Publications by authors named "Chunhui Tu"
Front Pharmacol
September 2024
Article Synopsis
- Osteonecrosis of the jaw (ONJ) is a serious risk associated with bisphosphonate treatment, particularly zoledronic acid, used for conditions like osteoporosis and bone metastasis, prompting the development of a predictive model for its occurrence.
- The study utilized data from the FDA Adverse Event Reporting System and the Canada Vigilance Adverse Reaction database to identify factors predicting ONJ in patients treated with zoledronic acid, applying logistic regression and nomogram analysis for model construction.
- Results revealed significant predictors for ONJ, including bone metastasis, osteoporosis, medication count, and zoledronic acid dosage, with the predictive model demonstrating strong performance in distinguishing patients at high risk of ONJ.
