Publications by authors named "Chunji Cai"
[Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2010
Article Synopsis
- - The study aims to investigate how the NM23-H1 gene affects the invasion and metastasis of lung cancer by examining gene expression in specific lung cancer cell lines.
- - Researchers constructed a human gene expression chip and found 19 differentially expressed genes after hybridization, with 8 genes up-regulated and 2 down-regulated in the L9981 cell line transfected with the NM23-H1 gene.
- - Results suggest that NM23-H1 may act as an upstream regulator of genes associated with metastasis, influencing the metastatic potential of lung cancer.
Background: It has been proven that nm23-H1 gene is an important metastaticsuppressed gene of lung cancer. In order to screen the differential expression genes related to nm23-H1 , we constructed the suppression subtractive cDNA libraries of human large cell lung cancer line L9981 transfected and untransfected with nm23-H1 gene by suppression subtractive hybridization (SSH) in this study, which lay a solid foundation for further screening and cloning metastatic-related genes of nm23-H1.
Methods: The forward and reverse suppression subtractive cDNA libraries were constructed in the human large cell lung cancer line L9981 before and after transfection with nm23-H1 gene (L9981 and L9981-nm23-H1) by SSH method.
[Effect of 20(R) ginsenoside Rg3 on protein expression of lung cancer cell line.].
Zhongguo Fei Ai Za Zhi
June 2008
Background: Lung cancer is the most dangerous threating tumor to human's health and life. Metastasis is not only the malignant characteristics of lung cancer, but also the chief cause of failure to cure the disease and of high mortality. Ginsenoside Rg3 has been proved to have obvious effect against tumor.
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