene bagging and non-woven fabric bagging) were used to explore the occurrence mechanism of superficial scald. UHPLC-MS analysis, GC-MS analysis and RNA-seq revealed the influence of the wax of 'Chili' on the occurrence of superficial scald.

Evidence of Quadrupole and Octupole Deformations in ^{96}Zr+^{96}Zr and ^{96}Ru+^{96}Ru Collisions at Ultrarelativistic Energies.

In the hydrodynamic model description of heavy-ion collisions, the elliptic flow v_{2} and triangular flow v_{3} are sensitive to the quadrupole deformation β_{2} and octupole deformation β_{3} of the colliding nuclei. The relations between v_{n} and β_{n} have recently been clarified and were found to follow a simple parametric form. The STAR Collaboration has just published precision v_{n} data from isobaric ^{96}Ru+^{96}Ru and ^{96}Zr+^{96}Zr collisions, where they observe large differences in central collisions v_{2,Ru}>v_{2,Zr} and v_{3,Ru} View Article and Find Full Text PDF

Impact of Nuclear Deformation on Relativistic Heavy-Ion Collisions: Assessing Consistency in Nuclear Physics across Energy Scales.

In the hydrodynamic framework of heavy-ion collisions, elliptic flow v_{2} is sensitive to the quadrupole deformation β of the colliding ions. This enables one to test whether the established knowledge on the low-energy structure of nuclei is consistent with collider data from high-energy experiments. We derive a formula based on generic scaling laws of hydrodynamics to relate the difference in v_{2} measured between collision systems that are close in size to the value of β of the respective species.

Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating .

Podocytes are epithelial cells adhering glomerular capillaries, which regulate the integrity of glomerular filtration barrier. Irreversible podocyte injury induces glomerular inflammation and causes chronic renal diseases. Kcnq1ot1, a long noncoding RNA, participates in the pathogenesis of diabetic retinopathy and cardiomyopathy.

Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling.

Protosappanin-A (PrA) and oleanolic acid (OA), which are important effective ingredients isolated from Caesalpinia sappan L., exhibit therapeutic potential in multiple diseases. This study focused on exploring the mechanisms of PrA and OA function in podocyte injury.

[Comparison of clinical effect betweem reconstructing femoral calcar and proximal femoral antirotation nail for the treatment of unstable femoral intertrochanteric fracture in elderly patients].

Objective: To compare the clinical effects of two methods of internal fixation in treating unstable femoral intertrochanteric fractures in elderly patients.

Methods: From August 2009 to August 2014, 68 elderly patients with unstable femoral intertrochanteric fracture treated with locking proximal femur plate and auxiliary short reconstructed plate (reconstructing calcar group) and proximal femoral nail antirotation (PFNA group) with clinical course from 1 to 3 days were retrospectively analyzed. In reconstructing calcar group, there were 30 patients including 8 males and 22 females, aged from 63 to 85 years old with an average of (73.